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Psilocybin is a naturally occurring psychedelic prodrug compound produced by more than 200 species of fungi. The most potent are members of genus Psilocybe, such as P. azurescens, P. semilanceata, and P. cyanescens, but psilocybin has also been isolated from approximately a dozen other genera. Psilocybin is itself biologically inactive but is quickly converted by the body to psilocin, which has mind-altering effects similar, in some aspects, to those of lysergic acid diethylamide (LSD), mescaline, and dimethyltryptamine (DMT). In general, the effects include euphoria, visual and mental hallucinations, changes in perception, distorted sense of time, and perceived spiritual experiences. It can also cause adverse reactions such as nausea and panic attacks.
Psilocybe cubensis, commonly known as the magic mushroom, shroom, golden halo, cube, or gold cap, is a species of psilocybin mushroom of moderate potency whose principal active compounds are psilocybin and psilocin. It belongs to the fungus family Hymenogastraceae and was previously known as Stropharia cubensis. It is the best-known psilocybin mushroom due to its wide distribution and ease of cultivation. This mushroom being optimal for home cultivation specifically, as was suggested in the 1970s, is primarily what led to P. cubensis being the psilocybin mushroom species most common on the black market as a street drug.
Terence Kemp McKenna was an American ethnobotanist and mystic who advocated the responsible use of naturally occurring psychedelic plants. He spoke and wrote about a variety of subjects, including psychedelic drugs, plant-based entheogens, shamanism, metaphysics, alchemy, language, philosophy, culture, technology, ethnomycology, environmentalism, and the theoretical origins of human consciousness. He was called the "Timothy Leary of the '90s", "one of the leading authorities on the ontological foundations of shamanism", and the "intellectual voice of rave culture".
Psilocybin mushrooms, commonly known as magic mushrooms or shrooms, are a polyphyletic informal group of fungi that contain psilocybin, which turns into psilocin upon ingestion. Biological genera containing psilocybin mushrooms include Psilocybe, Panaeolus, Inocybe, Pluteus, Gymnopilus, and Pholiotina.
Psychedelic therapy refers to the proposed use of psychedelic drugs, such as psilocybin, MDMA, LSD, and ayahuasca, to treat mental disorders. As of 2021, psychedelic drugs are controlled substances in most countries and psychedelic therapy is not legally available outside clinical trials, with some exceptions.
Psilocin is a substituted tryptamine alkaloid and a serotonergic psychedelic substance. It is present in most psychedelic mushrooms together with its phosphorylated counterpart psilocybin. Psilocin is a Schedule I drug under the Convention on Psychotropic Substances. Acting on the 5-HT2A serotonin receptors, psilocin’s psychedelic effects are directly correlated with the drug’s occupancy at these receptor sites. The subjective mind-altering effects of psilocin are highly variable and are said to resemble those of LSD and DMT.
A smart shop is a retail establishment that specializes in the sale of psychoactive substances, usually including psychedelics, as well as related literature and paraphernalia. The name derives from the name "smart drugs", a class of drugs and food supplements intended to affect cognitive enhancements which are often sold in smart shops.
The stoned ape theory is a controversial theory first proposed by American ethnobotanist and mystic Terence McKenna in his 1992 book Food of the Gods. The theory claims that the transition from Homo erectus to Homo sapiens and the cognitive revolution was caused by the addition of psilocybin mushrooms, specifically the mushroom Psilocybe cubensis, into the human diet around 100,000 years ago. Using evidence largely based on studies from Roland L. Fischer et al. from the 1960s and 1970s, he attributed much of the mental strides made by humans during the cognitive revolution to the effects of psilocybin intake found by Fischer.
Psilocybe zapotecorum is a psilocybin mushroom which has psilocybin and psilocin as main active compounds. It is in the section Zapotecorum.
The legal status of unauthorised actions with psilocybin mushrooms varies worldwide. Psilocybin and psilocin are listed as Schedule I drugs under the United Nations 1971 Convention on Psychotropic Substances. Schedule I drugs are defined as drugs with a high potential for abuse or drugs that have no recognized medical uses. However, psilocybin mushrooms have had numerous medicinal and religious uses in dozens of cultures throughout history and have a significantly lower potential for abuse than other Schedule I drugs.
Steven Hayden Pollock was a mycologist who studied psychoactive mushrooms and published many articles on the potential of mushrooms to treat illness and improve quality of life.
