Ralph Isberg

Last updated
Ralph R. Isberg
Born(1955-01-03)January 3, 1955
Detroit, Michigan, U.S.
NationalityAmerican
Alma materOberlin College
Harvard University
Scientific career
FieldsMicrobiology
InstitutionsTufts University School of Medicine

Ralph R. Isberg (born January 3, 1955) is a professor at Tufts University School of Medicine [1] known for his contributions to understanding microbial pathogenesis. He is a member of the American National Academy of Sciences and was an investigator of the Howard Hughes Medical Institute [2] for 27 years. A microbiologist, Isberg has published over 185 peer-reviewed articles [3] and is or has been an editor of the Proceedings of the National Academy of Sciences, [4] PLoS Pathogens, and Journal of Experimental Medicine, among others. [3]

Contents

Early life

Isberg was born in Detroit, Michigan, on January 3, 1955.

Education and career

Isberg received an A.B. from Oberlin College (1977) and a Ph.D. from Harvard University (1984), performing his thesis on the mechanisms of Tn5 transposition in Michael Syvanen's laboratory. He performed his post-doctoral research in Stanley Falkow's lab at Stanford University (1984-1986), where he initiated studies of the entry of the bacterial pathogen Yersinia pseudotuberculosis into mammalian cells. He joined Tufts University's Sackler School of Graduate Biomedical Sciences in 1986 and is currently Professor of Molecular Biology & Microbiology there. [1] He is also the co-director of the Center for Enteric Disease in Engineered Tissues (CEDET) and Program Director of Molecular Basis of Microbial Pathogenesis.

Isberg has mentored over 20 Ph.D. students, and over 40 post-doctoral fellows.

Research

Isberg's research has mainly been in the field of microbial pathogenesis. [5] His lab focuses on the pathogenesis of Legionella pneumophila and Yersinia pseudotuberculosis , especially the ways these pathogens enter and regulate host mammalian cells. [6]

Honors and awards

Isberg has received many honors and awards, [3] including:

Personal life

Isberg is married to Carol Kumamoto, also a Professor at the Sackler School of Graduate Biomedical Sciences, and has two children, Max and Robyn. [3]

Isberg is known for constructing a hockey rink in his back yard each winter. [8]

Related Research Articles

<i>Yersinia pestis</i> Species of bacteria, cause of plague

Yersinia pestis is a gram-negative, non-motile, coccobacillus bacterium without spores that is related to both Yersinia pseudotuberculosis and Yersinia enterocolitica. It is a facultative anaerobic organism that can infect humans via the Oriental rat flea. It causes the disease plague, which caused the first plague pandemic and the Black Death, the deadliest pandemic in recorded history. Plague takes three main forms: pneumonic, septicemic, and bubonic. Yersinia pestis is a parasite of its host, the rat flea, which is also a parasite of rats, hence Y. pestis is a hyperparasite.

G. Balakrish Nair is an Indian microbiologist. At present, he is the Ag. Regional Adviser, Research Policy and Cooperation Unit, Department of Communicable Diseases, World Health Organization. Before joining WHO, he was the executive director of Translational Health Science and Technology Institute (THSTI), Faridabad, NCR, India. Before joining THSTI, he was working in NICED as the director. He has also served as the director of Laboratory Sciences Division at the International Center for Diarrhoeal Diseases Research,, Dhaka, Bangladesh.

<span class="mw-page-title-main">Stanley Falkow</span> American microbiologist

Stanley "Stan" Falkow was an American microbiologist and a professor of microbiology at Georgetown University, University of Washington, and Stanford University School of Medicine. Falkow is known as the father of the field of molecular microbial pathogenesis. He formulated molecular Koch's postulates, which have guided the study of the microbial determinants of infectious diseases since the late 1980s. Falkow spent over 50 years uncovering molecular mechanisms of how bacteria cause disease and how to disarm them. Falkow also was one of the first scientists to investigate antimicrobial resistance, and presented his research extensively to scientific, government, and lay audiences explaining the spread of resistance from one organism to another, now known as horizontal gene transfer, and the implications of this phenomenon on our ability to combat infections in the future.

<i>Yersinia pseudotuberculosis</i> Species of bacterium

Yersinia pseudotuberculosis is a Gram-negative bacterium that causes Far East scarlet-like fever in humans, who occasionally get infected zoonotically, most often through the food-borne route. Animals are also infected by Y. pseudotuberculosis. The bacterium is urease positive.

Thomas E. Shenk is the James A. Elkins Jr. Professor in the Life Sciences in the department of Molecular Biology at Princeton University. Although his publications have contributed to the fields of biochemistry, cell biology, genetics, genomics, microbiology and virology, his present research interest involves the cytomegalovirus. Aside from academic involvement, Dr. Shenk has sat on the board of directors of Merck & Co. and the Fox Chase Cancer Center.

