Opsona Therapeutics

Last updated
Opsona Therapeutics
Founded1 January 2004  OOjs UI icon edit-ltr-progressive.svg
Headquarters
Dublin   OOjs UI icon edit-ltr-progressive.svg
,
Republic of Ireland  OOjs UI icon edit-ltr-progressive.svg
Website www.opsona.com

Opsona Therapeutics was a drug development company specialising in the human immune system and new drugs and vaccines to prevent and treat autoimmune/inflammatory conditions, cancers and infectious diseases. [1] [2] [3]

Based in Ireland, Opsona was a spin-out from Trinity College Dublin (TCD). [4] Ireland is ranked highly in the world in immunology research, and TCD has been at the forefront of the field. [5]

Opsona's research was primarily focused on the role of Toll-like receptors (TLRs) and TLR signalling in human innate immunity. The company was founded in 2004 by three immunologists:

The company went into liquidation in 2019 after unsuccessful clinical trials, and failure to find a buyer for OPN-305.

Opsona's main investors were international and life-science focused:

Related Research Articles

<span class="mw-page-title-main">Trinity College Dublin</span> Sole college of the University of Dublin

Trinity College, officially The College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin, is the sole constituent college of the University of Dublin, a research university in Dublin, Ireland. Queen Elizabeth I issued a royal charter for the college in 1592 as "the mother of a university" that was modelled after the collegiate universities of both Oxford and Cambridge, but unlike these affiliated institutions, only one college was ever established; as such, the designations "Trinity College" and "University of Dublin" are usually synonymous for administrative purposes.

Dermot P. Kelleher FMedSci is the Dean of the Faculty of Medicine and Vice-President, Health at the University of British Columbia in Vancouver, Canada.

Dublin Molecular Medicine Centre (DMMC) was a charity set up in 2002, to create critical mass in molecular medicine research in Dublin, Ireland. Funding was provided by the Higher Education Authority.

In immunology, an adjuvant is a substance that increases or modulates the immune response to a vaccine. The word "adjuvant" comes from the Latin word adiuvare, meaning to help or aid. "An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune responses when used in combination with specific vaccine antigens."

<span class="mw-page-title-main">Trinity Business School, Trinity College Dublin</span>

Trinity Business School, (TBS) is part of the Trinity College Dublin and located on College Green, in Dublin, Ireland. Trinity Business School is triple accredited (AACSB/EQUIS/AMBA), a distinction that only holds for 0.6% of business schools worldwide. It offers programmes at undergraduate, postgraduate, MBA and Executive Education levels. In 2023 TBS was ranked as Ireland's best business school in the Financial Times Global MBA Ranking. At the same time, Trinity College Dublin ranked number 134 worldwide in the relevant Times Higher Education World University Rankings. The Eduniversal Best Masters ranking rates consistently all TBS graduate programmes among the 50 best worldwide.

Sir Gordon William Duff, is a British medical scientist and academic. He was Principal of St Hilda's College, Oxford, from 2014 to 2021. He was Lord Florey Professor of Molecular Medicine at the University of Sheffield from 1991 to 2014.

<span class="mw-page-title-main">Trinity Centre for Asian Studies</span>

The Trinity Centre for Asian Studies (TCAS) is a multidisciplinary teaching and research centre for East Asian scholarship at Trinity College in Dublin, Ireland.

Sir Adrian Vivian Sinton Hill, is an Irish vaccinologist, Director of the Jenner Institute and Lakshmi Mittal and Family Professor of Vaccinology at the University of Oxford, an honorary Consultant Physician in Infectious Diseases, and Fellow of Magdalen College, Oxford. Hill is a leader in the field of malaria vaccine development and was a co-leader of the research team which produced the Oxford–AstraZeneca COVID-19 vaccine, along with Professor Sarah Gilbert of the Jenner Institute and Professor Andrew Pollard of the Oxford Vaccine Group.

<span class="mw-page-title-main">Luke O'Neill (scientist)</span> Irish biochemist (born 1964)

Luke Anthony John O'Neill is an Irish biochemist. He has been a professor of biochemistry in the School of Biochemistry and Immunology at Trinity College Dublin since 2009.

Annie Curtis is an Irish immunologist at the Royal College of Surgeons in Ireland whose career has spanned academia, public sector and industry. She studies how the power of the body clock can be harnessed to control inflammatory diseases.

Jane Ohlmeyer,, is a historian and academic, specialising in early modern Irish and British history. She is the Erasmus Smith's Professor of Modern History (1762) at Trinity College Dublin and Chair of the Irish Research Council, which funds frontier research across all disciplines.

