KIR3DL3

KIR3DL3
Identifiers
Aliases	KIR3DL3 , CD158Z, KIR3DL7, KIR44, KIRC1, KIR2DS2, killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3
External IDs	OMIM: 610095 MGI: 3612791 HomoloGene: 77448 GeneCards: KIR3DL3
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,736,632 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	135,444,805 bp
RNA expression pattern
	Top expressed in
	blood;
	Top expressed in
	zone of skin; ; hypothalamus; ; spermatid; ; placenta;
	More reference expression data
	n/a
Orthologs
	115653
	245615
ENSG00000274394 ; ENSG00000283823 ; ENSG00000274511 ; ENSG00000276196 ; ENSG00000275433 ;
	ENSG00000276086 ; ENSG00000283875 ; ENSG00000274480 ; ENSG00000277392 ; ENSG00000274786 ; ENSG00000274724 ; ENSG00000276930 ; ENSG00000276572 ; ENSG00000284371 ; ENSG00000276084 ; ENSG00000284104 ; ENSG00000278729 ; ENSG00000277028 ; ENSG00000275062 ; ENSG00000274763 ; ENSG00000276433 ; ENSG00000274639 ; ENSG00000283966 ; ENSG00000284127 ; ENSG00000277552 ; ENSG00000278490 ; ENSG00000276806 ; ENSG00000242019 ; ENSG00000276328 ; ENSG00000276875 ; ENSG00000274556 ; ENSG00000283915 ; ENSG00000284086 ; ENSG00000278723 ; ENSG00000284480 ; ENSG00000273502 ; ENSG00000274254 ; ENSG00000275172 ; ENSG00000275513 ; ENSG00000277620 ; ENSG00000274696 ; ENSG00000277596
	ENSMUSG00000057439
	Q8N743
	Q673W2
	NM_153443
	NM_177748
	NP_703144
	NP_808416
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 04, 2024

Killer cell immunoglobulin-like receptor 3DL3 is a protein that in humans is encoded by the KIR3DL3 gene.^[5]^[6]

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.^[6]

Related Research Articles

Killer-cell immunoglobulin-like receptors (KIRs), are a family of type I transmembrane glycoproteins expressed on the plasma membrane of natural killer (NK) cells and a minority of T cells. At least 15 genes and 2 pseudogenes encoding KIR map in a 150-kb region of the leukocyte receptor complex (LRC) on human chromosome 19q13.4.

HLA-A33 (A33) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α³³ subset of HLA-A α-chains. For A33, the alpha "A" chain are encoded by the HLA-A*33 allele group and the β-chain are encoded by B2M locus. A33 and A*33 are almost synonymous in meaning. A33 is a split antigen of the broad antigen serotype A19. A33 is a sister serotype of A29, A30, A31, A32, and A74.

MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within MHC locus. MICB is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail. MICB is a stress-induced ligand for NKG2D receptor. The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.

<span class="mw-page-title-main">Major histocompatibility complex, class II, DQ alpha 1</span> Protein-coding gene in the species Homo sapiens

Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of chromosome 6 (6p21.3) and also denotes the genetic locus which contains this gene. The protein encoded by this gene is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor essential to the function of the immune system.

HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene.

Killer cell immunoglobulin-like receptor 3DL1 is a protein that in humans is encoded by the KIR3DL1 gene.

Killer cell immunoglobulin-like receptor 2DL1 is a protein that in humans is encoded by the KIR2DL1 gene.

Killer cell immunoglobulin-like receptor 2DL4 is a protein that in humans is encoded by the KIR2DL4 gene.

Leukocyte immunoglobulin-like receptor subfamily B member 4 is a protein that in humans is encoded by the LILRB4 gene.

Killer cell immunoglobulin-like receptor 3DL2 is a protein that in humans is encoded by the KIR3DL2 gene.

Corneodesmosin is a protein that in humans is encoded by the CDSN gene.

Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.

Killer cell immunoglobulin-like receptor 2DS4 is a protein that in humans is encoded by the KIR2DS4 gene.

T-cell surface glycoprotein CD1e, membrane-associated is a protein that in humans is encoded by the CD1E gene.

Butyrophilin-like protein 2 is a protein that in humans is encoded by the BTNL2 gene.

TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2.

FCGR3B, also known as CD16b, is a human gene.

Leukocyte immunoglobulin-like receptor, subfamily A, member 1 is a protein that in humans is encoded by the LILRA1 gene.

Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 is a protein that in humans is encoded by the KIR2DS1 gene.

KIR2DL3, Killer cell immunoglobulin-like receptor 2DL3 is a transmembrane glycoprotein expressed by the natural killer cells and the subsets of the T cells. The KIR genes are polymorphic, which means that they have many different alleles. The KIR genes are also extremely homologous, which means that they are similar in position, structure and evolutionary origin, but not necessarily in function.

