Tactile hallucination

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Formication, a type of tactile hallucination, is the feeling of imaginary insects or spiders on the skin. Tactile hallucination.jpg
Formication, a type of tactile hallucination, is the feeling of imaginary insects or spiders on the skin.

Tactile hallucination is the false perception of tactile sensory input that creates a hallucinatory sensation of physical contact with an imaginary object. [1] It is caused by the faulty integration of the tactile sensory neural signals generated in the spinal cord and the thalamus and sent to the primary somatosensory cortex (SI) and secondary somatosensory cortex (SII). [2] Tactile hallucinations are recurrent symptoms of neurological diseases such as schizophrenia, Parkinson's disease, Ekbom's syndrome and delirium tremens. Patients who experience phantom limb pains also experience a type of tactile hallucination. Tactile hallucinations are also caused by drugs such as cocaine and alcohol. [1]

Contents

History and background

During ancient Greek times, touch was considered to be an unrefined perceptual system because it differed from the other senses on the basis of the distance and timing of perception of the stimulus. Unlike vision and audition, one perceives touch simultaneously with the medium and the stimulus is always proximal and not distal. [1]

By the 17th century, the British empiricist John Locke attributed the word "feeling" with two types of sensation. [1] Weber distinctly identified these two types of sensation as the sense of touch and common bodily sensibility. [1] This distinction further helped 19th century psychiatrists to distinguish between tactile hallucinations and cenesthopathy.

During the 19th century, tactile hallucinations were classified as symptoms associated with insanity, organic and toxic syndromes and delusional parasitosis yet there was no identification on how such hallucinations were caused. [1] Neuroscientists such as Dr. Oliver Sacks and Dr. V.S. Ramachandran have analyzed and attributed tactile hallucinations as a dysfunctional perception of the brain as opposed to just a symptom related to insanity. They have contributed significantly to propose tactile hallucinations as the false perception of tactile sensory input creating a sensation of touch with an imaginary object.

In schizophrenia

Hallucinations of pain and touch are very rare in schizophrenic disorders but 20% of patients with schizophrenia experience some sort of tactile hallucinations along with visual and auditory hallucinations. [3] The most common tactile hallucination in patients with schizophrenia is a sensation in which a patch of their skin is stretched elastically across their head. [4] They vary in intensity, range and speed at which they feel this stretching painful sensation. They are usually triggered by emotional cues such as guilt, anger, fear and depression. [4] Other types of tactile hallucinations takes on a sexual form in patients with schizophrenia. Patients with schizophrenia may sometimes experience the feeling of being kissed or the feeling of someone lying by their side in response to their emotion of being lonely. [1] Additionally, they occasionally hallucinate the feeling of small animals such as snakes crawling over their body. [1] Such vivid tactile sensation of an object that is not present results from the unsuccessful attempt of the brain trying to perceive objects that are novel and that represent unreal situations usually triggered by guilt and fear. [4] Patients with schizophrenia also have a hard time portraying emotions as they divert most of their energy to control the pain from their tactile hallucinations. [4]

Olfactory and tactile hallucinations correlate with one another in terms of prevalence in patients with schizophrenia. [3] One particular study was conducted by Langdon et al., in which the prevalence of olfactory hallucinations and tactile hallucinations was analyzed in two distinct clinical samples of patients with schizophrenia. One of the samples contained patients with schizophrenia with tactile hallucinations as reported by the World Health Organization while the other sample contained cases with negative and positive types of tactile hallucinations in patients with schizophrenia. It was concluded that about 13% to 17% of patients with schizophrenia experience olfactory and tactile hallucinations. [5] The study reported that socio-cultural factors influenced self-reporting of tactile hallucinations. Since hallucinations in general were feared as a symptoms of insanity, patients were reluctant to seek help for such symptoms. [5] Moreover, the study concluded that tactile hallucinations were usually accompanied by several other hallucinations associated with different modalities such as taste and sight. [5] However, the study failed to recognize the pathophysiology of tactile hallucinations in individuals with schizophrenia.

