Robert Clarke (academic)

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  1. 1 2 "Biochemistry Molecular Biology & Biophysics".
  2. 1 2 "Robert Clarke, Ph.D., D.Sc. at University of Minnesota".
  3. ↑ "Robert Clarke at Google Scholar". scholar.google.com.
  4. ↑ "Robert Clarke at ORCID".
  5. ↑ Clarke, Robert; Tyson, John J.; Dixon, J. Michael (December 15, 2015). "Endocrine resistance in breast cancer – an overview and update". Molecular and Cellular Endocrinology. 418 (3): 220–234. doi:10.1016/j.mce.2015.09.035. PMC   4684757 . PMID   26455641.
  6. 1 2 "AAAS Announces Leading Scientists Elected as 2019 Fellows | American Association for the Advancement of Science". www.aaas.org.
  7. ↑ "Editorial Board | Clinical Cancer Research".
  8. ↑ "Editorial Board Endocrine-Related Cancer".
  9. ↑ "Editorial Board | Cancer Research". cancerres.aacrjournals.org.
  10. ↑ "BGRO and Other Sectors of Georgetown University Medical Center". Office of Faculty and Academic Affairs.
  11. ↑ "Masonic Cancer Center Leadership".
  12. ↑ Clarke, Robert; Brünner, Nils; Katzenellenbogen, Benita, S.; Thompson, Eric, W.; Normal, Mary Jane; Koppi, Caroline; Paik, Soonmyoung; Lippman, Marc, E.; Dickson, Robert, B. (1989). "Progression of human breast cancer cells from hormone-dependent to hormone-independent growth both in vitro and in vivo". Proceedings of the National Academy of Science USA. 86: 3649-3653. doi:10.1073/pnas.86.10.3649. PMID   2726742.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  13. ↑ Brünner, N.; Boulay, V.; Fojo, A.; Freter, C. E.; Lippman, M. E.; Clarke, R. (January 15, 1993). "Acquisition of hormone-independent growth in MCF-7 cells is accompanied by increased expression of estrogen-regulated genes but without detectable DNA amplifications". Cancer Research. 53 (2): 283–290. PMID   8380254 – via PubMed.
  14. ↑ Brünner, N.; Frandsen, T. L.; Holst-Hansen, C.; Bei, M.; Thompson, E. W.; Wakeling, A. E.; Lippman, M. E.; Clarke, R. (July 15, 1993). "MCF7/LCC2: a 4-hydroxytamoxifen resistant human breast cancer variant that retains sensitivity to the steroidal antiestrogen ICI 182,780". Cancer Research. 53 (14): 3229–3232. PMID   8324732 – via PubMed.
  15. ↑ Brünner, N.; Boysen, B.; Jirus, S.; Skaar, T. C.; Holst-Hansen, C.; Lippman, J.; Frandsen, T.; Spang-Thomsen, M.; Fuqua, S. A.; Clarke, R. (August 15, 1997). "MCF7/LCC9: an antiestrogen-resistant MCF-7 variant in which acquired resistance to the steroidal antiestrogen ICI 182,780 confers an early cross-resistance to the nonsteroidal antiestrogen tamoxifen". Cancer Research. 57 (16): 3486–3493. PMID   9270017 – via PubMed.
  16. ↑ Clarke, Robert; Tyson, John J.; Tan, Ming; Baumann, William T.; Jin, Lu; Xuan, Jianghua; Wang, Yue (2019). "Systems biology: perspectives on multiscale modeling in research on endocrine-related cancers". Endocr Relat Cancer. 26 (6): R345 –R368. doi:10.1530/erc-18-0309. PMC   7045974 . PMID   30965282.
  17. 1 2 Tyson, John J.; Baumann, William T.; Chen, Chun; Verdugo, Anael; Tavassoly, Iman; Wang, Yue; Weiner, Louis M.; Clarke, Robert (July 10, 2011). "Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells". Nature Reviews Cancer. 11 (7): 523–532. doi:10.1038/nrc3081. PMC   3294292 . PMID   21677677.
  18. 1 2 3 Clarke, Robert; Cook, Katherine L.; Hu, Rong; Facey, Caroline O. B.; Tavassoly, Iman; Schwartz, Jessica L.; Baumann, William T.; Tyson, John J.; Xuan, Jianhua; Wang, Yue; Wärri, Anni; Shajahan, Ayesha N. (March 15, 2012). "Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate". Cancer Research. 72 (6): 1321–1331. doi:10.1158/0008-5472.CAN-11-3213. PMC   3313080 . PMID   22422988.
