PYLIS downstream sequence

Last updated
Pyrrolysine insertion sequence 1 (mtmB)
PHYLIS SS.png
Predicted secondary structure of PYLIS 1 RNA.
Identifiers
SymbolPYLIS_1
Rfam RF01982
Other data
RNA typePresumed cis-regulatory element
Domain(s) Archaea and Bacteria
PDB structures PDBe
Pyrrolysine insertion sequence mtbB
Identifiers
SymbolPYLIS_2
Rfam RF02509
Other data
PDB structures PDBe
Pyrrolysine insertion sequence mttB
Identifiers
SymbolPYLIS_3
Rfam RF02510
Other data
PDB structures PDBe
Pyrrolysine insertion sequence TetR
Identifiers
SymbolPYLIS_4
Rfam RF02511
Other data
PDB structures PDBe
Pyrrolysine insertion sequence transposase 1
Identifiers
SymbolPYLIS_5
Rfam RF02512
Other data
PDB structures PDBe
Pyrrolysine insertion sequence transposase 2
Identifiers
SymbolPYLIS_6
Rfam RF02513
Other data
PDB structures PDBe

In biology, the PYLIS downstream sequence (PYLIS: pyrrolysine insertion sequence) is a stem-loop structure that appears on some mRNA sequences. This structural motif was previously thought to cause the UAG (amber) stop codon to be translated to the amino acid pyrrolysine instead of ending the protein translation. [1] [2] [3] However, it has been shown that PYLIS has no effect upon the efficiency of the UAG suppression, [4] hence even its name is, in fact, incorrect.

Contents

See also

References

  1. ↑ Namy O, Rousset JP, Napthine S, Brierley I (2004). "Reprogrammed genetic decoding in cellular gene expression". Molecular Cell. 13 (2): 157–168. doi: 10.1016/S1097-2765(04)00031-0 . PMID   14759362.
  2. ↑ Théobald-Dietrich A, Giegé R, Rudinger-Thirion J (2005). "Evidence for the existence in mRNAs of a hairpin element responsible for ribosome dependent pyrrolysine insertion into proteins". Biochimie. 87 (9–10): 813–817. doi:10.1016/j.biochi.2005.03.006. PMID   16164991.
  3. ↑ Zhang Y, Baranov PV, Atkins JF, Gladyshev VN (May 2005). "Pyrrolysine and selenocysteine use dissimilar decoding strategies". J. Biol. Chem. 280 (21): 20740–20751. doi: 10.1074/jbc.M501458200 . PMID   15788401.
  4. ↑ Namy, Olivier; Zhou, Yu; Gundllapalli, Sarath; Polycarpo, Carla R.; Denise, Alain; Rousset, Jean-Pierre; Söll, Dieter; Ambrogelly, Alexandre (November 2007). "Adding pyrrolysine to the Escherichia coli genetic code". FEBS Letters . 581 (27): 5282–5288. doi: 10.1016/j.febslet.2007.10.022 . PMID   17967457.

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