RNU4-1

RNU4-1
Identifiers
Aliases	RNU4-1 , RNU4A, RNU4B2, U4, U4BL, RNA, U4 small nuclear 1
External IDs	GeneCards: RNU4-1; OMA:RNU4-1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	120,293,237 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; blood; ; corpus callosum; ; kidney; ; Achilles tendon; ; monocyte; ; islet of Langerhans; ; liver; ; olfactory zone of nasal mucosa; ; lung;
	n/a
	More reference expression data
	n/a
Orthologs
	26835
	n/a
	ENSG00000200795
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated November 09, 2024

RNA, U4 small nuclear 1 is a protein that in humans is encoded by the RNU4-1 gene. ^[3]

Related Research Articles

A spliceosome is a large ribonucleoprotein (RNP) complex found primarily within the nucleus of eukaryotic cells. The spliceosome is assembled from small nuclear RNAs (snRNA) and numerous proteins. Small nuclear RNA (snRNA) molecules bind to specific proteins to form a small nuclear ribonucleoprotein complex, which in turn combines with other snRNPs to form a large ribonucleoprotein complex called a spliceosome. The spliceosome removes introns from a transcribed pre-mRNA, a type of primary transcript. This process is generally referred to as splicing. An analogy is a film editor, who selectively cuts out irrelevant or incorrect material from the initial film and sends the cleaned-up version to the director for the final cut.

<span class="mw-page-title-main">U4 spliceosomal RNA</span> Non-coding RNA component of the spliceosome

The U4 small nuclear Ribo-Nucleic Acid is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA). It forms a duplex with U6, and with each splicing round, it is displaced from the U6 snRNA in an ATP-dependent manner, allowing U6 to re-fold and create the active site for splicing catalysis. A recycling process involving protein Brr2 releases U4 from U6, while protein Prp24 re-anneals U4 and U6. The crystal structure of a 5′ stem-loop of U4 in complex with a binding protein has been solved.

rRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene.

Pre-mRNA-processing-splicing factor 8 is a protein that in humans is encoded by the PRPF8 gene.

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.

PRP31 pre-mRNA processing factor 31 homolog , also known as PRPF31, is a protein which in humans is encoded by the PRPF31 gene.

60S ribosomal protein L7a is a protein that in humans is encoded by the RPL7A gene.

U4/U6.U5 tri-snRNP-associated protein 1 is a protein that in humans is encoded by the SART1 gene. This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.

U4/U6 small nuclear ribonucleoprotein Prp3 is a protein that in humans is encoded by the PRPF3 gene.

U5 small nuclear ribonucleoprotein 200 kDa helicase is an enzyme that in humans is encoded by the SNRNP200 gene.

Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.

U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene.

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene. The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]

U6 snRNA-associated Sm-like protein LSm6 is a protein that in humans is encoded by the LSM6 gene.

Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.

Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.

RNA, U4atac small nuclear is a small nuclear RNA that in humans is encoded by the RNU4ATAC gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000200795 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: RNA, U4 small nuclear 1" . Retrieved 2018-09-03.

RNU4-1

Related Research Articles

References

Further reading