RNU2

RNU2-1
Identifiers
Aliases	RNU2-1 , RNU2, U2, RNA, U2 small nuclear 1
External IDs	OMIM: 180690 GeneCards: RNU2-1
RNA expression pattern
	Top expressed in
	sural nerve; ; Achilles tendon; ; corpus callosum; ; bone marrow; ; subcutaneous adipose tissue; ; monocyte; ; liver; ; blood; ; skin of abdomen; ; skeletal muscle tissue;
	n/a
	More reference expression data
	n/a
Orthologs
	6066
	n/a
	ENSG00000274585
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated April 12, 2024

RNA, U2 small nuclear, also known as RNU2, is a human gene.^[2]

Related Research Articles

<span class="mw-page-title-main">U4 spliceosomal RNA</span> Non-coding RNA component of the spliceosome

The U4 small nuclear Ribo-Nucleic Acid is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA). It forms a duplex with U6, and with each splicing round, it is displaced from the U6 snRNA in an ATP-dependent manner, allowing U6 to re-fold and create the active site for splicing catalysis. A recycling process involving protein Brr2 releases U4 from U6, while protein Prp24 re-anneals U4 and U6. The crystal structure of a 5′ stem-loop of U4 in complex with a binding protein has been solved.

<span class="mw-page-title-main">U7 small nuclear RNA</span>

The U7 small nuclear RNA is an RNA molecule and a component of the small nuclear ribonucleoprotein complex. The U7 snRNA is required for histone pre-mRNA processing.

POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.

Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.

2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene.

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.

Fragile X mental retardation syndrome-related protein 1 is a protein that in humans is encoded by the FXR1 gene.

Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.

Heterogeneous nuclear ribonucleoprotein H is a protein that in humans is encoded by the HNRNPH1 gene.

Pre-mRNA-processing factor 40 homolog A is a protein that in humans is encoded by the PRPF40A gene.

Splicing factor 3B subunit 1 is a protein that in humans is encoded by the SF3B1 gene.

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.

U5 small nuclear ribonucleoprotein 200 kDa helicase is an enzyme that in humans is encoded by the SNRNP200 gene.

Cleavage and polyadenylation specificity factor subunit 2 is a protein that in humans is encoded by the CPSF2 gene. This protein is a subunit of the cleavage and polyadenylation specificity factor (CPSF) complex which plays a key role in pre-mRNA 3' end processing and polyadenylation. The CPSF2 protein connects the two subunits of the complex, mCF and mPSF. Its structure contributes both to the stability of the subunits interaction and to the flexibility of the complex necessary for function. This protein has been identified as an essential subunit of the complex as certain mutations in the region inhibit CPSF complex formation.

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.

snRNA-activating protein complex subunit 1 is a protein that in humans is encoded by the SNAPC1 gene.

Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.

References

↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: RNU2 RNA, U2 small nuclear".

Hausner TP, Giglio LM, Weiner AM (1991). "Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles". Genes Dev. 4 (12A): 2146–56. doi: 10.1101/gad.4.12a.2146 . PMID 2176635.
Ares M, Mangin M, Weiner AM (1985). "Orientation-dependent transcriptional activator upstream of a human U2 snRNA gene". Mol. Cell. Biol. 5 (7): 1560–70. doi:10.1128/MCB.5.7.1560. PMC 367274 . PMID 2410771.
Htun H, Lund E, Westin G, et al. (1985). "Nuclease S1-sensitive sites in multigene families: human U2 small nuclear RNA genes". EMBO J. 4 (7): 1839–45. doi:10.1002/j.1460-2075.1985.tb03858.x. PMC 554425 . PMID 2411549.
Westin G, Lund E, Murphy JT, et al. (1985). "Human U2 and U1 RNA genes use similar transcription signals". EMBO J. 3 (13): 3295–301. doi:10.1002/j.1460-2075.1984.tb02293.x. PMC 557852 . PMID 6084596.
Van Arsdell SW, Weiner AM (1984). "Human genes for U2 small nuclear RNA are tandemly repeated". Mol. Cell. Biol. 4 (3): 492–9. doi:10.1128/MCB.4.3.492. PMC 368727 . PMID 6201719.
Hammarström K, Westin G, Bark C, et al. (1984). "Genes and pseudogenes for human U2 RNA. Implications for the mechanism of pseudogene formation". J. Mol. Biol. 179 (2): 157–69. doi:10.1016/0022-2836(84)90463-7. PMID 6209403.
Pavelitz T, Rusché L, Matera AG, et al. (1995). "Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus". EMBO J. 14 (1): 169–77. doi:10.1002/j.1460-2075.1995.tb06987.x. PMC 398064 . PMID 7828589.
Liao D, Pavelitz T, Kidd JR, et al. (1997). "Concerted evolution of the tandemly repeated genes encoding human U2 snRNA (the RNU2 locus) involves rapid intrachromosomal homogenization and rare interchromosomal gene conversion". EMBO J. 16 (3): 588–98. doi:10.1093/emboj/16.3.588. PMC 1169662 . PMID 9034341.
Liao D, Pavelitz T, Weiner AM (1998). "Characterization of a novel class of interspersed LTR elements in primate genomes: structure, genomic distribution, and evolution". J. Mol. Evol. 46 (6): 649–60. Bibcode:1998JMolE..46..649L. CiteSeerX 10.1.1.323.2259 . doi:10.1007/PL00006345. PMID 9608047. S2CID 2101182.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Jacobs EY, Ogiwara I, Weiner AM (2004). "Role of the C-terminal domain of RNA polymerase II in U2 snRNA transcription and 3' processing". Mol. Cell. Biol. 24 (2): 846–55. doi:10.1128/MCB.24.2.846-855.2004. PMC 343789 . PMID 14701755.
Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884 . PMID 15456888.

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[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-2] "Entrez Gene: RNU2 RNA, U2 small nuclear".

[1]

[2]

RNU2

Related Research Articles

References

Further reading