References

1 2 3 ENSG00000283823, ENSG00000274511, ENSG00000276196, ENSG00000275433, ENSG00000276086, ENSG00000283875, ENSG00000274480, ENSG00000277392, ENSG00000274786, ENSG00000274724, ENSG00000276930, ENSG00000276572, ENSG00000284371, ENSG00000276084, ENSG00000284104, ENSG00000278729, ENSG00000277028, ENSG00000275062, ENSG00000274763, ENSG00000276433, ENSG00000274639, ENSG00000283966, ENSG00000284127, ENSG00000277552, ENSG00000278490, ENSG00000276806, ENSG00000242019, ENSG00000276328, ENSG00000276875, ENSG00000274556, ENSG00000283915, ENSG00000284086, ENSG00000278723, ENSG00000284480, ENSG00000273502, ENSG00000274254, ENSG00000275172, ENSG00000275513, ENSG00000277620, ENSG00000274696, ENSG00000277596 GRCh38: Ensembl release 89: ENSG00000274394, ENSG00000283823, ENSG00000274511, ENSG00000276196, ENSG00000275433, ENSG00000276086, ENSG00000283875, ENSG00000274480, ENSG00000277392, ENSG00000274786, ENSG00000274724, ENSG00000276930, ENSG00000276572, ENSG00000284371, ENSG00000276084, ENSG00000284104, ENSG00000278729, ENSG00000277028, ENSG00000275062, ENSG00000274763, ENSG00000276433, ENSG00000274639, ENSG00000283966, ENSG00000284127, ENSG00000277552, ENSG00000278490, ENSG00000276806, ENSG00000242019, ENSG00000276328, ENSG00000276875, ENSG00000274556, ENSG00000283915, ENSG00000284086, ENSG00000278723, ENSG00000284480, ENSG00000273502, ENSG00000274254, ENSG00000275172, ENSG00000275513, ENSG00000277620, ENSG00000274696, ENSG00000277596 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057439 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Long EO, Barber DF, Burshtyn DN, Faure M, Peterson M, Rajagopalan S, Renard V, Sandusky M, Stebbins CC, Wagtmann N, Watzl C (Aug 2001). "Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158)". Immunol Rev. 181: 223–233. doi:10.1034/j.1600-065X.2001.1810119.x. PMID 11513144. S2CID 13312691.
1 2 "Entrez Gene: KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3".

