Paul J. Tesar

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Paul J. Tesar
Paul Tesar, Crain's 40 under 40 (2019).jpg
Born
Cleveland, Ohio, US
Education
Known for
Awards
Scientific career
Fields
Institutions
Doctoral advisors
Website tesarlab.com

Paul J. Tesar is an American developmental biologist. He is the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics at Case Western Reserve University School of Medicine. His research is focused on regenerative medicine.

Contents

Early life and education

Tesar was born in Cleveland, Ohio. [7] He graduated with a BSc in biology from Case Western Reserve University in 2003. As part of the National Institutes of Health Oxford-Cambridge Scholar Program, he earned a PhD in 2007. [8]

Career

While a graduate student, Tesar published a paper describing epiblast-derived stem cells, a new type of pluripotent stem cell, [1] research for which he received both the Beddington Medal of the British Society for Developmental Biology [5] and the Harold M. Weintraub Award of the Fred Hutchinson Cancer Research Center. [9]

In 2010 he returned to Case Western Reserve University School of Medicine to teach. [10] In 2014 he was appointed to the Dr. Donald and Ruth Weber Goodman chair in innovative therapeutics. [11]

Research

Tesar developed methods to generate and grow oligodendrocytes and oligodendrocyte progenitor cells (OPCs) from pluripotent stem cells and skin cells. [12] [13] He also made human brain organoids containing human myelin, called oligocortical spheroids. [14] [15] Tesar identified drugs that stimulate myelin regeneration and reverse paralysis in mice with multiple sclerosis. [16] Tesar also identified CRISPR and antisense oligonucleotide therapeutics that restored myelination and extended the lifespan of mice with Pelizaeus–Merzbacher disease. [17] [18] [19]

Awards


References

  1. 1 2 Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, et al. (July 2007). "New cell lines from mouse epiblast share defining features with human embryonic stem cells". Nature. 448 (7150): 196–9. Bibcode:2007Natur.448..196T. doi:10.1038/nature05972. PMID   17597760. S2CID   4430584.
  2. ↑ Najm, Fadi J.; Madhavan, Mayur; Zaremba, Anita; Shick, Elizabeth; Karl, Robert T.; Factor, Daniel C.; Miller, Tyler E.; Nevin, Zachary S.; Kantor, Christopher; Sargent, Alex; Quick, Kevin L. (June 2015). "Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo". Nature. 522 (7555): 216–220. Bibcode:2015Natur.522..216N. doi:10.1038/nature14335. ISSN   1476-4687. PMC   4528969 . PMID   25896324.
  3. ↑ Elitt, Matthew S.; Barbar, Lilianne; Shick, H. Elizabeth; Powers, Berit E.; Maeno-Hikichi, Yuka; Madhavan, Mayur; Allan, Kevin C.; Nawash, Baraa S.; Gevorgyan, Artur S.; Hung, Stevephen; Nevin, Zachary S.; Olsen, Hannah E.; Hitomi, Midori; Schlatzer, Daniela M.; Zhao, Hien T.; Swayze, Adam; LePage, David F.; Jiang, Weihong; Conlon, Ronald A.; Rigo, Frank; Tesar, Paul J. (July 1, 2020). "Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease". Nature. 585 (7825): 397–403. Bibcode:2020Natur.585..397E. doi:10.1038/s41586-020-2494-3. PMC   7810164 . PMID   32610343.
  4. 1 2 "Harold M. Weintraub Awardees from 2001-2014" (PDF). Archived (PDF) from the original on November 1, 2019. Retrieved November 1, 2019.
  5. 1 2 3 "The Beddington Medal". BSDB - British Society for Developmental Biology. Archived from the original on January 3, 2014.
  6. ↑ "Paul Tesar Named 2017 NYSCF - Robertson Stem Cell Prize Recipient". Archived from the original on November 1, 2019. Retrieved November 1, 2019.
  7. ↑ "The BriefCase". The Observer. September 17, 2004.[ permanent dead link ]
  8. ↑ "Tesar '03 Continues to Excel – International Biomedical Alliance". Archived from the original on May 22, 2022. Retrieved January 18, 2020.
  9. ↑ "Paul Tesar – International Biomedical Alliance". Archived from the original on May 22, 2022. Retrieved November 20, 2019.
  10. ↑ "School of Medicine faculty member receives prestigious award for stem cell research". The Daily. February 5, 2015. Archived from the original on December 4, 2019.
  11. ↑ "More efficiently generating brain stem cells: Technique improves understanding of myelin disease". ScienceDaily. Archived from the original on November 1, 2019. Retrieved November 1, 2019.
  12. ↑ "Study: New process converts skin cells into brain cells". CBS News. April 15, 2013. Archived from the original on November 1, 2019.
  13. ↑ "Ordinary skin cells morphed into functional brain cells". ScienceDaily. Archived from the original on September 6, 2015.
  14. ↑ Madhavan M, Nevin ZS, Shick HE, Garrison E, et al. (September 2018). "Induction of myelinating oligodendrocytes in human cortical spheroids". Nature Methods. 15 (9): 700–06. doi:10.1038/s41592-018-0081-4. ISSN   1548-7105. PMC   6508550 . PMID   30046099.
  15. ↑ "New method adds missing functionality to brain organoids: Protocol adds a new cell type enabling myelination in human 'mini-brains' for laboratory research". ScienceDaily. Archived from the original on November 1, 2019.
  16. ↑ "Drugs stimulate body's own stem cells to replace the brain cells lost in multiple sclerosis". ScienceDaily. Archived from the original on January 12, 2016.
  17. ↑ Elitt, Matthew S.; Barbar, Lilianne; Shick, H. Elizabeth; Powers, Berit E.; Maeno-Hikichi, Yuka; Madhavan, Mayur; Allan, Kevin C.; Nawash, Baraa S.; Nevin, Zachary S.; Olsen, Hannah E.; Hitomi, Midori (December 31, 2018). "Therapeutic suppression of proteolipid protein rescues Pelizaeus-Merzbacher Disease in mice". bioRxiv   10.1101/508192 .
  18. ↑ "Research finds new approach to treating certain neurological diseases". MedicalXpress. July 1, 2020. Retrieved July 1, 2020. Their research was published online July 1 in the journal Nature. "The pre-clinical results were profound. PMD mouse models that typically die within a few weeks of birth were able to live a full lifespan after treatment," said Paul Tesar
  19. ↑ Elitt, Matthew S.; Barbar, Lilianne; Shick, H. Elizabeth; Powers, Berit E.; Maeno-Hikichi, Yuka; Madhavan, Mayur; Allan, Kevin C.; Nawash, Baraa S.; Gevorgyan, Artur S.; Hung, Stevephen; Nevin, Zachary S. (July 1, 2020). "Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease". Nature. 585 (7825): 397–403. Bibcode:2020Natur.585..397E. doi:10.1038/s41586-020-2494-3. ISSN   1476-4687. PMC   7810164 . PMID   32610343.
  20. ↑ "NYSCF - Robertson Investigator Wins International Stem Cell Award". Archived from the original on November 1, 2019. Retrieved November 1, 2019.
  21. ↑ "The ISSCR Announces 2015 Recipients of the McEwen Award for Innovation, the ISSCR-BD Biosciences Outstanding Young Investigator, and the ISSCR Public Service Awards, 20 January, 2015". isscr.org. Archived from the original on April 16, 2021. Retrieved May 1, 2020.
  22. ↑ "Senior Members List". National Academy of Inventors . Retrieved June 24, 2022.
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