  19. 1 2 Wang, Li Hua; Yang, Xiao Yi; Zhang, Xiaohu; An, Ping; Kim, Han-Jong; Huang, Jiaqiang; Clarke, Robert; Osborne, C. Kent; Inman, John K.; Appella, Ettore; Farrar, William L. (December 10, 2006). "Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer". Cancer Cell. 10 (6): 487–499. doi: 10.1016/j.ccr.2006.09.015 . PMID   17157789.
  20. ↑ Bouker, Kerrie B.; Skaar, Todd C.; Riggins, Rebecca B.; Harburger, David S.; Fernandez, David R.; Zwart, Alan; Wang, Antai; Clarke, Robert (September 10, 2005). "Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis". Carcinogenesis. 26 (9): 1527–1535. doi: 10.1093/carcin/bgi113 . PMID   15878912.
  21. ↑ Bouker, Kerrie B.; Skaar, Todd C.; Harburger, David S.; Riggins, Rebecca B.; Fernandez, David R.; Zwart, Alan; Clarke, Robert (May 10, 2007). "The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines". Cancer Genetics and Cytogenetics. 175 (1): 61–64. doi:10.1016/j.cancergencyto.2006.12.008. PMID   17498560 – via PubMed.
  22. ↑ Clarke, Robert; Ressom, Habtom W.; Wang, Antai; Xuan, Jianhua; Liu, Minetta C.; Gehan, Edmund A.; Wang, Yue (January 10, 2008). "The properties of high-dimensional data spaces: implications for exploring gene and protein expression data". Nature Reviews Cancer. 8 (1): 37–49. doi:10.1038/nrc2294. PMC   2238676 . PMID   18097463.
  23. 1 2 Fan, Ming; Xia, Pingping; Clarke, Robert; Wang, Yue; Li, Lihua (September 25, 2020). "Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer". Nature Communications. 11 (1): 4861. Bibcode:2020NatCo..11.4861F. doi:10.1038/s41467-020-18703-2. hdl: 10919/102232 . PMC   7519071 . PMID   32978398.
  24. ↑ Hilakivi-Clarke, Leena; Clarke, Robert; Onojafe, Ighovie; Raygada, Margarita; Cho, Elizabeth; Lippman, Marc (1997). "A maternal diet high in n-6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring". Proceedings of the National Academy of Science USA. 94 (17): 9372–9377. Bibcode:1997PNAS...94.9372H. doi: 10.1073/pnas.94.17.9372 . PMC   23197 . PMID   9256489.
  25. ↑ Johnson, Michael, D.; Kenny, Nicholas; Stoica, Adriana; Hilakivi-Clarke, Leena, A.; Singh, Baljit; Chepko, Gloria; Clarke, Robert; Sholler, Peter, F.; Lirio, Apolonio, A.; Foss, Colby; Reiter, Ronald; Trock, Bruce; Paik, Soonmyoung; Martin, Mary Beth (2003). "Cadmium mimics the effects of estrogen in vivo in the uterus and mammary gland". Nature Medicine. 9 (8): 1081–1084. doi:10.1038/nm902. PMID   12858169.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  26. ↑ Trock, Bruce; Hilakivi-Clarke, Leena A.; Clarke, Robert (2006). "Meta-analysis of soy intake and breast cancer risk". Journal of the National Cancer Institute. 98 (7): 459–471. doi:10.1093/jnci/djj102. PMID   16595782.
  27. ↑ Clarke, R.; van den Berg, H. W.; Murphy, R. F. (November 7, 1990). "Reduction of the membrane fluidity of human breast cancer cells by tamoxifen and 17 beta-estradiol". Journal of the National Cancer Institute. 82 (21): 1702–1705. doi:10.1093/jnci/82.21.1702. PMID   2231758 – via PubMed.
  28. ↑ Clarke, R.; Currier, S.; Kaplan, O.; Lovelace, E.; Boulay, V.; Gottesman, M. M.; Dickson, R. B. (October 7, 1992). "Effect of P-glycoprotein expression on sensitivity to hormones in MCF-7 human breast cancer cells". Journal of the National Cancer Institute. 84 (19): 1506–1512. doi:10.1093/jnci/84.19.1506. PMID   1359153 – via PubMed.
  29. ↑ Trock, B. J.; Leonessa, F.; Clarke, R. (July 2, 1997). "Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance". Journal of the National Cancer Institute. 89 (13): 917–931. doi:10.1093/jnci/89.13.917. PMID   9214671.
  30. ↑ Twentyman, Peter R. (1992). "MDRl (P-glycoprotein) gene expression—implications for resistance modifier trials". Journal of the National Cancer Institute. 84 (19): 1458–1460. doi:10.1093/jnci/84.19.1458. PMID   1359150.
