Ephrin A3

EFNA3
Identifiers
Aliases	EFNA3 , EFL2, EPLG3, Ehk1-L, LERK3, ephrin A3
External IDs	OMIM: 601381 MGI: 106644 HomoloGene: 3635 GeneCards: EFNA3
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.3 Start 155,078,837 bp [1] End 155,087,538 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F1|3 39.06 cM Start 89,313,899 bp [2] End 89,322,965 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen hair follicle Region I of hippocampus proper cervix epithelium orbitofrontal cortex prefrontal cortex parotid gland nucleus accumbens Brodmann area 9 Brodmann area 46 Top expressed in lip entorhinal cortex olfactory epithelium subiculum esophagus primary motor cortex superior frontal gyrus superior colliculus skin of abdomen skin of back More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane-ephrin receptor activity protein binding ephrin receptor binding Cellular component anchored component of membrane plasma membrane integral component of plasma membrane membrane intrinsic component of plasma membrane Biological process cell-cell signaling ephrin receptor signaling pathway axon guidance negative regulation of angiogenesis regulation of neuron differentiation positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1944 13638 Ensembl ENSG00000143590 ENSMUSG00000028039 UniProt P52797 O08545 RefSeq (mRNA) NM_004952 NM_010108 RefSeq (protein) NP_004943 NP_034238 NP_001364045 NP_001364046 NP_001364047 NP_001364048 NP_001364049 NP_001364050 Location (UCSC) Chr 1: 155.08 – 155.09 Mb Chr 3: 89.31 – 89.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ephrin A3 is a protein that in humans is encoded by the EFNA3 gene. ^{[5] [6]}

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000143590 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028039 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cerretti DP, Lyman SD, Kozlosky CJ, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Kirstein MN, Shapiro DN, Morris SW (Jan 1997). "The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3". Genomics. 33 (2): 277–82. doi:10.1006/geno.1996.0192. PMID   8660976.
6. "Entrez Gene: EFNA3 ephrin-A3".

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID   9530499.
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID   9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. doi:10.1242/dev.126.10.2033. PMID   10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. International Review of Cytology. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN   978-0-12-364600-2. PMID   10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC   1692797 . PMID   11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID   11256076. S2CID   205014301.
• Kozlosky CJ, Maraskovsky E, McGrew JT, et al. (1995). "Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins". Oncogene. 10 (2): 299–306. PMID   7838529.
• Davis S, Gale NW, Aldrich TH, et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity". Science. 266 (5186): 816–9. Bibcode:1994Sci...266..816D. doi:10.1126/science.7973638. PMID   7973638.
• Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron. 17 (1): 9–19. doi: 10.1016/S0896-6273(00)80276-7 . PMID   8755474. S2CID   1075856.
• Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi: 10.1016/S0092-8674(00)80500-0 . PMID   9267020. S2CID   26773768.
• Janis LS, Cassidy RM, Kromer LF (1999). "Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum". J. Neurosci. 19 (12): 4962–71. doi: 10.1523/JNEUROSCI.19-12-04962.1999 . PMC   6782661 . PMID   10366629.
• Stein E, Savaskan NE, Ninnemann O, et al. (1999). "A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting". J. Neurosci. 19 (20): 8885–93. doi: 10.1523/JNEUROSCI.19-20-08885.1999 . PMC   6782767 . PMID   10516308.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.