Mechanoreceptor

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A mechanoreceptor, also called mechanoceptor, is a sensory receptor that responds to mechanical pressure or distortion. Mechanoreceptors are located on sensory neurons that convert mechanical pressure into electrical signals that, in animals, are sent to the central nervous system.

Contents

Vertebrate mechanoreceptors

Cutaneous mechanoreceptors

Cutaneous mechanoreceptors respond to mechanical stimuli that result from physical interaction, including pressure and vibration. They are located in the skin, like other cutaneous receptors. They are all innervated by Aβ fibers, except the mechanorecepting free nerve endings, which are innervated by Aδ fibers. Cutaneous mechanoreceptors can be categorized by what kind of sensation they perceive, by the rate of adaptation, and by morphology. Furthermore, each has a different receptive field.[ citation needed ]

Tactile receptors. Blausen 0809 Skin TactileReceptors.png
Tactile receptors.

By sensation

  • The Slowly Adapting type 1 (SA1) mechanoreceptor, with the Merkel corpuscle end-organ (also known as Merkel discs) detect sustained pressure and underlies the perception of form and roughness on the skin. [1] They have small receptive fields and produce sustained responses to static stimulation.[ citation needed ]
  • The Slowly Adapting type 2 (SA2) mechanoreceptors, with the Ruffini corpuscle end-organ (also known as the bulbous corpuscles), detect tension deep in the skin and fascia and respond to skin stretch, but have not been closely linked to either proprioceptive or mechanoreceptive roles in perception. [2] They also produce sustained responses to static stimulation, but have large receptive fields.[ citation needed ]
  • The Rapidly Adapting (RA) or Meissner corpuscle end-organ mechanoreceptor (also known as the tactile corpuscles) underlies the perception of light touch such as flutter [3] and slip on the skin. [4] It adapts rapidly to changes in texture (vibrations around 50 Hz). They have small receptive fields and produce transient responses to the onset and offset of stimulation.[ citation needed ]
  • The Pacinian corpuscle or Vater-Pacinian corpuscles or Lamellar corpuscles [5] in the skin and fascia detect rapid vibrations of about 200–300 Hz. [3] [6] They also produce transient responses, but have large receptive fields.
  • Free nerve endings detect touch, pressure, stretching, as well as the tickle and itch sensations. Itch sensations are caused by stimulation of free nerve ending from chemicals. [7]
  • Hair follicle receptors called hair root plexuses sense when a hair changes position. Indeed, the most sensitive mechanoreceptors in humans are the hair cells in the cochlea of the inner ear (no relation to the follicular receptors – they are named for the hair-like mechanosensory stereocilia they possess); these receptors transduce sound for the brain. [7]

By rate of adaptation

Cutaneous mechanoreceptors can also be separated into categories based on their rates of adaptation. When a mechanoreceptor receives a stimulus, it begins to fire impulses or action potentials at an elevated frequency (the stronger the stimulus, the higher the frequency). The cell, however, will soon "adapt" to a constant or static stimulus, and the pulses will subside to a normal rate. Receptors that adapt quickly (i.e., quickly return to a normal pulse rate) are referred to as "phasic". Those receptors that are slow to return to their normal firing rate are called tonic. Phasic mechanoreceptors are useful in sensing such things as texture or vibrations, whereas tonic receptors are useful for temperature and proprioception among others.[ citation needed ]

By receptive field

Cutaneous mechanoreceptors with small, accurate receptive fields are found in areas needing accurate taction (e.g. the fingertips). In the fingertips and lips, innervation density of slowly adapting type I and rapidly adapting type I mechanoreceptors are greatly increased. These two types of mechanoreceptors have small discrete receptive fields and are thought to underlie most low-threshold use of the fingers in assessing texture, surface slip, and flutter. Mechanoreceptors found in areas of the body with less tactile acuity tend to have larger receptive fields.[ citation needed ]

Lamellar corpuscles

Lamellar corpuscles, or Pacinian corpuscles or Vater-Pacini corpuscle, are deformation or pressure receptors located in the skin and also in various internal organs. [8] Each is connected to a sensory neuron. Because of its relatively large size, a single lamellar corpuscle can be isolated and its properties studied. Mechanical pressure of varying strength and frequency can be applied to the corpuscle by stylus, and the resulting electrical activity detected by electrodes attached to the preparation.[ citation needed ]

