PSG2

Last updated

Function

Human pregnancy-specific glycoproteins (PSGs) are a family of proteins synthesized in large quantities by the placental trophoblast and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has shown that PSG forms a subset of the carcinoembryonic antigen (CEA) gene family that belongs to the immunoglobulin superfamily genes. Members of the CEA family consist of a single N domain structurally similar to the immunoglobulin variable domain, followed by a variable number of constant immunoglobulin-like A and/or B domains. Most PSGs have the Argglyasp (RGD) motif in the N-terminal domain. It has been shown to act as an adhesion recognition signal for some integrins. [1]

Contents

PSG2
Identifiers
Aliases PSG2 , CEA, PSBG2, PSG1, pregnancy specific beta-1-glycoprotein 2
External IDs OMIM: 176391; GeneCards: PSG2; OMA:PSG2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

5670

n/a

Ensembl

ENSG00000242221

n/a

UniProt

P11465

n/a

RefSeq (mRNA)

NM_031246

n/a

RefSeq (protein)

NP_112536

n/a

Location (UCSC) Chr 19: 43.06 – 43.08 Mb n/a
PubMed search [3] n/a
Wikidata
View/Edit Human

Pregnancy-specific beta-1-glycoprotein 2 is a protein that in humans is encoded by the PSG2 gene. [4] [5]

Related Research Articles

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References

  1. ↑ Teglund, Stephan; Olsen, Anne; Khan, Wasif Noor; Frångsmyr, Lars; Hammarström, Sten (October 1994). "The Pregnancy-Specific Glycoprotein (PSG) Gene Cluster on Human Chromosome 19: Fine Structure of the 11 PSG Genes and Identification of 6 New Genes Forming a Third Subgroup within the Carcinoembryonic Antigen (CEA) Family". Genomics. 23 (3): 669–684. doi:10.1006/geno.1994.1556. PMID   7851896.
  2. 1 2 3 GRCh38: Ensembl release 89: ENSG00000242221 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ Leslie KK, Watanabe S, Lei KJ, Chou DY, Plouzek CA, Deng HC, Torres J, Chou JY (Aug 1990). "Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole". Proceedings of the National Academy of Sciences of the United States of America. 87 (15): 5822–6. Bibcode:1990PNAS...87.5822L. doi: 10.1073/pnas.87.15.5822 . PMC   54420 . PMID   2377620.
  5. ↑ "Entrez Gene: PSG2 pregnancy specific beta-1-glycoprotein 2".

Further reading


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