Qasim Mehdi

Last updated
S. Qasim Mehdi
Born13 February 1941
Died28 September 2016 (aged 75)
NationalityPakistani
CitizenshipPakistan
Alma mater
Known for
Awards
Scientific career
Fields Molecular biology, Genetics
Institutions
Thesis Synthesis and Control of Bacterial Ribonucleic Acids  (1969)

S. Qasim Mehdi (or Syed Qasim Mehdi) was a renowned Pakistani molecular biologist [1] [2] [3] who worked in population genetics. He was a founding member of the Human Genome Diversity Project (HGDP) with prominent role in the initiation of this project at the Stanford University. [4]

Biography

Mehdi was born in Lucknow, India, where he completed his B.S. from the Lucknow University. He received his MS from MIT and then a D.Phil. (doctorate) degree from the Oxford University, where he had mentors like Nobel laureates Sir Hans Krebs and Rodney Porter. His doctoral education was followed by a series of fellowships at the Oxford and the Wellcome Trust, until appointed by the Stanford University as a research associate in 1976 and later a senior research fellow, affiliated with the Stanford University Departments of Chemistry and Radiology and Stanford Cancer Biology Research Labs. [3] He has been fellow of the Wellcome Trust (1972–1974) and the Biochemical Society, UK (1972–1997), other than holding numerous other honors, awards, and fellowships.

His last appointment was serving as the chairman of the Center for Human Genetics at the Sindh Institute of Urology and Transplantation, Karachi, Pakistan, as well as a distinguished visiting professor in the University of Karachi, Karachi Pakistan. [5] In past, he had served as a Distinguished National Professor, Higher Education Commission Pakistan, and director general of the Biomedical & Genetic Engineering Division, Islamabad, [2] at the Institute for Biotechnology & Genetic Engineering, University of Karachi, Pakistan. He was a recipient of the Government of Pakistan civil awards, Sitara-e-Imtiaz (1998) and Hilal-e-Imtiaz, the "Crescent of Distinction" (2003) conferred by the president of Pakistan.

He had been a member of the American Association for the Advancement of Science, the New York Academy of Sciences, Prime Ministers Cabinet Committee for the Evaluation of Research, Development in Science and Technology in Pakistan, Advanced Studies Board, HEJ Research Inst. of Chemistry, Karachi University, 1993-, The World Bank Committee for Higher Education in Pakistan, elected member, Scientific and Medical Advisory Board, the International Retinitis Pigmentosa Society (Retinitis Pigmentosa International) and The Foundation Fighting Blindness society, Washington DC (1993–present), Human Genome Organization (HUGO), London (UK), founding member, Human Genome Diversity Project (HGDP) USA. (1994–present), chairman, Southwest Asia Committee and Member International Executive Committee, HGDP and (1997–present), among a number of other professional bodies.

During his last years, he had been working on charting a direction for the future of biomedical research in Pakistan. [6]

Other than his role in HGDP, he is known for his groundbreaking work on the genetics of human populations, [2] especially on research work related to the human features of Light skin and Dark skin, where he and his team made important contributions (ref.: see Light skin and Dark skin pages citing his work). He has written over two hundred publications, including papers in Science, Nature Genetics and Genome Research. As per google scholar, his publications have accrued a total number of 7745 citations, his scholarly indices include an h-index of 38 and I10-index of 67. [7]

Mehdi died peacefully in Lahore on 28 September 2016 after a protracted illness. [8]

Fellowships

Fellow Wellcome Trust

Fellow Biochemical Society

Fellow Third World Academy of Sciences

Fellow Pakistan Academy of Sciences

Fellow Islamic Academy of Sciences

Fellow Chemical Society of Pakistan

Selected publications (highly-cited work)

Related Research Articles

<span class="mw-page-title-main">Rhodopsin</span> Light-sensitive receptor protein

Rhodopsin, also known as visual purple, is a protein encoded by the RHO gene and a G-protein-coupled receptor (GPCR). It is the opsin of the rod cells in the retina and a light-sensitive receptor protein that triggers visual phototransduction in rods. Rhodopsin mediates dim light vision and thus is extremely sensitive to light. When rhodopsin is exposed to light, it immediately photobleaches. In humans, it is regenerated fully in about 30 minutes, after which the rods are more sensitive. Defects in the rhodopsin gene cause eye diseases such as retinitis pigmentosa and congenital stationary night blindness.

