Transduction (physiology)

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Principal steps of sensory processing. SensoryProcessing.png
Principal steps of sensory processing.

In physiology, transduction is the translation of arriving stimulus into an action potential by a sensory receptor. It begins when stimulus changes the membrane potential of a receptor cell.

Contents

A receptor cell converts the energy in a stimulus into an electrical signal. [1] Receptors are broadly split into two main categories: exteroceptors, which receive external sensory stimuli, and interoceptors, which receive internal sensory stimuli. [2] [3]

Transduction and the senses

The visual system

In the visual system, sensory cells called rod and cone cells in the retina convert the physical energy of light signals into electrical impulses that travel to the brain. The light causes a conformational change in a protein called rhodopsin. [1] This conformational change sets in motion a series of molecular events that result in a reduction of the electrochemical gradient of the photoreceptor. [1] The decrease in the electrochemical gradient causes a reduction in the electrical signals going to the brain. Thus, in this example, more light hitting the photoreceptor results in the transduction of a signal into fewer electrical impulses, effectively communicating that stimulus to the brain. A change in neurotransmitter release is mediated through a second messenger system. The change in neurotransmitter release is by rods. Because of the change, a change in light intensity causes the response of the rods to be much slower than expected (for a process associated with the nervous system). [4]

The auditory system

In the auditory system, sound vibrations (mechanical energy) are transduced into electrical energy by hair cells in the inner ear. Sound vibrations from an object cause vibrations in air molecules, which in turn, vibrate the ear drum. The movement of the eardrum causes the bones of the middle ear (the ossicles) to vibrate. [5] [6] These vibrations then pass into the cochlea, the organ of hearing. Within the cochlea, the hair cells on the sensory epithelium of the organ of Corti bend and cause movement of the basilar membrane. The membrane undulates in different sized waves according to the frequency of the sound. Hair cells are then able to convert this movement (mechanical energy) into electrical signals (graded receptor potentials) which travel along auditory nerves to hearing centres in the brain. [7]

The olfactory system

In the olfactory system, odorant molecules in the mucus bind to G-protein receptors on olfactory cells. The G-protein activates a downstream signalling cascade that causes increased level of cyclic-AMP (cAMP), which trigger neurotransmitter release. [8]

The gustatory system

In the gustatory system, perception of five primary taste qualities (sweet, salty, sour, bitter and umami [savoriness] ) depends on taste transduction pathways, through taste receptor cells, G proteins, ion channels, and effector enzymes. [9]

The somatosensory system

In the somatosensory system the sensory transduction mainly involves the conversion of the mechanical signal such as pressure, skin compression, stretch, vibration to electro-ionic impulses through the process of mechanotransduction. [10] It also includes the sensory transduction related to thermoception and nociception.

Related Research Articles

<span class="mw-page-title-main">Cochlea</span> Snail-shaped part of inner ear involved in hearing

The cochlea is the part of the inner ear involved in hearing. It is a spiral-shaped cavity in the bony labyrinth, in humans making 2.75 turns around its axis, the modiolus. A core component of the cochlea is the Organ of Corti, the sensory organ of hearing, which is distributed along the partition separating the fluid chambers in the coiled tapered tube of the cochlea.

<span class="mw-page-title-main">Sensory nervous system</span> Part of the nervous system responsible for processing sensory information

The sensory nervous system is a part of the nervous system responsible for processing sensory information. A sensory system consists of sensory neurons, neural pathways, and parts of the brain involved in sensory perception and interoception. Commonly recognized sensory systems are those for vision, hearing, touch, taste, smell, balance and visceral sensation. Sense organs are transducers that convert data from the outer physical world to the realm of the mind where people interpret the information, creating their perception of the world around them.

<span class="mw-page-title-main">Photoreceptor cell</span> Type of neuroepithelial cell

A photoreceptor cell is a specialized type of neuroepithelial cell found in the retina that is capable of visual phototransduction. The great biological importance of photoreceptors is that they convert light into signals that can stimulate biological processes. To be more specific, photoreceptor proteins in the cell absorb photons, triggering a change in the cell's membrane potential.

<span class="mw-page-title-main">Stimulation</span> Providing something that rouses the recipient to activity

Stimulation is the encouragement of development or the cause of activity generally. For example, "The press provides stimulation of political discourse." An interesting or fun activity can be described as "stimulating", regardless of its physical effects on senses. Stimulate means to act as a stimulus to; stimulus means something that rouses the recipient to activity; stimuli is the plural of stimulus.

A receptor potential, also known as a generator potential, a type of graded potential, is the transmembrane potential difference produced by activation of a sensory receptor.

<span class="mw-page-title-main">Organ of Corti</span> Receptor organ for hearing

The organ of Corti, or spiral organ, is the receptor organ for hearing and is located in the mammalian cochlea. This highly varied strip of epithelial cells allows for transduction of auditory signals into nerve impulses' action potential. Transduction occurs through vibrations of structures in the inner ear causing displacement of cochlear fluid and movement of hair cells at the organ of Corti to produce electrochemical signals.