Deforming the corpuscle creates a generator potential in the sensory neuron arising within it. This is a graded response: the greater the deformation, the greater the generator potential. If the generator potential reaches threshold, a volley of action potentials (nerve impulses) are triggered at the first node of Ranvier of the sensory neuron.[ citation needed ]

Once threshold is reached, the magnitude of the stimulus is encoded in the frequency of impulses generated in the neuron. So the more massive or rapid the deformation of a single corpuscle, the higher the frequency of nerve impulses generated in its neuron.[ citation needed ]

The optimal sensitivity of a lamellar corpuscle is 250 Hz, the frequency range generated upon finger tips by textures made of features smaller than 200  micrometres. [9]

Ligamentous mechanoreceptors

There are four types of mechanoreceptors embedded in ligaments. As all these types of mechanoreceptors are myelinated, they can rapidly transmit sensory information regarding joint positions to the central nervous system. [10]

Type II and Type III mechanoreceptors in particular are believed to be linked to one's sense of proprioception.

Other mechanoreceptors

Other mechanoreceptors than cutaneous ones include the hair cells, which are sensory receptors in the vestibular system of the inner ear, where they contribute to the auditory system and equilibrioception. Baroreceptors are a type of mechanoreceptor sensory neuron that is excited by stretch of the blood vessel. There are also juxtacapillary (J) receptors, which respond to events such as pulmonary edema, pulmonary emboli, pneumonia, and barotrauma.[ citation needed ]

Muscle spindles and the stretch reflex

The knee jerk is the popularly known stretch reflex (involuntary kick of the lower leg) induced by tapping the knee with a rubber-headed hammer. The hammer strikes a tendon that inserts an extensor muscle in the front of the thigh into the lower leg. Tapping the tendon stretches the thigh muscle, which activates stretch receptors within the muscle called muscle spindles. Each muscle spindle consists of sensory nerve endings wrapped around special muscle fibers called intrafusal muscle fibers. Stretching an intrafusal fiber initiates a volley of impulses in the sensory neuron (a I-a neuron) attached to it. The impulses travel along the sensory axon to the spinal cord where they form several kinds of synapses:[ citation needed ]

  1. Some of the branches of the I-a axons synapse directly with alpha motor neurons. These carry impulses back to the same muscle causing it to contract. The leg straightens.
  2. Some of the branches of the I-a axons synapse with inhibitory interneurons in the spinal cord. These, in turn, synapse with motor neurons leading back to the antagonistic muscle, a flexor in the back of the thigh. By inhibiting the flexor, these interneurons aid contraction of the extensor.
  3. Still other branches of the I-a axons synapse with interneurons leading to brain centers, e.g., the cerebellum, that coordinate body movements. [11]

Mechanism of sensation

In somatosensory transduction, the afferent neurons transmit messages through synapses in the dorsal column nuclei, where second-order neurons send the signal to the thalamus and synapse with third-order neurons in the ventrobasal complex. The third-order neurons then send the signal to the somatosensory cortex.[ citation needed ]

More recent work has expanded the role of the cutaneous mechanoreceptors for feedback in fine motor control. [12] Single action potentials from Meissner's corpuscle, Pacinian corpuscle and Ruffini ending afferents are directly linked to muscle activation, whereas Merkel cell-neurite complex activation does not trigger muscle activity. [13]

Invertebrate mechanoreceptors

Insect and arthropod mechanoreceptors include: [14]

Plant mechanoreceptors

Mechanoreceptors are also present in plant cells where they play an important role in normal growth, development and the sensing of their environment. [20] Mechanoreceptors aid the Venus flytrap (Dionaea muscipula Ellis) in capturing large [21] prey. [22]

Molecular biology

Mechanoreceptor proteins are ion channels whose ion flow is induced by touch. Early research showed that touch transduction in the nematode Caenorhabditis elegans was found to require a two transmembrane, amiloride-sensitive ion channel protein related to epithelial sodium channels (ENaCs). [23] This protein, called MEC-4, forms a heteromeric Na+-selective channel together with MEC-10. Related genes in mammals are expressed in sensory neurons and were shown to be gated by low pH. The first of such receptor was ASIC1a, named so because it is an acid sensing ion channel (ASIC). [24]