This is an overview of the legality of ayahuasca by country. DMT, one of the active ingredients in ayahuasca, is classified as a Schedule I drug under the United Nations 1971 Convention on Psychotropic Substances, meaning that international trade in DMT is supposed to be closely monitored; use of DMT is supposed to be restricted to scientific research and medical use. Natural materials containing DMT, including ayahuasca, are not regulated under the 1971 Psychotropic Convention. The majority of the world's nations classify DMT as a scheduled drug; however, few countries seem to have laws specifically addressing the possession or use of ayahuasca.
Magic truffles are the sclerotia of psilocybin mushrooms that are not technically the same as "mushrooms". They are masses of mycelium that contain the fruiting body which contains the hallucinogenic chemicals psilocybin and psilocin.
Oregon Psilocybin Society is a nonprofit organization founded in 2016 with the direct intention of creating awareness around and laying a foundation for the legislation of psilocybin services, a sequence of supervised sessions which includes the use of psychedelic psilocybin mushrooms for adults in the U.S. state of Oregon. The founders of the society, Sheri Eckert and Tom Eckert, are the Architects and Chief Petitioners of Measure 109, Introducing an initiative to Oregon state voters for 2020. This legislation will create legal access to psilocybin assisted services to any individual over 21 years of age, upon passing a risk assessment for contraindications. Psilocybin assisted services will be provided on-site at a licensed facility by a licensed facilitator. The service progression would include, at minimum, a preparation session, a psilocybin administration session, and an integration session. All sessions would be conducted by trained facilitators.
Psilocybin therapy is the use of psilocybin in treating a range of mental health conditions, such as depression, anxiety, addictions, obsessive compulsive disorder, and psychosis. It is one of several forms of psychedelic therapy under study. Psilocybin was popularized as a psychedelic recreational drug in the 1970s and was classified as a Schedule I drug by the DEA. Research on psilocybin as a medical treatment was restricted until the 1990s because of the sociocultural fear of dependence on this drug. As of 2022, psilocybin is the most commonly researched psychedelic due to its safety and low potential for abuse and dependence. Clinical trials are being conducted at universities and there is evidence confirming the use of psilocybin in the treatment of depression, PTSD and end of life anxiety.
The movement to decriminalize psilocybin in the United States began in 2019 with Denver, Colorado, becoming the first city to decriminalize psilocybin in May of that year. The cities of Oakland and Santa Cruz, California, decriminalized psilocybin in June 2019 and January 2020, respectively. Washington, D.C., followed soon in November 2020, as did Somerville, Massachusetts, in January 2021, and then the neighboring Cambridge and Northampton in February 2021 and March 2021, respectively. Seattle, Washington, became the largest U.S. city on the growing list in October 2021. Detroit, Michigan, followed in November 2021.
Mind Medicine (MindMed) Inc., doing business as MindMed, is a New York-based biotechnology company that is currently developing clinical and therapeutic applications for psychedelic and, more broadly, psychoplastogenic drugs.
Entheogenic drugs have been used by various groups for thousands of years. There are numerous historical reports as well as modern, contemporary reports of indigenous groups using entheogens, chemical substances used in a religious, shamanic, or spiritual context.
Fun Guyz is a magic mushroom store chain mainly operating in Ontario, with at least 17 stores in the province and one in Quebec. Their business operates illegally, as sale and possession of magic mushrooms is illegal in Canada. These stores are frequently raided and their products confiscated. The raided stores usually reopen quickly after the seized merchandise has been replaced, with the exception of the five locations that have been permanently closed by local authorities.
Robin Lester Carhart-Harris is a British psychopharmacologist who is Ralph Metzner Distinguished Professor in the Department of Neurology at the University of California, San Francisco. Previously, he founded and was Head of the Centre for Psychedelic Research at Imperial College London.
References
- ↑ Heather Tal Murphy. "Are We Ready to Buy Magic Mushrooms Like They're Craft Beer?". Slate . Retrieved 1 September 2023.
- ↑ "Jamaica's Largest Psilocybin Grower Launches Luxury Retreats". Ethos. 2 August 2023. Retrieved 1 September 2023.
- ↑ Alex Irwin-Hunt (14 August 2023). "Jamaica's psychedelic ambitions: healing or trippin'?". fDi Intelligence . Retrieved 1 September 2023.
- ↑ Lara Goldstein (1 August 2023). "Jamaica Launches Organic Psilocybin Gummies & New Psychedelic Retreat". Benzinga. Retrieved 1 September 2023.
- ↑ Alexis Monteith (20 September 2023). "A wellness shift". Jamaica Observer . Retrieved 13 January 2024.
- ↑ Mattha Busby (30 June 2023). "How a Legal Loophole Made Jamaica a Magic Mushroom Paradise". Vice News . Retrieved 1 September 2023.