<span class="mw-page-title-main">Philippe Sansonetti</span>

Philippe J. Sansonetti is a French microbiologist, professor at the Pasteur Institute and the Collège de France in Paris. He is the director of the Inserm Unit 786 and of the Institut Pasteur laboratory Pathogénie Microbienne Moléculaire.

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<span class="mw-page-title-main">David Relman</span> American microbiologist

David Arnold Relman is an American microbiologist and the Thomas C. and Joan M. Merigan Professor in Medicine, and in Microbiology & Immunology at the Stanford University School of Medicine. His research focuses on the human microbiome and microbial ecosystem—for which he was a pioneer in the use of modern molecular methods, as well as on pathogen discovery and the genomics of host response.

Daniel A. Portnoy is a microbiologist, the Edward E. Penhoet Distinguished Chair in Global Public Health and Infectious Diseases, and a Professor of Biochemistry, Biophysics and Structural Biology in the Department of Molecular and Cell Biology and in the Division of Microbiology in the Department of Plant and Microbial Biology at the University of California, Berkeley. He is one of the world's foremost experts on Listeria monocytogenes, the bacterium that causes the severe foodborne illness Listeriosis. He has made seminal contributions to multiple aspects of bacterial pathogenesis, cell biology, innate immunity, and cell mediated immunity using L. monocytogenes as a model system and has helped to push forward the use of attenuated L. monocytogenes as an immunotherapeutic tool in the treatment of cancer.

B. Brett Finlay, is a Canadian microbiologist well known for his contributions to understanding how microbes cause disease in people and developing new tools for fighting infections, as well as the role the microbiota plays in human health and disease. Science.ca describes him as one of the world's foremost experts on the molecular understanding of the ways bacteria infect their hosts. He also led the SARS Accelerated Vaccine Initiative (SAVI) and developed vaccines to SARS and a bovine vaccine to E. coli O157:H7. His current research interests focus on pathogenic E. coli and Salmonella pathogenicity, and the role of the microbiota in infections, asthma, and malnutrition. He is currently the UBC Peter Wall Distinguished Professor and a Professor in the Michael Smith Laboratories, Microbiology and Immunology, and Biochemistry and Molecular Biology, and Co-director and Senior Fellow for the CIFAR Humans and Microbes program. He is also co-author of the book Let Them Eat Dirt: Saving Your Child from an Oversanitized World and The Whole-Body Microbiome: How to Harness Microbes - Inside and Out - For Lifelong Health. Finlay is the author of over 500 publications in peer-reviewed journals and served as editor of several professional publications for many years.

Alejandro Aballay is an American biologist, currently Professor and Chair of the Department of Molecular Microbiology & Immunology at Oregon Health & Science University. Dr. Aballay was Professor and the Director of the Center for Host-Microbial Interactions at Duke University School of Medicine until 2017. In 2013, he was elected to the American Association for the Advancement of Science.

Howard C. Hang is an American chemist and professor in the Department of Immunology and Microbiology and Department of Chemistry at The Scripps Research Institute, California campus. He was previously Richard E. Salomon Family Associate Professor and the head of the Laboratory of Chemical Biology and Microbial Pathogenesis at the Rockefeller University in New York City. He won the Eli Lilly Award in Biological Chemistry in 2017.

Dipshikha Chakravortty is an Indian microbiologist, molecular pathologist and a professor at the department of Microbiology and Cell Biology at the Indian Institute of Science. Known for her studies on Salmonella and antibacterial resistance, Chakravortty is an elected fellow of the National Academy of Sciences, India, the Indian Academy of Sciences and the Indian National Science Academy. The Department of Biotechnology of the Government of India awarded her the National Bioscience Award for Career Development, one of the highest Indian science awards, for her contributions to biosciences, in 2010.

Christine Jacobs-Wagner is a microbial molecular biologist. She is the William H. Fleming, MD Professor of Molecular, Cellular, and Developmental Biology at Yale University and Professor of Microbial Pathogenesis, HHMI investigator, and Director of the Microbial Sciences Institute at Yale Medical School. Jacobs-Wagner's research has shown that bacterial cells have a great deal of substructure including analogs of microfilaments, and that proteins are directed by regulatory processes to locate to specific places within the bacterial cell. She was elected to the National Academy of Sciences in 2015 and has received a number of scientific awards.

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Carol Kumamoto is an American microbiologist who is Professor of Molecular Biology & Microbiology at Tufts University. She investigates the filamentous growth of Candida albicans, a fungal pathogen that causes several diseases. She is also interested in how C. albicans interacts with its host during colonisation and invasive diseases. She is a Fellow of the American Association for the Advancement of Science and the American Academy of Microbiology.

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