See also

Related Research Articles

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In neuroanatomy, the trigeminal nerve (lit. triplet nerve), also known as the fifth cranial nerve, cranial nerve V, or simply CN V, is a cranial nerve responsible for sensation in the face and motor functions such as biting and chewing; it is the most complex of the cranial nerves. Its name (trigeminal, from Latin tri- 'three' and -geminus 'twin') derives from each of the two nerves (one on each side of the pons) having three major branches: the ophthalmic nerve (V1), the maxillary nerve (V2), and the mandibular nerve (V3). The ophthalmic and maxillary nerves are purely sensory, whereas the mandibular nerve supplies motor as well as sensory (or "cutaneous") functions. Adding to the complexity of this nerve is that autonomic nerve fibers as well as special sensory fibers (taste) are contained within it.

<span class="mw-page-title-main">Sensory nervous system</span> Part of the nervous system

The sensory nervous system is a part of the nervous system responsible for processing sensory information. A sensory system consists of sensory neurons, neural pathways, and parts of the brain involved in sensory perception and interoception. Commonly recognized sensory systems are those for vision, hearing, touch, taste, smell, balance and visceral sensation. Sense organs are transducers that convert data from the outer physical world to the realm of the mind where people interpret the information, creating their perception of the world around them.

<span class="mw-page-title-main">Stimulus (physiology)</span> Detectable change in the internal or external surroundings

In physiology, a stimulus is a change in a living thing's internal or external environment. This change can be detected by an organism or organ using sensitivity, and leads to a physiological reaction. Sensory receptors can receive stimuli from outside the body, as in touch receptors found in the skin or light receptors in the eye, as well as from inside the body, as in chemoreceptors and mechanoreceptors. When a stimulus is detected by a sensory receptor, it can elicit a reflex via stimulus transduction. An internal stimulus is often the first component of a homeostatic control system. External stimuli are capable of producing systemic responses throughout the body, as in the fight-or-flight response. In order for a stimulus to be detected with high probability, its level of strength must exceed the absolute threshold; if a signal does reach threshold, the information is transmitted to the central nervous system (CNS), where it is integrated and a decision on how to react is made. Although stimuli commonly cause the body to respond, it is the CNS that finally determines whether a signal causes a reaction or not.

<span class="mw-page-title-main">Free nerve ending</span> Type of nerve fiber carrying sensory signals

A free nerve ending (FNE) or bare nerve ending, is an unspecialized, afferent nerve fiber sending its signal to a sensory neuron. Afferent in this case means bringing information from the body's periphery toward the brain. They function as cutaneous nociceptors and are essentially used by vertebrates to detect noxious stimuli that often result in pain.

Stimulus modality, also called sensory modality, is one aspect of a stimulus or what is perceived after a stimulus. For example, the temperature modality is registered after heat or cold stimulate a receptor. Some sensory modalities include: light, sound, temperature, taste, pressure, and smell. The type and location of the sensory receptor activated by the stimulus plays the primary role in coding the sensation. All sensory modalities work together to heighten stimuli sensation when necessary.

A cutaneous receptor is a sensory receptor found in the skin that provides information about temperature, touch, spatial orientation,pressure, and metabolic circumstances. The main four types of cutaneous receptors are tactile corpuscles, bulbous corpuscles, Pacinian corpuscles, and Merkel nerve endings, although the latter do not qualify as sensory corpuscles in the narrow sense.

<span class="mw-page-title-main">Tactile corpuscle</span> Type of mechanoreceptor that detects light touch

Tactile corpuscles or Meissner's corpuscles are a type of mechanoreceptor discovered by anatomist Georg Meissner (1829–1905) and Rudolf Wagner. This corpuscle is a type of nerve ending in the skin that is responsible for sensitivity to pressure. In particular, they have their highest sensitivity when sensing vibrations between 10 and 50 hertz. They are rapidly adaptive receptors. They are most concentrated in thick hairless skin, especially at the finger pads.

<span class="mw-page-title-main">Sensory neuron</span> Nerve cell that converts environmental stimuli into corresponding internal stimuli

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<span class="mw-page-title-main">Pacinian corpuscle</span> Type of mechanoreceptor cell in hairless mammals

The Pacinian corpuscle is a low-threshold mechanoreceptor responsive to vibration or pressure, found in the skin and other internal organs. In the skin it is one of the four main types of cutaneous receptors.

