Reticulate acropigmentation of Kitamura

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Reticulate acropigmentation of Kitamura
Other namesRAK [1]
Specialty Dermatology
Symptoms Coloured freckle-like and slightly depressed flat spots arranged in a lace-like pattern [2]
Usual onsetTeenagers and early adulthood [2]
Differential diagnosis Dowling–Degos disease [2]
FrequencyRare [1]

Reticulate acropigmentation of Kitamura is a type of pigmentation disorder of the skin. [2] It presents with coloured freckle-like and slightly depressed flat spots arranged in a lace-like pattern on the backs of hands and feet. [2] It tends to occur in skin folds of teenagers and in early adulthood, and darkens over time. [2]

Contents

It is inherited in an autosomal-dominant fashion. [2]

The condition is rare. [1] It was first described in Japan, before recognising that is also occurs elsewhere. [2]

Genetics

This condition is associated with mutations in the a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) gene. This association was first shown in 2013.[ citation needed ]

See also

References

  1. 1 2 3 "Orphanet: Reticulate acropigmentation of Kitamura". www.orpha.net. Retrieved 23 April 2019.
  2. 1 2 3 4 5 6 7 8 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "36. Disturbances of pigmentation: Reticulate acropigmentation of Kitamura". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 867. ISBN   978-0-323-54753-6.


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