Panosteitis, sometimes shortened to pano among breeders, [1] is an occasionally seen long bone condition in large breed dogs. It manifests with sudden, unexplained pain and lameness that may shift from leg to leg, usually between 5 and 14 months of age, earning the nickname "growing pains. " [2] Signs such as fever, weight loss, anorexia, and lethargy can also be seen. The cause is unknown, but genetics, stress, infection, metabolism, or an autoimmune component may be factors. [3] It has also been suggested that rapid growth and high-protein food are involved in the pathogenesis. [4] Whole blood analysis may show an elevated white blood cell count; this finding lends support to the theory that panosteitis is due to an infection. [5]
Panosteitis is characterized histologically by an increase in activity of osteoblasts and fibroblasts in the periosteum, endosteum and bone marrow, resulting in fibrosis and the formation of connective tissue in the medullary cavity of the affected bone. Pain may be caused by increased pressure in the medullary cavity and the stimulation of pain receptors in the periosteum. [6]
The humerus is most commonly affected. [7] Males are more commonly affected than females. [8]
Diagnosis is often a diagnosis of exclusion, meaning that other possible causes of lameness have been ruled out, such as hypertrophic osteodystrophy and osteochondrosis dissecans. History, signalment, and clinical signs can help a veterinarian form a presumptive diagnosis. On physical exam, the dog may display signs of pain on palpation of the long bones of the limbs. X-rays may show an increased density in the medullary cavity of the affected bones, often near the nutrient foramen (where the blood vessels enter the bone). This evidence may not be present for up to ten days after lameness begins. [9]
Treatment consists of alleviating the pain and inflammation so that the dog is comfortable. This is achieved with the use of analgesics and anti-inflammatory drugs, like carprofen. Steroids may be given in more severe cases to reduce inflammation. It is also recommended to limit physical activity during treatment to prevent exacerbating the condition with high impacts. [10] Lameness usually goes away after days to weeks without additional treatment. Recurrences up to the age of two years may occur. [9] Larger breeds, such as German Shepherd Dogs, Golden Retrievers, Basset Hounds, Dobermanns, Labrador Retrievers, and Rottweilers, are more prone to this problem. [11] There has been one suspected case of panosteitis in a fast-growing six-month-old camel with a shifting leg lameness. [12]
Panosteitis is also referred to as eosinophilic panosteitis, enostosis, endosteal proliferation of new bone, and eopan.
Gastric dilatation volvulus (GDV), also known as gastric dilation, twisted stomach, or gastric torsion, is a medical condition that affects dogs and rarely cats and guinea pigs, in which the stomach becomes overstretched and rotated by excessive gas content. The condition also involves compression of the diaphragm and caudal vena cavae. The word bloat is often used as a general term to mean gas distension without stomach torsion, or to refer to GDV.
Neutering, from the Latin neuter, is the removal of a non-human animal's reproductive organ, either all of it or a considerably large part. The male-specific term is castration, while spaying is usually reserved for female animals. Colloquially, both terms are often referred to as fixing. In male horses, castrating is referred to as gelding. An animal that has not been neutered is sometimes referred to as entire or intact. Often the term neuter[ing] is used to specifically mean castration, e.g. in phrases like "spay and neuter".
Onychectomy, popularly known as declawing, is an operation to remove an animal's claws surgically by means of the amputation of all or part of the distal phalanges, or end bones, of the animal's toes. Because the claw develops from germinal tissue within the third phalanx, amputation of the bone is necessary to fully remove the claw. The terms onychectomy and declawing imply mere claw removal, but a more appropriate description would be phalangectomy, excision of toe bone.
Skin disorders are among the most common health problems in dogs, and have many causes. The condition of a dog's skin and coat is also an important indicator of its general health. Skin disorders of dogs vary from acute, self-limiting problems to chronic or long-lasting problems requiring life-time treatment. Skin disorders may be primary or secondary in nature, making diagnosis complicated.
A mastocytoma or mast cell tumor is a type of round-cell tumor consisting of mast cells. It is found in humans and many animal species; it also can refer to an accumulation or nodule of mast cells that resembles a tumor.
The health of dogs is a well studied area in veterinary medicine.
Carprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the carbazole and propionic acid class that was previously for use in humans and animals but is now only available to veterinarians for prescribing as a supportive treatment for various conditions in animals. Carprofen reduces inflammation by inhibition of COX-1 and COX-2; its specificity for COX-2 varies from species to species. Marketed under many brand names worldwide, carprofen is used as a treatment for inflammation and pain, including joint pain and postoperative pain.
Phycomycosis is an uncommon condition affecting the gastrointestinal tract and skin, most commonly found in dogs and horses. The condition is caused by various molds, with individual forms including pythiosis, zygomycosis, and lagenidiosis. Pythiosis, the most common type, is caused by Pythium, a type of water mould. Zygomycosis can be caused by two types of zygomycetes: Entomophthorales and Mucorales. The latter type of zygomycosis is also referred to as mucormycosis. Lagenidiosis is caused by a Lagenidium species, which like Pythium is a water mould. Since both pythiosis and lagenidiosis are caused by organisms from the Oomycetes and not the kingdom fungi, they are sometimes collectively referred to as oomycosis.