In Parkinson's disease

Trihexyphenidyl: An antiparkinsonian agent that creates tactile hallucinations. Trihexyphenidyl.svg
Trihexyphenidyl: An antiparkinsonian agent that creates tactile hallucinations.

About 7% of individuals with Parkinson's disease (PD) also experience mild or severe types of tactile hallucinations. [6] Most of these hallucinations are based on the sensation of a particular kind of animal. [6] Several case studies were conducted by Fénelon and his colleagues on patients with PD that had tactile hallucinations. One of his patients described that he sensed "spiders and cockroaches chewing on his lower limb" which was rather painful. [6] Several other patients felt that there was a parasitic infestation of their skin which caused lesions on their skins due to the obsessive need of itching. [6] Fénelon also analyzed the particular types of tactile hallucinations experienced, the timing of such experience and certain drugs that could eliminate such experience. It was concluded that patients with both PD and tactile hallucinations not only experienced sensations elicited by insects under their skin but also by vivid tactile sensations of people. [6] These hallucinations were aggravated during evening times due to altered arousal states and were alleviated by dopaminergic treatment such as the intake of clozapine. [6] The study also explains that the pathophysiology of tactile hallucinations is uncertain, however, such hallucinations can be attributed to narcoleptic rapid eye movement sleep disorders due to its concordance with visual hallucinations. [6] Moreover, it emphasizes that individuals who have had PD for a longer period of time have a more severe form of tactile hallucinations than with individuals who have succumbed to this disease for just a short period of time. [6]

Clinical drugs used as an antiparkinsonian agent such as Trihexyphenidyl are known to create tactile hallucinations in patients with PD. [7] [8]

Restless legs syndrome

Hallucinatory itch due to sensation of insects under the skin leading to self-hurting behavior. Itch 02.jpg
Hallucinatory itch due to sensation of insects under the skin leading to self-hurting behavior.

Restless legs syndrome (RLS) causes unpleasant or uncomfortable sensations in the legs and an irresistible urge to move them. [9] [10] Tactile hallucinations in RLS include feelings of itching, pulling, crawling or creeping mainly in the legs, with the accompanying overwhelming urge to move them. [9] [10] These symptoms are more prominent in the late afternoon and at night, often causing insomnia. [9] The causes of RLS are generally unknown, though there are three major hypotheses: iron deficiency, dopamine insufficiency and genetic inheritance. [9] [10] RLS can also occur due to nerve damage, or neuropathy. [9] Treatments for RLS typically focus on symptom relief through supplementing iron, blocking nerve receptors through the use of alpha-2 delta drugs such as gabapentin, or through the use of opioids or benzodiazepines. [10]

Phantom limbs

Treatments for phantom limb pains: Virtually Painless- Science Museum Painless Exhibition Series.

Phantom limb pain is a type of tactile hallucination because it creates a sensation of excruciating pain in a limb that has been amputated. [11] In 1996, VS Ramachandran conducted a research on several amputees to pinpoint the neural reasons behind these illusionary pains. Most of these amputees that had an unbearable phantom limb pain are reported by patients whose limb was paralyzed before amputation. VS Ramachandran proposed the "learned paralysis" hypothesis. The hypothesis suggested that every time the patients tried to move their paralyzed limb, they received sensory feedback (through vision and proprioception) that the limb did not move. This feedback hardwired itself into the brain circuitry, so that, even when the limb was no longer present, the brain had learned that the phantom limb was paralyzed. [11] As a treatment for phantom limb pains, VS Ramachandran devised a mirror box that would superimpose the mirror image of the normal arm in place of the missing arm and the patient would immediately be relieved of the pain. This suggested that the brain had a plastic nature in the somatosensory system and the brain had reorganized its somatosensory region to accommodate for this new change. [11] Patients that experience this phantom limb pain are very important in research studies for their role in determining brain plasticity. The vivid tactile sensation of the arm that is no longer present suggest the highly complex nature of the brain to reorganize different functions which were once thought to be hardwired to specific regions (localization).

