LILRA5

Last updated
LILRA5
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LILRA5 , CD85, CD85F, ILT-11, ILT11, LILRB7, LIR-9, LIR9, leukocyte immunoglobulin like receptor A5
External IDs OMIM: 606047 MGI: 3647196 HomoloGene: 83297 GeneCards: LILRA5
Orthologs
SpeciesHumanMouse
Entrez

353514

232801

Ensembl

ENSMUSG00000070873

UniProt

A6NI73

D3Z7A9

RefSeq (mRNA)

NM_181986
NM_021250
NM_181879
NM_181985

NM_001081239

RefSeq (protein)

NP_067073
NP_870994
NP_871714
NP_871715

NP_001074708

Location (UCSC) Chr 19: 54.31 – 54.31 Mb Chr 7: 4.24 – 4.25 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leukocyte immunoglobulin-like receptor subfamily A member 5 (LILR-A5) also known as CD85 antigen-like family member F (CD85f), immunoglobulin-like transcript 11 (ILT-11), and leukocyte immunoglobulin-like receptor 9 (LIR-9) is a protein that in humans is encoded by the LILRA5 gene. [5] [6] [7] This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. [8] Four alternatively spliced transcript variants encoding distinct isoforms have been described.

Contents

Function

The function of LILRA5 is currently unknown. However, it is highly homologous to other LILR genes, thus it is assumed to have similar functions to other LIR family members, i.e. activating and inhibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. [9] [10]

Clinical significance

A recent genome-wide association study (GWAS) has found that genetic variations in LILRA5 are associated with late-onset sporadic Alzheimer’s disease (LOAD). [11]

LILBR2 plays a critical role in the inhibition of axonal regeneration and functional recovery after brain injury. [12] However, recent studies demonstrate that LILRB2 is a β-Amyloid receptor and may contribute to synaptic loss and cognitive impairment in Alzheimer's disease. [5] [13] Due to its proximity to LILRB2, it is believed that LILRA5 mutation may also contribute to Alzheimer's disease. [11]

Related Research Articles

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<span class="mw-page-title-main">LILRB1</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.

<span class="mw-page-title-main">APLP1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">LILRB2</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.

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Leukocyte immunoglobulin-like receptor subfamily B member 4 is a protein that in humans is encoded by the LILRB4 gene.

<span class="mw-page-title-main">LILRB3</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.

<span class="mw-page-title-main">SIGLEC9</span> Protein-coding gene in the species Homo sapiens

Sialic acid-binding Ig-like lectin 9 is a protein that in humans is encoded by the SIGLEC9 gene.

<span class="mw-page-title-main">LILRA3</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within the leukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain. The function of LILRA3 is currently unknown; however, it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.

<span class="mw-page-title-main">LILRA2</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor subfamily A member 2 is a protein that in humans is encoded by the LILRA2 gene.

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<span class="mw-page-title-main">APBB2</span> Protein-coding gene in the species Homo sapiens

Amyloid beta A4 precursor protein-binding family B member 2 is a protein that in humans is encoded by the APBB2 gene.

<span class="mw-page-title-main">TREM2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">LILRA4</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILR-A5) also known as CD85 antigen-like family member G (CD85g), and immunoglobulin-like transcript 7 (ILT-7) is a protein that in humans is encoded by the LILRA4 gene.

<span class="mw-page-title-main">LILRB5</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene.

The term "CD85" was originally used to refer to LILR1 which is now known as CD85j; however, there are a number of CD85 genes:

The leukocyte immunoglobulin-like receptors (LILR) are a family of receptors possessing extracellular immunoglobulin domains. They are also known as CD85, ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells. The human genes encoding these receptors are found in a gene cluster at chromosomal region 19q13.4.

<span class="mw-page-title-main">LILRA1</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor, subfamily A, member 1 is a protein that in humans is encoded by the LILRA1 gene.

References

  1. 1 2 3 ENSG00000274914, ENSG00000275404, ENSG00000187116, ENSG00000278355 GRCh38: Ensembl release 89: ENSG00000274113, ENSG00000274914, ENSG00000275404, ENSG00000187116, ENSG00000278355 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070873 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Lao K, Zhang R, Dai Y, Luan J, Guo N, Xu X, et al. (July 2021). "Identification of novel Aβ-LilrB2 inhibitors as potential therapeutic agents for Alzheimer's disease". Molecular and Cellular Neurosciences. 114: 103630. doi:10.1016/j.mcn.2021.103630. PMID   34029694. S2CID   235203153.
  6. ↑ "LILRA5 Gene - Leukocyte Immunoglobulin Like Receptor A5". Gene Cards. Retrieved 2021-12-11.
  7. ↑ "LILRA5 leukocyte immunoglobulin like receptor A5 [Homo sapiens (human)]". Gene - NCBI. National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2021-12-11.
  8. ↑ Torkar M, Haude A, Milne S, Beck S, Trowsdale J, Wilson MJ (December 2000). "Arrangement of the ILT gene cluster: a common null allele of the ILT6 gene results from a 6.7-kbp deletion". European Journal of Immunology. 30 (12): 3655–3662. doi:10.1002/1521-4141(200012)30:12<3655::AID-IMMU3655>3.0.CO;2-Y. PMID   11169408. S2CID   38450831.
  9. ↑ Mitchell A, Rentero C, Endoh Y, Hsu K, Gaus K, Geczy C, et al. (December 2008). "LILRA5 is expressed by synovial tissue macrophages in rheumatoid arthritis, selectively induces pro-inflammatory cytokines and IL-10 and is regulated by TNF-alpha, IL-10 and IFN-gamma". European Journal of Immunology. 38 (12): 3459–3473. doi:10.1002/eji.200838415. PMID   19009525. S2CID   34746237.
  10. ↑ Truong AD, Hong Y, Nguyen HT, Nguyen CT, Chu NT, Tran HT, et al. (February 2021). "Molecular identification and characterisation of a novel chicken leukocyte immunoglobulin-like receptor A5". British Poultry Science. 62 (1): 68–80. doi:10.1080/00071668.2020.1812524. PMID   32812773. S2CID   221180491.
  11. 1 2 Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. hdl: 1871.1/61f01aa9-6dc7-4213-be2a-d3fe622db488 . PMC   10243600 . PMID   34493870. S2CID   237442349.
  12. ↑ Mi YJ, Chen H, Guo N, Sun MY, Zhao ZH, Gao XC, et al. (2017). "Inhibition of PirB Activity by TAT-PEP Improves Mouse Motor Ability and Cognitive Behavior". Frontiers in Aging Neuroscience. 9: 199. doi: 10.3389/fnagi.2017.00199 . PMC   5476690 . PMID   28676756.
  13. ↑ Kim T, Vidal GS, Djurisic M, William CM, Birnbaum ME, Garcia KC, et al. (September 2013). "Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model". Science. 341 (6152): 1399–1404. Bibcode:2013Sci...341.1399K. doi:10.1126/science.1242077. PMC   3853120 . PMID   24052308.
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