Plot summary
The novel Pharmakon is divided into three parts. The first part of the novel, titled "Book 1", takes place in the 1950s and centers around Will Friedrich; a middle aged, nontenured professor of psychology at Yale University. Though extremely smart and known around campus for his ability to take a set of data and "calculate the standard deviation in his head", Will is having a hard time figuring out an idea to climb the social ladder into the upper circles of the Yale elite. This all changes when will overhears Dr. Bunny Winton about an exotic plant called "gai kau dong" or, "The Way Home". She describes how this plant has been used by a native tribe in New Guinea to calm people after traumatic events. He and Winton begin testing on the same plants used by the New Guinea tribe. After isolating the active ingredient in the plant, Winton and Friedrich test the drug on rats and experience positive results.
Professor is an academic rank at universities and other post-secondary education and research institutions in most countries. Literally, professor derives from Latin as a "person who professes" being usually an expert in arts or sciences, a teacher of the highest rank.
A campus is traditionally the land on which a college or university and related institutional buildings are situated. Usually a college campus includes libraries, lecture halls, residence halls, student centers or dining halls, and park-like settings.
New Guinea is a large island separated by a shallow sea from the rest of the Australian continent. It is the world's second-largest island, after Greenland, covering a land area of 785,753 km2 (303,381 sq mi), and the largest wholly or partly within the Southern Hemisphere and Oceania.
One of their test subjects, Casper Gedsic, is originally described as a "bearded with pimples and peach fuzz, too shy to look a person in the eye." almost immediately begins to see a change; Casper's new found confidence enables him to clean up his appearance and befriend Whitney Bouchard, a rich, Yale football player.
After the drug trial concludes, Friedrich received a call from an intoxicated Whitney, talking about how Casper had changed ever since he stopped taking his medication and how he had created a list of everybody he blamed for his current state of despair, with Friedrich and Dr. Winton being at the top. Casper appears at Friedrich's house while Will was outside with his wife and children. With a gun at his side, Casper begins to approach, but then changes his mind and leaves.
The police arrive at Winton's home to see that Bunny Winton had been shot dead and her husband had been beaten in paralysis. The police immediately rush back to Friedrich's house to protect him and his family in case Casper came back. As Friedrich was talking to the police and everybody was speculating why Casper may have left them alone at first, Will's youngest son, Jack, is found drowned in a birdbath in the garden outside.
"Book II" begins approximately seven years after the conclusion of the first part. Will Friedrich has moved his family away from the New England area to Rutgers University in New Jersey in an attempt to start over away from the Casper incident. Casper was sentenced to a lengthy term in the Connecticut State Hospital for the criminally insane.
Rutgers, The State University of New Jersey, commonly referred to as Rutgers University, Rutgers, or RU, is a public research university in New Jersey. It is the largest institution of higher education in New Jersey.
Connecticut is the southernmost state in the New England region of the United States. As of the 2010 Census, it has the highest per-capita income, Human Development Index (0.962), and median household income in the United States. It is bordered by Rhode Island to the east, Massachusetts to the north, New York to the west, and Long Island Sound to the south. Its capital is Hartford and its most populous city is Bridgeport. It is part of New England, although portions of it are often grouped with New York and New Jersey as the Tri-state area. The state is named for the Connecticut River which approximately bisects the state. The word "Connecticut" is derived from various anglicized spellings of an Algonquian word for "long tidal river".
The rest of the story is told from Zach's perspective. At one point, young Zach is left home under the care of his irresponsible older sister, and, while setting up a lemonade stand, Casper arrives and takes Zach to a remote lake for "swimming lessons", and allows Zach to fall into the water. Zach begins to drown, but Casper saves him and brings him home.
Casper had recently escaped from the mental hospital with plans on exacting revenge on Will Friendrich. After all these years, Casper was convinced that it was Friedrich's fault that he felt depressed again once he stopped taking "The Way Home". When Zach gets dropped off at his house, his parents are frantically searching for him with help from the police. They soon are able to realize that it was Casper who had taken Zach "swimming", but they are dumbfounded on why he would let Zach live. After about a week of searching by the police, they are finally able to track down Casper once again and place him in a higher security mental hospital, which he never escapes from for the remainder of his life.
Though Zach was relatively safe, this event traumatized him for the rest of his life. "Book 3" begins 21 years after Zach goes to college, going through cocaine withdrawal. The reader learns that Zach dropped out of Yale and moved to Los Angeles to become a screenwriter. He hasn't talked to a majority of his family for years, especially his parents. His attempt at making contact goes horribly awry when his father sees him and recoils, thinking that Zach is just there to rob them. This enrages Zach and he storms off and goes to live with an old friend in the city, never speaking to his parents again.
Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug. It is commonly snorted, inhaled as smoke, or dissolved and injected into a vein. Mental effects may include loss of contact with reality, an intense feeling of happiness, or agitation. Physical symptoms may include a fast heart rate, sweating, and large pupils. High doses can result in very high blood pressure or body temperature. Effects begin within seconds to minutes of use and last between five and ninety minutes. Cocaine has a small number of accepted medical uses such as numbing and decreasing bleeding during nasal surgery.
Los Angeles, officially the City of Los Angeles and often known by its initials L.A., is the most populous city in California, the second most populous city in the United States, after New York City, and the third most populous city in North America. With an estimated population of four million, Los Angeles is the cultural, financial, and commercial center of Southern California. The city is known for its Mediterranean climate, ethnic diversity, Hollywood and the entertainment industry, and its sprawling metropolis. Los Angeles is the largest city on the West Coast of North America.
A screenplay writer, scriptwriter or scenarist, is a writer who practices the craft of screenwriting, writing screenplays on which mass media, such as films, television programs and video games, are based.
The book ends with Will lying in bed at night, trying to cry because he knows the therapeutic values of tears, but he is unable to. After all the anti-depressants he had helped make during his lifetime, he wonders if there is any way somebody can prescribe tears.
