LILRA4

LILRA4
Identifiers
Aliases	LILRA4 , CD85g, ILT7, leukocyte immunoglobulin like receptor A4
External IDs	OMIM: 607517 HomoloGene: 69118 GeneCards: LILRA4
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,339,162 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; monocyte; ; blood; ; appendix; ; substantia nigra; ; gallbladder; ; bone marrow cells; ; prefrontal cortex; ; smooth muscle tissue;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; signaling receptor binding ; coreceptor activity ;
Cellular component	membrane ; integral component of membrane ; integral component of plasma membrane ; Fc-epsilon receptor I complex ; plasma membrane ;
Biological process	immune system process ; negative regulation of interferon-alpha production ; negative regulation of tumor necrosis factor production ; negative regulation of toll-like receptor 7 signaling pathway ; negative regulation of toll-like receptor 9 signaling pathway ; Fc-epsilon receptor signaling pathway ; innate immune response ;
	Sources:Amigo / QuickGO
Orthologs
	23547
	n/a
	ENSG00000277092 ; ENSG00000276798 ; ENSG00000274185 ; ENSG00000239961
	n/a
	P59901
	n/a
	NM_012276
	n/a
	NP_036408
	n/a
	Wikidata
View/Edit Human

Last updated September 30, 2022

Leukocyte immunoglobulin-like receptor subfamily A member 4 is a protein that in humans is encoded by the LILRA4 gene.^[3]^[4]

This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte immunoglobulin-like receptor gene cluster (LRC) at chromosomal region 19q13.4.^[4]

Related Research Articles

Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.

Killer cell immunoglobulin-like receptor 3DL1 is a protein that in humans is encoded by the KIR3DL1 gene.

Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene. LAIR1 has also been designated as CD305.

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.

Leukocyte immunoglobulin-like receptor subfamily B member 4 is a protein that in humans is encoded by the LILRB4 gene.

Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene. NCR1 has also been designated as CD335 (cluster of differentiation, NKP46, NKp46, NK-p46, and LY94.

Leukocyte-specific transcript 1 protein is a protein that in humans is encoded by the LST1 gene.

Fc receptor-like protein 5 is a protein that in humans is encoded by the FCRL5 gene. FCRL5 has also been designated as CD307.

Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.

Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within the leukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain. The function of LILRA3 is currently unknown; however, it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.

Leukocyte immunoglobulin-like receptor subfamily A member 2 is a protein that in humans is encoded by the LILRA2 gene.

Osteoclast-associated immunoglobulin-like receptor is a protein that in humans is encoded by the OSCAR gene.

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.

Fc receptor-like protein 4 is a protein that in humans is encoded by the FCRL4 gene. FCRL4 is an inhibitory receptor expressed on human memory B cells which resides in epithelial tissues.

Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene.

Fc receptor-like protein 1 is a protein that in humans is encoded by the FCRL1 gene.

Killer cell immunoglobulin-like receptor 3DL3 is a protein that in humans is encoded by the KIR3DL3 gene.

The leukocyte immunoglobulin-like receptors (LILR) are a family of receptors possessing extracellular immunoglobulin domains. They are also known as CD85, ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells. The human genes encoding these receptors are found in a gene cluster at chromosomal region 19q13.4.

Leukocyte immunoglobulin-like receptor, subfamily A, member 1 is a protein that in humans is encoded by the LILRA1 gene.

Leukocyte immunoglobulin-like receptor subfamily A member 5 (LILR-A5) also known as CD85 antigen-like family member F (CD85f), immunoglobulin-like transcript 7 (ILT-7), and leukocyte immunoglobulin-like receptor 9 (LIR-9) is a protein that in humans is encoded by the LILRA5 gene. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described.

References

1 2 3 ENSG00000276798, ENSG00000274185, ENSG00000239961 GRCh38: Ensembl release 89: ENSG00000277092, ENSG00000276798, ENSG00000274185, ENSG00000239961 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
1 2 "Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4".

Cho M, Ishida K, Chen J, et al. (2008). "SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production". Int. Immunol. 20 (1): 155–64. doi: 10.1093/intimm/dxm127 . PMID 18048391.
Sellick GS, Wade R, Richards S, et al. (2008). "Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis". Blood. 111 (3): 1625–33. doi: 10.1182/blood-2007-08-110130 . PMID 18006695.
Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
Cao W, Rosen DB, Ito T, et al. (2006). "Plasmacytoid dendritic cell–specific receptor ILT7–FcɛRIγ inhibits Toll-like receptor–induced interferon production". J. Exp. Med. 203 (6): 1399–405. doi:10.1084/jem.20052454. PMC 2118323 . PMID 16735691.
Ju XS, Hacker C, Scherer B, et al. (2004). "Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation". Gene. 331: 159–64. doi:10.1016/j.gene.2004.02.018. PMID 15094202.
Tedla N, Bandeira-Melo C, Tassinari P, et al. (2003). "Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1174–9. Bibcode:2003PNAS..100.1174T. doi: 10.1073/pnas.0337567100 . PMC 298746 . PMID 12529506.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Rissoan MC, Duhen T, Bridon JM, et al. (2002). "Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells". Blood. 100 (9): 3295–303. doi: 10.1182/blood-2002-02-0638 . PMID 12384430.
Young NT, Canavez F, Uhrberg M, et al. (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–8. doi:10.1007/s002510100332. PMID 11491530. S2CID 2819935.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000276798, ENSG00000274185, ENSG00000239961 GRCh38: Ensembl release 89: ENSG00000277092, ENSG00000276798, ENSG00000274185, ENSG00000239961 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10941842-3] Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.

[entrez-4] 1 2 "Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4".

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LILRA4

Related Research Articles

References

Further reading