Inducement through drugs

Organic and toxic syndromes can also induce tactile hallucinations. The use of cocaine for recreational purposes has been reported to induce tactile hallucinations. [12] They usually have sensations of moving itches and crawling insects. Cocaine and alcohol can induce rapid firing of neuronal cells of the somatosensory region of the brain leading to vivid perception of illusionary bugs on the skin. [12] Additionally, as mentioned above, Trihexyphenidyl is an antiparkinsonian drug that creates tactile hallucination. The mechanism through which these drugs induce tactile hallucinations is still unknown.

Cenesthopathy

Cenesthopathy is a rare medical term used to refer to the feeling of being ill and this feeling is not localized to one region of the body. [1] Cenesthopathic hallucinatory experiences are caused by the hyperactive neuronal stimulation of the primary somatosensory cortex due to a disorder or a damage to this area. There are two theories that are established to portray sensation of unified bodily feeling. One of these theories is called associationism, which states that cenesthesia is an amalgamation of propioceptive and interoceptive sensations. [1] Faculty psychology is the other theory which states that there is a particular brain region where all of the sensory information converged and the integration of this information gives one cenesthetic sensation. The latter theory became more predominant and it established two types of cenestopathic hallucinations namely "painful" and "paraesthetic". Patients that experience "painful" type of cenesthopathic hallucination felt that their organs were stretched apart and twisted. [1] On the other hand, patients with "paraesthetic" cenesthopathic hallucination experience severe hallucinatory itching. [1]

Pathophysiology

Schematic and FMRI of cortical areas involved in pain processing which are similar to areas that are involved in tactile hallucinations. Schematic of cortical areas involved with pain processing and fMRI.jpg
Schematic and FMRI of cortical areas involved in pain processing which are similar to areas that are involved in tactile hallucinations.

Tactile hallucinations are the result of a dysfunctional somatosensory and a dysfunctional awareness regions of the brain. [2] Tactile sensory input is produced and conducted through the spinal cord and thalamus and it is received at the primary somatosensory cortex. Once it has reached the primary somatosensory cortex, it is distributed across the brain and it will not be processed unless it is important and one pays close attention to the information based on a specific context. Consciousness to these specific tactile sensations is generated only through multiple feedback loops passing through higher cortical areas such as secondary somatosensory area, parietal, insular cortex and premotor areas. [2] The intensity of the tactile stimulus is directly proportional to the area of the primary somatosensory region activated. [13] A feedback mechanism from different cortical areas results in the awareness of touch. Even with complete sensory deprivation, discrete tactile memories can trigger spontaneous firing of impaired neurons. [2] Therefore, individuals with various psychiatric disorders are more prone to tactile hallucinations than normal individuals.

Tactile hallucinations are especially possible due to faulty sensory integration of neuronal signals in the primary and secondary somatosensory system with neuronal signals in the parietal cortex, insular cortex and premotor cortex. Moreover, the posterior insula is responsible for mental body schema representation and can produce tactile hallucination if defected. Additionally, the regions of the brain involved in tactile hallucinations are similar to the regions of the brain involved in pain.

See also

Related Research Articles

<span class="mw-page-title-main">Hallucination</span> Perception in the absence of external stimulation that has the qualities of real perception

A hallucination is a perception in the absence of an external stimulus that has the qualities of a real perception. Hallucinations are vivid, substantial, and are perceived to be located in external objective space. Hallucination is a combination of two conscious states of brain wakefulness and REM sleep. They are distinguishable from several related phenomena, such as dreaming, which does not involve wakefulness; pseudohallucination, which does not mimic real perception, and is accurately perceived as unreal; illusion, which involves distorted or misinterpreted real perception; and mental imagery, which does not mimic real perception, and is under voluntary control. Hallucinations also differ from "delusional perceptions", in which a correctly sensed and interpreted stimulus is given some additional significance.