Pythiosis is a rare and deadly tropical disease caused by the oomycete Pythium insidiosum. Long regarded as being caused by a fungus, the causative agent was not discovered until 1987. It occurs most commonly in horses, dogs, and humans, with isolated cases in other large mammals. The disease is contracted after exposure to stagnant fresh water such as swamps, ponds, lakes, and rice paddies. P. insidiosum is different from other members of the genus in that human and horse hair, skin, and decaying animal and plant tissue are chemoattractants for its zoospores. Additionally, it is the only member in the genus known to infect mammals, while other members are pathogenic to plants and are responsible for some well-known plant diseases.
Hypertrophic osteopathy is a bone disease secondary to cancer in the lungs.
Hypertrophic Osteodystrophy (HOD) is a bone disease that occurs most often in fast-growing large and giant breed dogs; however, it also affects medium breed animals like the Australian Shepherd. The disorder is sometimes referred to as metaphyseal osteopathy, and typically first presents between the ages of 2 and 7 months. HOD is characterized by decreased blood flow to the metaphysis leading to a failure of ossification and necrosis and inflammation of cancellous bone. The disease is usually bilateral in the limb bones, especially the distal radius, ulna, and tibia.
Granulomatous meningoencephalitis (GME) is an inflammatory disease of the central nervous system (CNS) of dogs and, rarely, cats. It is a form of meningoencephalitis. GME is likely second only to encephalitis caused by canine distemper virus as the most common cause of inflammatory disease of the canine CNS. The disease is more common in female dogs of young and middle age. It has a rapid onset. The lesions of GME exist mainly in the white matter of the cerebrum, brainstem, cerebellum, and spinal cord. The cause is only known to be noninfectious and is considered at this time to be idiopathic. Because lesions resemble those seen in allergic meningoencephalitis, GME is thought to have an immune-mediated cause, but it is also thought that the disease may be based on an abnormal response to an infectious agent. One study searched for viral DNA from canine herpesvirus, canine adenovirus, and canine parvovirus in brain tissue from dogs with GME, necrotizing meningoencephalitis, and necrotizing leukoencephalitis, but failed to find any.
Wobbler disease is a catchall term referring to several possible malformations of the cervical vertebrae that cause an unsteady (wobbly) gait and weakness in dogs and horses. A number of different conditions of the cervical (neck) spinal column cause similar clinical signs. These conditions may include malformation of the vertebrae, intervertebral disc protrusion, and disease of the interspinal ligaments, ligamenta flava, and articular facets of the vertebrae. Wobbler disease is also known as cervical vertebral instability (CVI), cervical spondylomyelopathy (CSM), and cervical vertebral malformation (CVM). In dogs, the disease is most common in large breeds, especially Great Danes and Doberman Pinschers. In horses, it is not linked to a particular breed, though it is most often seen in tall, race-bred horses of Thoroughbred or Standardbred ancestry. It is most likely inherited to at least some extent in dogs and horses.
A vaccine-associated sarcoma (VAS) or feline injection-site sarcoma (FISS) is a type of malignant tumor found in cats which has been linked to certain vaccines. VAS has become a concern for veterinarians and cat owners alike and has resulted in changes in recommended vaccine protocols. These sarcomas have been most commonly associated with rabies and feline leukemia virus vaccines, but other vaccines and injected medications have also been implicated.
Vaccination of dogs is the practice of animal vaccination applied to dogs. Programs in this field have contributed both to the health of dogs and to the public health. In countries where routine rabies vaccination of dogs is practiced, for example, rabies in humans is reduced to a very rare event.
Cancer is the leading cause of death in dogs. It is estimated that 1 in 3 domestic dogs will develop cancer, which is the same incidence of cancer among humans. Dogs can develop a variety of cancers and most are very similar to those found in humans. Dogs can develop carcinomas of epithelial cells and organs, sarcomas of connective tissues and bones, and lymphomas or leukemias of the circulatory system. Selective breeding of dogs has led certain pure-bred breeds to be at high-risk for specific kinds of cancer.
Veterinary chiropractic, also known as animal chiropractic, is chiropractic for animals – a type of spinal manipulation. Veterinary chiropractors typically treat horses, racing greyhounds, and pets. Veterinary chiropractic is a controversial method due to a lack of evidence as to the efficacy of chiropractic methods. Contrary to traditional medicine, chiropractic therapies are alternative medicine. There is some degree of risk associated with even skilled manipulation in animals as the potential for injury exists with any technique used. The founder of chiropractic, Daniel David Palmer, used the method on animals, partly to challenge claims that the placebo effect was responsible for favorable results in humans. Chiropractic treatment of large animals dates back to the early 1900s. As of 2019, many states in the US provide statutory or regulatory guidelines for the practice of chiropractic and related treatments on animals, generally requiring some form of veterinary involvement.
Exercise-induced collapse (EIC) is a genetic disorder that causes dogs of certain breeds to collapse after a period of intense exercise. The breeds affected are primarily sporting dogs.
Physical therapy for canines adapts human physical therapy techniques to increase function and mobility of joints and muscles in animals. Animal rehabilitation can reduce pain and enhance recovery from injury, surgery, degenerative diseases, age-related diseases, and obesity.