IBC 293

IBC 293

Identifiers
IUPAC name 1-propan-2-ylbenzotriazole-5-carboxylic acid
CAS Number	306935-41-1
PubChem CID	2736690
IUPHAR/BPS	1597
ChemSpider	2018348
ChEBI	CHEBI:92275
ChEMBL	ChEMBL381638
CompTox Dashboard (EPA)	DTXSID70371532
Chemical and physical data
Formula	C10H11N3O2
Molar mass	205.217 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)N1C2=C(C=C(C=C2)C(=O)O)N=N1
InChI InChI=1S/C10H11N3O2/c1-6(2)13-9-4-3-7(10(14)15)5-8(9)11-12-13/h3-6H,1-2H3,(H,14,15) Key:RUTVRAJKELSHCC-UHFFFAOYSA-N

IBC 293 is an experimental drug which acts as a potent and selective agonist for the Hydroxycarboxylic acid receptor 3 (GPR109B), with good selectivity over the closely related HCA2/GPR109A receptor. It is used for studying the function of this receptor, and has been shown to activate neutrophils, demonstrating a role for HCA3 in immune system function. ^{[1] [2] [3]}

References

1. Semple G, Skinner PJ, Cherrier MC, Webb PJ, Sage CR, Tamura SY, et al. (February 2006). "1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b". Journal of Medicinal Chemistry. 49 (4): 1227–1230. doi:10.1021/jm051099t. PMID   16480258.
2. Boatman PD, Richman JG, Semple G (December 2008). "Nicotinic acid receptor agonists". Journal of Medicinal Chemistry. 51 (24): 7653–7662. doi:10.1021/jm800896z. PMID   18983141.
3. Forsman H, Li W, Levin NK, Karlsson R, Karlsson A, Dahlgren C, et al. (June 2025). "Activation and signaling characteristics of the hydroxy-carboxylic acid 3 receptor identified in human neutrophils through a microfluidic flow cell technique". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1872 (5) 119950. doi:10.1016/j.bbamcr.2025.119950. PMID   40194600.