<span class="mw-page-title-main">Phantom limb</span> Sensation that an amputated or missing limb is attached

A phantom limb is the sensation that an amputated or missing limb is still attached. It is a chronic condition which often resistant to treat. when the cut ends of sensory fibres are stimulated during thigh movements, the patient feels as if the sensation is arising from the non-existent limb. Sometimes the patient might feel pain in the non-existent limb. Approximately 80–100% of individuals with an amputation experience sensations in their amputated limb. However, only a small percentage will experience painful phantom limb sensation. These sensations are relatively common in amputees and usually resolve within two to three years without treatment. Research continues to explore the underlying mechanisms of phantom limb pain (PLP) and effective treatment options.

<span class="mw-page-title-main">Sensory nervous system</span> Part of the nervous system

The sensory nervous system is a part of the nervous system responsible for processing sensory information. A sensory system consists of sensory neurons, neural pathways, and parts of the brain involved in sensory perception and interoception. Commonly recognized sensory systems are those for vision, hearing, touch, taste, smell, balance and visceral sensation. Sense organs are transducers that convert data from the outer physical world to the realm of the mind where people interpret the information, creating their perception of the world around them.

<span class="mw-page-title-main">V. S. Ramachandran</span> Indian-American neuroscientist

Vilayanur Subramanian Ramachandran is an Indian-American neuroscientist. He is known for his wide-ranging experiments and theories in behavioral neurology, including the invention of the mirror box. Ramachandran is a distinguished professor in UCSD's Department of Psychology, where he is the director of the Center for Brain and Cognition.

<span class="mw-page-title-main">Temporal lobe</span> One of the four lobes of the mammalian brain

The temporal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The temporal lobe is located beneath the lateral fissure on both cerebral hemispheres of the mammalian brain.

<span class="mw-page-title-main">Sensory neuron</span> Nerve cell that converts environmental stimuli into corresponding internal stimuli

Sensory neurons, also known as afferent neurons, are neurons in the nervous system, that convert a specific type of stimulus, via their receptors, into action potentials or graded receptor potentials. This process is called sensory transduction. The cell bodies of the sensory neurons are located in the dorsal ganglia of the spinal cord.

Phantom pain is a painful perception that an individual experiences relating to a limb or an organ that is not physically part of the body, either because it was removed or was never there in the first place.

<span class="mw-page-title-main">Aura (symptom)</span> Symptom of epilepsy and migraine

An aura is a perceptual disturbance experienced by some with epilepsy or migraine. An epileptic aura is a seizure.

<span class="mw-page-title-main">Phantom eye syndrome</span> Medical condition

The phantom eye syndrome (PES) is a phantom pain in the eye and visual hallucinations after the removal of an eye.

Dysesthesia is an unpleasant, abnormal sense of touch. Its etymology comes from the Greek word "dys," meaning "bad," and "aesthesis," which means "sensation". It often presents as pain but may also present as an inappropriate, but not discomforting, sensation. It is caused by lesions of the nervous system, peripheral or central, and it involves sensations, whether spontaneous or evoked, such as burning, wetness, itching, electric shock, and pins and needles. Dysesthesia can include sensations in any bodily tissue, including most often the mouth, scalp, skin, or legs.

Tactile discrimination is the ability to differentiate information through the sense of touch. The somatosensory system is the nervous system pathway that is responsible for this essential survival ability used in adaptation. There are various types of tactile discrimination. One of the most well known and most researched is two-point discrimination, the ability to differentiate between two different tactile stimuli which are relatively close together. Other types of discrimination like graphesthesia and spatial discrimination also exist but are not as extensively researched. Tactile discrimination is something that can be stronger or weaker in different people and two major conditions, chronic pain and blindness, can affect it greatly. Blindness increases tactile discrimination abilities which is extremely helpful for tasks like reading braille. In contrast, chronic pain conditions, like arthritis, decrease a person's tactile discrimination. One other major application of tactile discrimination is in new prosthetics and robotics which attempt to mimic the abilities of the human hand. In this case tactile sensors function similarly to mechanoreceptors in a human hand to differentiate tactile stimuli.

Dejerine–Roussy syndrome or thalamic pain syndrome is a condition developed after a thalamic stroke, a stroke causing damage to the thalamus. Ischemic strokes and hemorrhagic strokes can cause lesioning in the thalamus. As initial stroke symptoms dissipate, an imbalance in sensation causes these later syndromes, characterizing Dejerine–Roussy syndrome. Although some treatments exist, they are often expensive, chemically based, invasive, and only treat patients for some time before they need more treatment, called "refractory treatment".