  31. ↑ Shajahan, Ayesha N.; Wang, Aifen; Decker, Markus; Minshall, Richard D.; Liu, Minetta C.; Clarke, Robert (February 23, 2007). "Caveolin-1 Tyrosine phosphorylation enhances Paclitaxel-mediated cytotoxicity". Journal of Biological Chemistry. 282 (8): 5934–5943. doi: 10.1074/jbc.M608857200 . PMID   17190831.
  32. ↑ Shajahan, Ayesha N.; Dobbin, Zachary C.; Hickman, F. Edward; Dakshanamurthy, Sivanesan; Clarke, Robert (May 18, 2012). "Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to Paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK)". The Journal of Biological Chemistry. 287 (21): 17682–17692. doi: 10.1074/jbc.M111.304022 . PMC   3366801 . PMID   22433870.
  33. 1 2 Gu, Zhiping; Lee, Richard; Skaar, Todd C.; Bouker, Kerrie.B.; Welch, James N.; Lu, Jin; Wang, Ayiy; Zhu, Yuelin; Davis, N.; Leonessa, F.; Brünner, Nils; Wang, Yue; Clarke, Robert (June 15, 2002). "Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780)". Cancer Research. 62 (12): 3428–3437. PMID   12067985.
  34. ↑ Wärri, Anni; Cook, Katherine L.; Hu, Rong; Jin, Lu; Zwart, Alan; Soto-Pantoja, David R.; Liu, Jie; Finkel, Toren; Clarke, Robert (October 15, 2018). "Autophagy and unfolded protein response (UPR) regulate mammary gland involution by restraining apoptosis-driven irreversible changes". Cell Death Discovery. 4 (1): 40. doi:10.1038/s41420-018-0105-y. PMC   6186758 . PMID   30345078.
  35. ↑ Cook, Katherine L.; Shajahan, Ayesha N.; Wärri, Anni; Jin, Lu; Hilakivi-Clarke, Leena A.; Clarke, Robert (July 1, 2012). "Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness". Cancer Research. 72 (13): 3337–3349. doi:10.1158/0008-5472.CAN-12-0269. PMC   3576872 . PMID   22752300.
  36. ↑ Cook, Katherine L.; Soto-Pantoja, David R.; Clarke, Pamela A. G.; Cruz, M. Idalia; Zwart, Alan; Wärri, Anni; Hilakivi-Clarke, Leena; Roberts, David D.; Clarke, Robert (October 1, 2016). "Endoplasmic reticulum stress protein GRP78 modulates lipid metabolism to control drug sensitivity and antitumor immunity in breast cancer". Cancer Research. 76 (19): 5657–5670. doi:10.1158/0008-5472.CAN-15-2616. PMC   5117832 . PMID   27698188.
  37. ↑ Hilakivi-Clarke, Leena; Wärri, Anni; Bouker, Kerrie B; Zhang, Xiyuan; Cook, Katherine L; Jin, Lu; Zwart, Alan; Nguyen, Nguyen; Hu, Rong; Cruz, M Idalia; de Assis, Sonia; Wang, Xiao; Xuan, Jason; Wang, Yue; Wehrenberg, Bryan; Clarke, Robert (September 8, 2016). "Effects of In Utero Exposure to ethinyl estradiol on Tamoxifen resistance and breast cancer recurrence in a preclinical model". Journal of the National Cancer Institute. 109 (1): djw188. doi:10.1093/jnci/djw188. PMC   6255695 . PMID   27609189.
  38. ↑ Chen, Chun; Baumann, William T.; Xing, Jianhua; Clarke, Robert; Tyson, John J (2014). "Mathematical models of the transitions between endocrine therapy responsive and resistant states in breast cancer". Journal of the Royal Society Interface. 11 (96). doi:10.1098/rsif.2014.0206. PMC   4032535 . PMID   24806707.
  39. ↑ Clarke, Robert; Kraikivski, Pavel; Jones, Brandon C.; Sevigny, Catherine M.; Sengupta, Surojeet; Wang, Yue (September 10, 2020). "A systems biology approach to discovering pathway signaling dysregulation in metastasis". Cancer and Metastasis Reviews. 39 (3): 903–918. doi:10.1007/s10555-020-09921-7. PMC   7487029 . PMID   32776157.
  40. ↑ "2012-2013". www.sigmaxi.org.
Robert Clarke
Robert Clarke Academic.jpg
NationalityNorthern Irish
Occupation(s) Cancer researcher and academic administrator
AwardsFellow, American Association for the Advancement of Science (USA)
Fellow, Royal Society of Chemistry (UK)
Fellow, Royal Society of Biology (UK)
Fellow, Royal Society of Medicine (UK)
Academic background
EducationBSc Biological Sciences
MSc Biochemistry
PhD Biochemistry
Alma mater Ulster University
Queen's University Belfast
International
National
Academics
Other
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