<span class="mw-page-title-main">Stimulus (physiology)</span> Detectable change in the internal or external surroundings

In physiology, a stimulus is a detectable change in the physical or chemical structure of an organism's internal or external environment. The ability of an organism or organ to detect external stimuli, so that an appropriate reaction can be made, is called sensitivity (excitability). Sensory receptors can receive information from outside the body, as in touch receptors found in the skin or light receptors in the eye, as well as from inside the body, as in chemoreceptors and mechanoreceptors. When a stimulus is detected by a sensory receptor, it can elicit a reflex via stimulus transduction. An internal stimulus is often the first component of a homeostatic control system. External stimuli are capable of producing systemic responses throughout the body, as in the fight-or-flight response. In order for a stimulus to be detected with high probability, its level of strength must exceed the absolute threshold; if a signal does reach threshold, the information is transmitted to the central nervous system (CNS), where it is integrated and a decision on how to react is made. Although stimuli commonly cause the body to respond, it is the CNS that finally determines whether a signal causes a reaction or not.

The adequate stimulus is a property of a sensory receptor that determines the type of energy to which a sensory receptor responds with the initiation of sensory transduction. Sensory receptor are specialized to respond to certain types of stimuli. The adequate stimulus is the amount and type of energy required to stimulate a specific sensory organ.

Stimulus modality, also called sensory modality, is one aspect of a stimulus or what is perceived after a stimulus. For example, the temperature modality is registered after heat or cold stimulate a receptor. Some sensory modalities include: light, sound, temperature, taste, pressure, and smell. The type and location of the sensory receptor activated by the stimulus plays the primary role in coding the sensation. All sensory modalities work together to heighten stimuli sensation when necessary.

A mechanoreceptor, also called mechanoceptor, is a sensory receptor that responds to mechanical pressure or distortion. Mechanoreceptors are innervated by sensory neurons that convert mechanical pressure into electrical signals that, in animals, are sent to the central nervous system.

<span class="mw-page-title-main">Auditory system</span> Sensory system used for hearing

The auditory system is the sensory system for the sense of hearing. It includes both the sensory organs and the auditory parts of the sensory system.

<span class="mw-page-title-main">Sensory neuron</span> Nerve cell that converts environmental stimuli into corresponding internal stimuli

Sensory neurons, also known as afferent neurons, are neurons in the nervous system, that convert a specific type of stimulus, via their receptors, into action potentials or graded potentials. This process is called sensory transduction. The cell bodies of the sensory neurons are located in the dorsal ganglia of the spinal cord.

<span class="mw-page-title-main">Hair cell</span> Auditory sensory receptor nerve cells

Hair cells are the sensory receptors of both the auditory system and the vestibular system in the ears of all vertebrates, and in the lateral line organ of fishes. Through mechanotransduction, hair cells detect movement in their environment.

<span class="mw-page-title-main">Stereocilia (inner ear)</span>

In the inner ear, stereocilia are the mechanosensing organelles of hair cells, which respond to fluid motion in numerous types of animals for various functions, including hearing and balance. They are about 10–50 micrometers in length and share some similar features of microvilli. The hair cells turn the fluid pressure and other mechanical stimuli into electric stimuli via the many microvilli that make up stereocilia rods. Stereocilia exist in the auditory and vestibular systems.

<span class="mw-page-title-main">Mechanotransduction</span> Conversion of mechanical stimulus of a cell into electrochemical activity

In cellular biology, mechanotransduction is any of various mechanisms by which cells convert mechanical stimulus into electrochemical activity. This form of sensory transduction is responsible for a number of senses and physiological processes in the body, including proprioception, touch, balance, and hearing. The basic mechanism of mechanotransduction involves converting mechanical signals into electrical or chemical signals.

In medicine and anatomy, the special senses are the senses that have specialized organs devoted to them:

A topographic map is the ordered projection of a sensory surface, like the retina or the skin, or an effector system, like the musculature, to one or more structures of the central nervous system. Topographic maps can be found in all sensory systems and in many motor systems.

A sense is a biological system used by an organism for sensation, the process of gathering information about the world through the detection of stimuli. Although traditionally five human senses were identified as such, it is now recognized that there are many more. Senses used by non-human organisms are even greater in variety and number. During sensation, sense organs collect various stimuli for transduction, meaning transformation into a form that can be understood by the brain. Sensation and perception are fundamental to nearly every aspect of an organism's cognition, behavior and thought.

The neural encoding of sound is the representation of auditory sensation and perception in the nervous system. The complexities of contemporary neuroscience are continually redefined. Thus what is known of the auditory system has been continually changing. The encoding of sounds includes the transduction of sound waves into electrical impulses along auditory nerve fibers, and further processing in the brain.

Electrocochleography is a technique of recording electrical potentials generated in the inner ear and auditory nerve in response to sound stimulation, using an electrode placed in the ear canal or tympanic membrane. The test is performed by an otologist or audiologist with specialized training, and is used for detection of elevated inner ear pressure or for the testing and monitoring of inner ear and auditory nerve function during surgery.

References

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