<span class="mw-page-title-main">Somatosensory system</span> Nerve system for sensing touch, temperature, body position, and pain

Touch is perceiving the environment using skin. Specialized receptors in the skin send signals to the brain indicating light and soft pressure, hot and cold, body position and pain. It is a subset of the sensory nervous system, which also includes the visual, auditory, olfactory, gustatory and vestibular senses.

A somatosensory disorder is an impairment of the somatosensory system.

Extinction is a neurological disorder that impairs the ability to perceive multiple stimuli of the same type simultaneously. Extinction is usually caused by damage resulting in lesions on one side of the brain. Those who are affected by extinction have a lack of awareness in the contralesional side of space and a loss of exploratory search and other actions normally directed toward that side.

Amorphosynthesis, also called a hemi-sensory deficit, is a neuropsychological condition in which a patient experiences unilateral inattention to sensory input. This phenomenon is frequently associated with damage to the right cerebral hemisphere resulting in severe sensory deficits that are observed on the contralesional (left) side of the body. A right-sided deficit is less commonly observed and the effects are reported to be temporary and minor. Evidence suggests that the right cerebral hemisphere has a dominant role in attention and awareness to somatic sensations through ipsilateral and contralateral stimulation. In contrast, the left cerebral hemisphere is activated only by contralateral stimuli. Thus, the left and right cerebral hemispheres exhibit redundant processing to the right-side of the body and a lesion to the left cerebral hemisphere can be compensated by the ipsiversive processes of the right cerebral hemisphere. For this reason, right-sided amorphosynthesis is less often observed and is generally associated with bilateral lesions.

Many types of sense loss occur due to a dysfunctional sensation process, whether it be ineffective receptors, nerve damage, or cerebral impairment. Unlike agnosia, these impairments are due to damages prior to the perception process.

Mirror-touch synesthesia is a rare condition which causes individuals to experience a similar sensation in the same part or opposite part of the body that another person feels. For example, if someone with this condition were to observe someone touching their cheek, they would feel the same sensation on their own cheek. Synesthesia, in general, is described as a condition in which a concept or sensation causes an individual to experience an additional sensation or concept. Synesthesia is usually a developmental condition; however, recent research has shown that mirror touch synesthesia can be acquired after sensory loss following amputation.

<span class="mw-page-title-main">Cortical remapping</span>

Cortical remapping, also referred to as cortical reorganization, is the process by which an existing cortical map is affected by a stimulus resulting in the creating of a 'new' cortical map. Every part of the body is connected to a corresponding area in the brain which creates a cortical map. When something happens to disrupt the cortical maps such as an amputation or a change in neuronal characteristics, the map is no longer relevant. The part of the brain that is in charge of the amputated limb or neuronal change will be dominated by adjacent cortical regions that are still receiving input, thus creating a remapped area. Remapping can occur in the sensory or motor system. The mechanism for each system may be quite different. Cortical remapping in the somatosensory system happens when there has been a decrease in sensory input to the brain due to deafferentation or amputation, as well as a sensory input increase to an area of the brain. Motor system remapping receives more limited feedback that can be difficult to interpret.

Dyschiria, also known as dyschiric syndrome, is a neurological disorder where one-half of an individual's body or space cannot be recognized or respond to sensations. The term dyschiria is rarely used in modern scientific research and literature. Dyschiria has been often referred to as unilateral neglect, visuo-spatial neglect, or hemispatial neglect from the 20th century onwards. Psychologists formerly characterized dyschiric patients to be unable to discriminate or report external stimuli. This left the patients incapable of orienting sensory responses in their extrapersonal and personal space. Patients with dyschiria are unable to distinguish one side of their body in general, or specific segments of the body. There are three stages to dyschiria: achiria, allochiria, and synchiria, in which manifestations of dyschiria evolve in varying degrees.

References

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