Linda F. Hogan is an Irish ethicist, ecumenist and academic, specialising in Christian ethics, political ethics, human rights, gender, and ecumenism. She is Professor of Ecumenics at Trinity College Dublin, where she was also its vice-provost from 2011 to 2016. She worked as a lecturer at the University of Chester and University of Leeds before joining the staff of Trinity College, Dublin.

Christine E. Loscher is a Professor of Biotechnology and Associate Dean for Research at Dublin City University. Loscher is director of the Health Technologies Research and Enterprise Hub, and she works on bioactive molecules for autoimmune diseases.

<span class="mw-page-title-main">Rose Anne Kenny</span> Irish geriatrician, neuroscientist and cardiologist

Rose Anne Kenny is an Irish geriatrician. She is the Regius Professor of Physic and a professor of medical gerontology at Trinity College Dublin (TCD), director of the Falls and Black-out Unit at St James's Hospital in Dublin, director of the Mercer's Institute for Successful Ageing and founding principal investigator for The Irish Longitudinal Study on Ageing (TILDA). She was admitted in 2014 to the Royal Irish Academy in recognition of academic excellence and achievement. Kenny is a fellow of Trinity College Dublin and of the Royal Colleges of Physicians of Ireland, London and Edinburgh.

Rocco Lupoi is an Italian lecturer, assistant professor and researcher in mechanical and manufacturing engineering at Trinity College Dublin, Ireland. He is an expert on cold spray additive manufacturing, selective laser melting, and similar deposition methods.

Sinéad M. Ryan is an Irish theoretical physicist and professor of Theoretical High Energy Physics at Trinity College Dublin. Her research covers "high-energy particle physics, and how particles in atoms such as quarks and gluons stick together".

Hazel Marguerite Dockrell is an Irish-born microbiologist and immunologist whose research has focused on immunity to the human mycobacterial diseases, leprosy and tuberculosis. She has spent most of her career at the London School of Hygiene and Tropical Medicine, where as of 2020 she is a professor of immunology. She was the first female president of the Royal Society of Tropical Medicine and Hygiene. Jimmy Whitworth of the Wellcome Trust describes her as "a marvellous ambassador for global health and research."

<span class="mw-page-title-main">Linda Doyle</span> Irish engineer, professor and academic leader

Linda E. Doyle is an Irish academic and educator who is the 45th provost and president of Trinity College Dublin (TCD), the university's chief officer. An electrical engineer, she has had a long academic career at Trinity, from the 1990s, most recently as Professor of Engineering and the Arts, in addition to holding other management roles such as Dean of Research. She has also led one telecommunications research centre at the university, and was the founding director of another, the multi-institution organisation known as CONNECT. Doyle has worked as a member of regulatory and advisory bodies in both Ireland, on broadband network strategy, and the UK, on mobile spectrum allocation. She is or has also been a director of public outreach projects such as Science Gallery Dublin and its international network, of two non-profit art galleries, and of two university spin-off companies.

John Gabriel Byrne was an Irish computer scientist and engineer. He founded the department of computer science in Trinity College Dublin, serving as its first head and professor, and has been referred to as "The Father of Computing in Ireland".

Cliona O’Farrelly is an Irish immunologist, with a background in comparative, liver and cancer immunology, focuses on the innate immune response to viruses to identify new or improved therapeutic strategies to control resistance to viral infection.

References

  1. "Ireland's got talent" . Retrieved 27 February 2018.
  2. "Sunday Business Post article" . Retrieved 27 February 2018.
  3. "Opsona Therapeutics Limited: Private Company Information - Bloomberg". investing.businessweek.com. Archived from the original on September 10, 2012. Retrieved 27 February 2018.
  4. "Emerging finalist: Mark Heffernan Opsona Therapeutics" . Retrieved 27 February 2018.
  5. Times Higher Education Supplement - QS World University Rankings 2007
  6. "Trinity team makes vaccine discovery". 4 May 2009. Retrieved 27 February 2018.
  7. Dublin, bbutler@tcd.ie, Trinity College. "Kingston Mills - Research : School of Biochemistry and Immunology : Trinity College Dublin, the University of Dublin, Ireland". www.tcd.ie. Retrieved 27 February 2018.{{cite web}}: CS1 maint: multiple names: authors list (link)
  8. "Article on the Trinity College Dublin website" . Retrieved 27 February 2018.
  9. "Opsona Therapeutics Closes EUR18M Funding - FierceBiotech". www.fiercebiotech.com. Retrieved 27 February 2018.
  10. "PR Newswire article" . Retrieved 27 February 2018.