Merkel nerve endings are mechanoreceptors situated in the basal epidermis as well as around the apical ends or some hair follicles. They are slowly adapting. They have small receptive fields measuring some milimeters in diameter. Most are associated with fast-conducting large myelinated axons. A single afferent nerve fibre branches to innervate up to 90 such endings. Merkel nerve endings respond to light touch. They respond to sustained pressure, and are sensitive to edges of objects. Their exact functions remain controversial.

<span class="mw-page-title-main">Tactile corpuscles of Grandry</span>

The tactile corpuscles of Grandry or Grandry corpuscles are mechanoreceptors found in the beak skin and oral mucosa of aquatic birds including waterfowl. They were first described in 1869 in the bill skin of ducks and geese. Their general structure includes the flattened endings of an afferent nerve fiber sandwiched between two or more somewhat flattened sensory cells called Grandry cells, all surrounded by a layer of satellite cells and a partial capsule of collagen protein. Electrophysiological studies have shown that Grandry corpuscles function as rapidly adapting velocity detectors. In birds, Grandry and Merkel corpuscles share many morphological similarities, which has led to some confusion in the literature over their classification.

<span class="mw-page-title-main">Microneurography</span> Medical diagnostic method

Microneurography is a neurophysiological method employed to visualize and record the traffic of nerve impulses that are conducted in peripheral nerves of waking human subjects. It can also be used in animal recordings. The method has been successfully employed to reveal functional properties of a number of neural systems, e.g. sensory systems related to touch, pain, and muscle sense as well as sympathetic activity controlling the constriction state of blood vessels. To study nerve impulses of an identified nerve, a fine tungsten needle microelectrode is inserted into the nerve and connected to a high input impedance differential amplifier. The exact position of the electrode tip within the nerve is then adjusted in minute steps until the electrode discriminates nerve impulses of interest. A unique feature and a significant strength of the microneurography method is that subjects are fully awake and able to cooperate in tests requiring mental attention, while impulses in a representative nerve fibre or set of nerve fibres are recorded, e.g. when cutaneous sense organs are stimulated or subjects perform voluntary precision movements.

Cutaneous innervation refers to an area of the skin which is supplied by a specific cutaneous nerve.

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Pallesthesia, or vibratory sensation, is the ability to perceive vibration. This sensation, often conducted through skin and bone, is usually generated by mechanoreceptors such as Pacinian corpuscles, Merkel disk receptors, and tactile corpuscles. All of these receptors stimulate an action potential in afferent nerves found in various layers of the skin and body. The afferent neuron travels to the spinal column and then to the brain where the information is processed. Damage to the peripheral nervous system or central nervous system can result in a decline or loss of pallesthesia.

<span class="mw-page-title-main">Axon reflex</span>

The axon reflex is the response stimulated by peripheral nerves of the body that travels away from the nerve cell body and branches to stimulate target organs. Reflexes are single reactions that respond to a stimulus making up the building blocks of the overall signaling in the body's nervous system. Neurons are the excitable cells that process and transmit these reflex signals through their axons, dendrites, and cell bodies. Axons directly facilitate intercellular communication projecting from the neuronal cell body to other neurons, local muscle tissue, glands and arterioles. In the axon reflex, signaling starts in the middle of the axon at the stimulation site and transmits signals directly to the effector organ skipping both an integration center and a chemical synapse present in the spinal cord reflex. The impulse is limited to a single bifurcated axon, or a neuron whose axon branches into two divisions and does not cause a general response to surrounding tissue.

<span class="mw-page-title-main">Somatosensory system</span> Nerve system for sensing touch, temperature, body position, and pain

The somatosensory system, or somatic sensory system is a subset of the sensory nervous system. It has two subdivisions, one for the detection of mechanosensory information related to touch, and the other for the nociception detection of pain and temperature. The main functions of the somatosensory system are the perception of external stimuli, the perception of internal stimuli, and the regulation of body position and balance (proprioception).

Group A nerve fibers are one of the three classes of nerve fiber as generally classified by Erlanger and Gasser. The other two classes are the group B nerve fibers, and the group C nerve fibers. Group A are heavily myelinated, group B are moderately myelinated, and group C are unmyelinated.

References

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