PRB4

PRB4
Identifiers
Aliases	PRB4 , Po, proline-rich protein BstNI subfamily 4, proline rich protein BstNI subfamily 4
External IDs	OMIM: 180990; GeneCards: PRB4; OMA:PRB4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	11,310,436 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; epithelium of colon; ; tonsil; ; bone marrow; ; liver; ; urinary bladder; ; skin of abdomen; ; skin of leg; ; blood; ; lymph node;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function ;
Cellular component	extracellular region ;
Biological process	biological process ;
	Sources:Amigo / QuickGO
Orthologs
	5545
	n/a
	ENSG00000274839 ; ENSG00000230657
	n/a
	P10163
	n/a
	NM_002723 ; NM_001261399
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated November 03, 2024

Basic salivary proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene.^[3]

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.^[3]

PRB4 is post-translationally cleaved into three different mature peptides:

Protein N1
Glycosylated protein A
Peptide P-D (also known as proline-rich peptide IB-5)

Related Research Articles

<span class="mw-page-title-main">Chromosome 12</span> Human chromosome

Chromosome 12 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 12 spans about 133 million base pairs and represents between 4 and 4.5 percent of the total DNA in cells.

Trefoil factor 2 is a protein that in humans is encoded by the TFF2 gene.

Large proline-rich protein BAT3 is a protein that in humans is encoded by the BAT3 gene.

Cystatin-S is a protein that in humans is encoded by the CST4 gene.

Histatin 3, also known as HTN3, is a protein which in humans is encoded by the HTN3 gene.

Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.

Statherin is a protein in humans that is encoded by the STATH gene. It prevents the precipitation of calcium phosphate in saliva, maintaining a high calcium level in saliva available for remineralisation of tooth enamel and high phosphate levels for buffering.

Protein-L-isoaspartate(D-aspartate) O-methyltransferase is an enzyme that in humans is encoded by the PCMT1 gene.

Cystatin-SN is a protein that in humans is encoded by the CST1 gene.

Cystatin-SA is a protein that in humans is encoded by the CST2 gene.

Basic salivary proline-rich protein 1 is a protein that in humans is encoded by the PRB1 gene.

Histatin-1 is a protein that in humans is encoded by the HTN1 gene.

Oviduct-specific glycoprotein also known as oviductal glycoprotein(OGP) or estrogen-dependent oviduct protein, oviductin or mucin-9 is a protein that in humans is encoded by the OVGP1 gene.

Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene.

Cathepsin W is a protein that in humans is encoded by the CTSW gene.

Prolyl 4-hydroxylase subunit alpha-2 is an enzyme that in humans is encoded by the P4HA2 gene.

Amyloid beta A4 precursor protein-binding family B member 3 is a protein that in humans is encoded by the APBB3 gene.

Basic salivary proline-rich protein 3 is a protein that in humans is encoded by the PRB3 gene.

Salivary acidic proline-rich phosphoprotein 1/2 is a protein that in humans is encoded by the PRH1 gene.

Proline-rich protein HaeIII subfamily 2 is a protein that in humans is encoded by the PRH2 gene.

References

1 2 3 ENSG00000230657 GRCh38: Ensembl release 89: ENSG00000274839, ENSG00000230657 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: PRB4 proline-rich protein BstNI subfamily 4".

Azen EA, Maeda N (1988). "Molecular Genetics of Human Salivary Proteins and Their Polymorphisms". Advances in Human Genetics 1. Vol. 17. pp. 141–199. doi:10.1007/978-1-4613-0987-1_5. ISBN 978-1-4612-8279-2. PMID 3055850.
Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. doi:10.1007/BF00223503. PMID 6810092. S2CID 31373141.
Lyons KM, Stein JH, Smithies O (1989). "Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over". Genetics. 120 (1): 267–78. doi:10.1093/genetics/120.1.267. PMC 1203497 . PMID 2851479.
Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. doi: 10.1016/S0021-9258(17)39156-1 . PMID 2993301.
Lyons KM, Azen EA, Goodman PA, Smithies O (1989). "Many Protein Products from a Few Loci: Assignment of Human Salivary Proline-Rich Proteins to Specific Loci". Genetics. 120 (1): 255–65. doi:10.1093/genetics/120.1.255. PMC 1203496 . PMID 3220251.
Warner TF, Azen EA (1984). "Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract". Am. Rev. Respir. Dis. 130 (1): 115–8. doi:10.1164/arrd.1984.130.1.115 (inactive 1 November 2024). PMID 6377992.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
Saitoh E, Isemura S, Sanada K (1983). "Complete amino acid sequence of a basic proline-rich peptide, P-D, from human parotid saliva". J. Biochem. 93 (2): 495–502. doi:10.1093/jb/93.3.883. PMID 6841349.
Kauffman DL, Keller PJ, Bennick A, Blum M (1993). "Alignment of amino acid and DNA sequences of human proline-rich proteins". Crit. Rev. Oral Biol. Med. 4 (3–4): 287–92. doi: 10.1177/10454411930040030501 . PMID 8373986.
Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome. 4 (1): 3–14. doi:10.1007/BF00364656. PMID 8422499. S2CID 24058984.
Azen EA, Amberger E, Fisher S, et al. (1996). "PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins". Am. J. Hum. Genet. 58 (1): 143–53. PMC 1914931 . PMID 8554050.
Castle AM, Castle JD (1998). "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell. 9 (3): 575–83. doi:10.1091/mbc.9.3.575. PMC 25286 . PMID 9487127.
Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. doi: 10.1046/j.1432-1327.2001.02241.x . PMID 11422372.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Vallat JM, Magy L, Lagrange E, et al. (2007). "Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance". Acta Neuropathol. 113 (4): 443–9. doi:10.1007/s00401-007-0196-7. PMID 17294201. S2CID 42561185.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000230657 GRCh38: Ensembl release 89: ENSG00000274839, ENSG00000230657 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] 1 2 "Entrez Gene: PRB4 proline-rich protein BstNI subfamily 4".

[1]

[2]

[3]

PRB4

Related Research Articles

References

Further reading