<span class="mw-page-title-main">Retinitis pigmentosa</span> Gradual retinal degeneration leading to progressive sight loss

Retinitis pigmentosa (RP) is a genetic disorder of the eyes that causes loss of vision. Symptoms include trouble seeing at night and decreasing peripheral vision. As peripheral vision worsens, people may experience "tunnel vision". Complete blindness is uncommon. Onset of symptoms is generally gradual and often begins in childhood.

The Human Genome Diversity Project (HGDP) was started by Stanford University's Morrison Institute in 1990s along with collaboration of scientists around the world. It is the result of many years of work by Luigi Cavalli-Sforza, one of the most cited scientists in the world, who has published extensively in the use of genetics to understand human migration and evolution. The HGDP data sets have often been cited in papers on such topics as population genetics, anthropology, and heritable disease research.

<span class="mw-page-title-main">Walter Bodmer</span> German-born British human geneticist

Sir Walter Fred Bodmer is a German-born British human geneticist.

<span class="mw-page-title-main">Wellcome Sanger Institute</span> British genomics research institute

The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust.

<span class="mw-page-title-main">Burusho people</span> Ethnolinguistic group of Kashmir, South Asia

The Burusho, or Brusho, also known as the Hunzukuch, are an ethnolinguistic group indigenous to the Yasin, Hunza, Nagar, and other valleys of Gilgit–Baltistan in northern Pakistan, with a tiny minority of around 350 Burusho people residing in Jammu and Kashmir, India. Their language, Burushaski, has been classified as a language isolate.

<span class="mw-page-title-main">David Haussler</span> American bioinformatician

David Haussler is an American bioinformatician known for his work leading the team that assembled the first human genome sequence in the race to complete the Human Genome Project and subsequently for comparative genome analysis that deepens understanding the molecular function and evolution of the genome.

<span class="mw-page-title-main">Retinal G protein coupled receptor</span> Protein-coding gene in the species Homo sapiens

RPE-retinal G protein-coupled receptor also known as RGR-opsin is a protein that in humans is encoded by the RGR gene. RGR-opsin is a member of the rhodopsin-like receptor subfamily of GPCR. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. RGR-opsin comes in different isoforms produced by alternative splicing.

<span class="mw-page-title-main">Retinitis pigmentosa GTPase regulator</span> Protein-coding gene in the species Homo sapiens

X-linked retinitis pigmentosa GTPase regulator is a GTPase-binding protein that in humans is encoded by the RPGR gene. The gene is located on the X-chromosome and is commonly associated with X-linked retinitis pigmentosa (XLRP). In photoreceptor cells, RPGR is localized in the connecting cilium which connects the protein-synthesizing inner segment to the photosensitive outer segment and is involved in the modulation of cargo trafficked between the two segments.

<span class="mw-page-title-main">RPGRIP1</span> Protein-coding gene in the species Homo sapiens

X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 is a protein in the ciliary transition zone that in humans is encoded by the RPGRIP1 gene. RPGRIP1 is a multi-domain protein containing a coiled-coil domain at the N-terminus, two C2 domains and a C-terminal RPGR-interacting domain (RID). Defects in the gene result in the Leber congenital amaurosis (LCA) syndrome and in the eye disease glaucoma.

<span class="mw-page-title-main">ROM1</span> Protein-coding gene in the species Homo sapiens

Rod outer segment membrane protein 1 is a protein that in humans is encoded by the ROM1 gene.

Sir Michael Rudolf Stratton, is a British clinical scientist and the third director of the Wellcome Trust Sanger Institute. He currently heads the Cancer Genome Project and is a leader of the International Cancer Genome Consortium.

<span class="mw-page-title-main">Friedrich Miescher Institute for Biomedical Research</span> Facility in Basel, Switzerland

The Friedrich Miescher Institute for Biomedical Research (FMI) is a biomedical research institute founded in 1970. Based in Basel, Switzerland, the FMI is affiliated with the University of Basel and the Novartis Institutes for BioMedical Research (NIBR). It is named after Friedrich Miescher. As of 2021, the FMI has around 340 collaborators, of which 20 are research group leaders, over 80 are postdoctoral collaborators and over 80 are postgraduate students participating in the FMI International PhD Program. The FMI is directed by Dirk Schübeler.

<span class="mw-page-title-main">Wellcome Centre for Human Genetics</span>

The Wellcome Centre for Human Genetics is a human genetics research centre of the Nuffield Department of Medicine in the Medical Sciences Division, University of Oxford, funded by the Wellcome Trust among others.