Dou LP, Zheng DH, Wang C, Liu JH, Sun JF, Jin HJ, Gao CJ, Yu L, Da WM (2008). "The diversity of KIR gene in Chinese Northern Han population and the impact of donor KIR and patient HLA genotypes on outcome following HLA-identical sibling allogeneic hematopoietic stem cell transplantation for hematological malignancy in Chinese people". Int. J. Hematol. 87 (4): 422–433. doi:10.1007/s12185-008-0058-7. PMID 18347914. S2CID 32702080.
Pavlova Y, Kolesar L, Striz I, Jabor A, Slavcev A (2008). "Distribution of KIR genes in the Czech population". International Journal of Immunogenetics. 35 (1): 57–61. doi:10.1111/j.1744-313X.2007.00737.x. PMID 18186800. S2CID 25268211.
Zhi-ming L, Yu-lian J, Zhao-lei F, Chun-Xiao W, Zhen-Fang D, Bing-Chang Z, Yue-Ran Z (2008). "Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population". Croat. Med. J. 48 (6): 800–807. doi:10.3325/cmj.2007.6.800. PMC 2213808 . PMID 18074414.
Middleton D, Meenagh A, Sleator C, Gourraud PA, Ayna T, Tozkir H, Köse AA, Azizleri G, Diler AS (2007). "No association of KIR genes with Behcet's disease". Tissue Antigens. 70 (5): 435–438. doi:10.1111/j.1399-0039.2007.00929.x. PMID 17868255.
Flores AC, Marcos CY, Paladino N, Capucchio M, Theiler G, Arruvito L, Pardo R, Habegger A, Williams F (2007). "KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations". Tissue Antigens. 69 (6): 568–576. doi:10.1111/j.1399-0039.2007.00824.x. hdl: 11336/115970 . PMID 17498266.
Chen AM, Guo XM, Yan WY, Xie SM, Zhu N, Wang XD, Xu R, Liu QP (2007). "[Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 15 (1): 35–8. PMID 17490516.
Jones DC, Hiby SE, Moffett A, Trowsdale J, Young NT (2006). "Nature of allelic sequence polymorphism at the KIR3DL3 locus". Immunogenetics. 58 (8): 614–627. doi:10.1007/s00251-006-0130-5. PMID 16823588. S2CID 6120931.
Steiner NK, Hurley CK (2006). "KIR3DL3 allelic diversity: six new alleles exhibit both conservative and non-conservative substitutions". Tissue Antigens. 67 (4): 277–283. doi:10.1111/j.1399-0039.2006.00567.x. PMID 16634863.
Zhu FM, Jiang K, Lü QF, Zhang W, Zhang HQ, Fu QH, Yan LX (2005). "[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 13 (6): 1109–12. PMID 16403292.
Trundley AE, Hiby SE, Chang C, Sharkey AM, Santourlidis S, Uhrberg M, Trowsdale J, Moffett A (2006). "Molecular characterization of KIR3DL3". Immunogenetics. 57 (12): 904–916. doi:10.1007/s00251-005-0060-7. PMID 16391939. S2CID 25125407.
Jiang K, Zhu FM, Lv QF, Yan LX (2005). "Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population". Tissue Antigens. 65 (6): 556–563. doi:10.1111/j.1399-0039.2005.00412.x. PMID 15896204.
Trompeter HI, Gómez-Lozano N, Santourlidis S, Eisermann B, Wernet P, Vilches C, Uhrberg M (2005). "Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3". J. Immunol. 174 (7): 4135–43. doi: 10.4049/jimmunol.174.7.4135 . PMID 15778373.
Arnheim L, Dillner J, Sanjeevi CB (2005). "A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia". Tissue Antigens. 65 (3): 252–259. doi:10.1111/j.1399-0039.2005.00359.x. PMID 15730517.
Norman PJ, Carrington CV, Byng M, Maxwell LD, Curran MD, Stephens HA, Chandanayingyong D, Verity DH, Hameed K (2002). "Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations". Genes Immun. 3 (2): 86–95. doi:10.1038/sj.gene.6363836. PMID 11960306. S2CID 25892926.
Torkar M, Norgate Z, Colonna M, Trowsdale J, Wilson MJ (1999). "Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex". Eur. J. Immunol. 28 (12): 3959–3967. doi: 10.1002/(SICI)1521-4141(199812)28:12<3959::AID-IMMU3959>3.0.CO;2-2 . PMID 9862332.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000283823, ENSG00000274511, ENSG00000276196, ENSG00000275433, ENSG00000276086, ENSG00000283875, ENSG00000274480, ENSG00000277392, ENSG00000274786, ENSG00000274724, ENSG00000276930, ENSG00000276572, ENSG00000284371, ENSG00000276084, ENSG00000284104, ENSG00000278729, ENSG00000277028, ENSG00000275062, ENSG00000274763, ENSG00000276433, ENSG00000274639, ENSG00000283966, ENSG00000284127, ENSG00000277552, ENSG00000278490, ENSG00000276806, ENSG00000242019, ENSG00000276328, ENSG00000276875, ENSG00000274556, ENSG00000283915, ENSG00000284086, ENSG00000278723, ENSG00000284480, ENSG00000273502, ENSG00000274254, ENSG00000275172, ENSG00000275513, ENSG00000277620, ENSG00000274696, ENSG00000277596 GRCh38: Ensembl release 89: ENSG00000274394, ENSG00000283823, ENSG00000274511, ENSG00000276196, ENSG00000275433, ENSG00000276086, ENSG00000283875, ENSG00000274480, ENSG00000277392, ENSG00000274786, ENSG00000274724, ENSG00000276930, ENSG00000276572, ENSG00000284371, ENSG00000276084, ENSG00000284104, ENSG00000278729, ENSG00000277028, ENSG00000275062, ENSG00000274763, ENSG00000276433, ENSG00000274639, ENSG00000283966, ENSG00000284127, ENSG00000277552, ENSG00000278490, ENSG00000276806, ENSG00000242019, ENSG00000276328, ENSG00000276875, ENSG00000274556, ENSG00000283915, ENSG00000284086, ENSG00000278723, ENSG00000284480, ENSG00000273502, ENSG00000274254, ENSG00000275172, ENSG00000275513, ENSG00000277620, ENSG00000274696, ENSG00000277596 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057439 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11513144-5] Long EO, Barber DF, Burshtyn DN, Faure M, Peterson M, Rajagopalan S, Renard V, Sandusky M, Stebbins CC, Wagtmann N, Watzl C (Aug 2001). "Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158)". Immunol Rev. 181: 223–233. doi:10.1034/j.1600-065X.2001.1810119.x. PMID 11513144. S2CID 13312691.

[entrez-6] 1 2 "Entrez Gene: KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3".

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[2]

[3]

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KIR3DL3

Related Research Articles

References

Further reading