Phenicarbazide

Phenicarbazide

Clinical data
Other names	1-Phenylsemicarbazide; Kryogenin
ATC code	none
Identifiers
IUPAC name 2-Phenylhydrazinecarboxamide
CAS Number	103-03-7  N
ChemSpider	54963  Y
UNII	1LR2578324
KEGG	C19498  N
CompTox Dashboard (EPA)	DTXSID9020245
ECHA InfoCard	100.002.794
Chemical and physical data
Formula	C7H9N3O
Molar mass	151.169 g·mol−1
InChI InChI=1S/C7H9N3O/c8-7(11)10-9-6-4-2-1-3-5-6/h1-5,9H,(H3,8,10,11) Y Key:AVKHCKXGKPAGEI-UHFFFAOYSA-N Y
NY  (what is this?)    (verify)

Phenicarbazide is a semicarbazide and an antipyretic substance. It is carcinogenic in mice. ^[1]

Preparation

Phenicarbazide can be obtained by mixing phenylhydrazine with acetic acid in aqueous solution with the addition of potassium cyanide. It is also obtained from the reaction of phenylhydrazine with urea. ^[2]

Properties

Phenicarbazide is a flammable, hard to ignite, crystalline, beige solid that is practically insoluble in water. It decomposes on heating. ^[3]

Uses

Phenicarbazide is an intermediate in the syntheses of a series of chemical compounds by cyclocondensation reactions. ^[4] It was investigated as an analgesic and antipyretic in the 1970s and was used in combination preparations.

References

1. "Phenicarbazide". International Agency for Research on Cancer (IARC) - Summaries & Evaluations. 25 March 1998.
2. Bruchhausen F, Ebel S, Hackenthal E, Holzgrabe U, Albinus M, Amschler G, Angerer E (1999). Hagers Handbuch der Pharmazeutischen Praxis : Stoffe L-Z Folgeband 5 (5. vollständig neubearbeitete Auflage ed.). Berlin, Heidelberg. p. 420. ISBN   978-3-642-58388-9. OCLC   913646782.
3. "Phenicarbazid". GESTIS-Stoffdatenbank. Retrieved 2022-10-18.
4. "1-Phenylsemicarbazide". Sigma-Aldrich.