Haplogroup Q-M120, also known as Q1a1a1, is a Y-DNA haplogroup. It is the only primary branch of haplogroup Q1a1a (F746/NWT01). The lineage is most common amongst modern populations in north-east Eurasia.

<span class="mw-page-title-main">Julie Segre</span> American geneticist

Julie Angela Segre is the Chief and Senior Investigator of the Translational and Functional Genomics Branch in the National Human Genome Research Institute at the National Institutes of Health. She was elected to the National Academy of Medicine in 2019, the American Academy of Arts and Sciences in 2020 and the National Academy of Sciences in 2022.

<span class="mw-page-title-main">ABHD12</span> Protein-coding gene in the species Homo sapiens

alpha/beta-Hydrolase domain containing 12 (ABHD12) is a serine hydrolase encoded by the ABHD12 gene that participates in the breakdown of the endocannabinoid neurotransmitter 2-arachidonylglycerol (2-AG) in the central nervous system. It is responsible for about 9% of brain 2-AG hydrolysis. Together, ABHD12 along with two other enzymes, monoacylglycerol lipase (MAGL) and ABHD6, control 99% of 2-AG hydrolysis in the brain. ABHD12 also serves as a lysophospholipase and metabolizes lysophosphatidylserine (LPS).

<span class="mw-page-title-main">Robert MacLaren</span> British ophthalmologist

Robert E. MacLaren FMedSci FRCOphth FRCS FACS VR is a British ophthalmologist who has led pioneering work in the treatment of blindness caused by diseases of the retina. He is Professor of Ophthalmology at the University of Oxford and Honorary Professor of Ophthalmology at the UCL Institute of Ophthalmology. He is a Consultant Ophthalmologist at the Oxford Eye Hospital. He is also an Honorary Consultant Vitreo-retinal Surgeon at the Moorfields Eye Hospital. MacLaren is an NIHR Senior Investigator, or lead researcher, for the speciality of Ophthalmology. In addition, he is a member of the research committee of Euretina: the European Society of Retina specialists, Fellow of Merton College, in Oxford and a Fellow of the Higher Education Academy.

The study of the genetics and archaeogenetics of the Gujarati people of India aims at uncovering these people's genetic history. According to the 1000 Genomes Project, "Gujarati" is a general term used to describe people who trace their ancestry to the region of Gujarat, located in the northwestern part of the Indian subcontinent, and who speak the Gujarati language, an Indo-European language. They have some genetic commonalities as well as differences with other ethnic groups of India.

<span class="mw-page-title-main">African Society of Human Genetics</span>

The African Society of Human Genetics (AfSHG) is a learned society and professional membership organization focused on the study of human genetics and genomics in Africans, and open to researchers who are interested in the subject. It has played a role in founding several national genetics societies, and is affiliated with the societies of Cameroon, the Democratic Republic of the Congo, Mali, Egypt, Rwanda, Senegal, South Africa, and Tanzania.

References

  1. "Dr Qasim Mehdi dies in Lahore". 2016-09-30.
  2. 1 2 3 "Prof. S. Qasim Mehdi". hstalks.com. Retrieved 7 June 2016.
  3. 1 2 "Prof. Syed Qasem Mehdi". ias-worldwide.org. Retrieved 7 June 2016.
  4. Xue, Yali; Zhang, Xuelong; Huang, Ni; Daly, Allan; Gillson, Christopher J.; MacArthur, Daniel G.; Yngvadottir, Bryndis; Nica, Alexandra C.; Woodwark, Cara; Chen, Yuan; Conrad, Donald F.; Ayub, Qasim; Mehdi, S. Qasim; Li, Pu; Tyler-Smith, Chris (1 November 2009). "Population Differentiation as an Indicator of Recent Positive Selection in Humans: An Empirical Evaluation". Genetics. 183 (3): 1065–1077. doi:10.1534/genetics.109.107722. PMC   2778960 . PMID   19737746 . Retrieved 7 June 2016.
  5. "Syed Qasim Mehdi - Info". researchgate.net. Retrieved 7 June 2016.
  6. "THE FUTURE OF MEDICINE AND BIOMEDICAL RESEARCH IN PAKISTAN: 1st Draft" (PDF). pc.gov.pk. Archived from the original (PDF) on 31 May 2016. Retrieved 7 June 2016.
  7. "Syed Qasim Mehdi - Google Scholar Citations". google.com. Retrieved 7 June 2016.
  8. "Distinguished scientist: Dr Qasim Mehdi passes away". 2016-09-29.