PRB4

PRB4
Identifiers
Aliases	PRB4 , Po, proline-rich protein BstNI subfamily 4, proline rich protein BstNI subfamily 4
External IDs	OMIM: 180990; GeneCards: PRB4; OMA:PRB4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.2 Start 11,307,077 bp [1] End 11,310,436 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa epithelium of colon tonsil bone marrow liver urinary bladder skin of abdomen skin of leg blood lymph node n/a More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component extracellular region Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5545 n/a Ensembl ENSG00000274839 ENSG00000230657 n/a UniProt P10163 n/a RefSeq (mRNA) NM_002723 NM_001261399 n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 12: 11.31 – 11.31 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Basic salivary proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene. ^[3]

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. ^[3]

PRB4 is post-translationally cleaved into three different mature peptides:

• Protein N1
• Glycosylated protein A
• Peptide P-D (also known as proline-rich peptide IB-5)

References

1. ENSG00000230657 GRCh38: Ensembl release 89: ENSG00000274839, ENSG00000230657 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: PRB4 proline-rich protein BstNI subfamily 4".

Further reading

• Azen EA, Maeda N (1988). "Molecular Genetics of Human Salivary Proteins and Their Polymorphisms". Advances in Human Genetics 1. Vol. 17. pp. 141–199. doi:10.1007/978-1-4613-0987-1_5. ISBN   978-1-4612-8279-2. PMID   3055850.
• Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. doi:10.1007/BF00223503. PMID   6810092. S2CID   31373141.
• Lyons KM, Stein JH, Smithies O (1989). "Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over". Genetics. 120 (1): 267–78. doi:10.1093/genetics/120.1.267. PMC   1203497 . PMID   2851479.
• Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. doi: 10.1016/S0021-9258(17)39156-1 . PMID   2993301.
• Lyons KM, Azen EA, Goodman PA, Smithies O (1989). "Many Protein Products from a Few Loci: Assignment of Human Salivary Proline-Rich Proteins to Specific Loci". Genetics. 120 (1): 255–65. doi:10.1093/genetics/120.1.255. PMC   1203496 . PMID   3220251.
• Warner TF, Azen EA (1984). "Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract". Am. Rev. Respir. Dis. 130 (1): 115–8. doi:10.1164/arrd.1984.130.1.115 (inactive 12 July 2025). PMID   6377992.
• Saitoh E, Isemura S, Sanada K (1983). "Complete amino acid sequence of a basic proline-rich peptide, P-D, from human parotid saliva". J. Biochem. 93 (2): 495–502. doi:10.1093/jb/93.3.883. PMID   6841349.
• Kauffman DL, Keller PJ, Bennick A, Blum M (1993). "Alignment of amino acid and DNA sequences of human proline-rich proteins". Crit. Rev. Oral Biol. Med. 4 (3–4): 287–92. doi: 10.1177/10454411930040030501 . PMID   8373986.
• Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome. 4 (1): 3–14. doi:10.1007/BF00364656. PMID   8422499. S2CID   24058984.
• Azen EA, Amberger E, Fisher S, et al. (1996). "PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins". Am. J. Hum. Genet. 58 (1): 143–53. PMC   1914931 . PMID   8554050.
• Castle AM, Castle JD (1998). "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell. 9 (3): 575–83. doi:10.1091/mbc.9.3.575. PMC   25286 . PMID   9487127.
• Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. doi: 10.1046/j.1432-1327.2001.02241.x . PMID   11422372.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Vallat JM, Magy L, Lagrange E, et al. (2007). "Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance". Acta Neuropathol. 113 (4): 443–9. doi:10.1007/s00401-007-0196-7. PMID   17294201. S2CID   42561185.