Rosemary Redfield

Rosie Redfield
Born	Rosemary Jeanne Redfield
Alma mater	Monash University (BSc) McMaster University (MSc) Stanford University (PhD)
Awards	Nature's 10 (2011) [1]
Scientific career
Fields	Microbiology Genetics DNA Evolution [2]
Institutions	University of British Columbia Harvard University Johns Hopkins School of Medicine
Thesis	Generation of cryptic lambda prophages in Escherichia coli K-12  (1987)
Doctoral advisor	Allan M. Campbell
Website	rrresearch.fieldofscience.com

Rosemary Jeanne Redfield is a microbiologist associated with the University of British Columbia ^[2] where she worked as a faculty member in the Department of Zoology from 1993 until retiring in 2021. ^{[3] [4]}

Education

Redfield completed her undergraduate degree in biochemistry at Monash University. ^[5] She continued her education at McMaster University where she completed her MSc in 1980. Her thesis titled, "Methylation and chromatin conformation of adenovirus type 12 DNA sequences in transformed cells," dealt with the chromatin structure and SDNA methylation. ^[6] Redfield received her PhD in Biological Sciences from Stanford University under Allan M. Campbell.

Research and career

Redfield completed postdoctoral work at Harvard University with Richard Charles Lewontin and Johns Hopkins School of Medicine with Hamilton O. Smith, an American microbiologist and 1978 Nobel Laureate. ^[7] She played an early role in the refutation of the GFAJ-1 "arsenic life" results of Felisa Wolfe-Simon. ^{[8] [9] [10]} She joined University of British Colombia as a faculty member in 1993. ^[11] Rosie's primary research focus has been on the evolution and molecular biology of natural competence in bacteria, or the process through which bacteria take up DNA from their environment. ^[11] Throughout her career, Redfield championed alternative hypotheses and was not afraid to question generalized assumptions in her field. She notably critiqued a NASA-funded research study by exposing egregious experimental and technical flaws in the research paper. ^[11] She strongly believes in openness of research and she utilizes her blog as living lab notebook that is open to the public. ^[11] She retired in 2021. ^[11]

Select publications

• Boulton, Alan; Myers, Richard S.; Redfield, Rosemary J. (1997-07-22). "The hotspot conversion paradox and the evolution of meiotic recombination". Proceedings of the National Academy of Sciences. 94 (15): 8058–8063. Bibcode:1997PNAS...94.8058B. doi: 10.1073/pnas.94.15.8058 . ISSN   0027-8424. PMC   21556 . PMID   9223314.
• Redfield, Rosemary J. (2001). "Do bacteria have sex?". Nature Reviews Genetics. 2 (8): 634–639. doi:10.1038/35084593. ISSN   1471-0064. PMID   11483988. S2CID   5465846.
• Redfield, R (2002-08-01). "Is quorum sensing a side effect of diffusion sensing?". Trends in Microbiology. 10 (8): 365–370. doi:10.1016/s0966-842x(02)02400-9. ISSN   0966-842X. PMID   12160634.
• Redfield, Rosemary J.; Cameron, Andrew D. S.; Qian, Qing; Hinds, J.; Ali, Tahir R.; Kroll, J. Simon; Langford, Paul R. (2005-04-08). "A Novel CRP-dependent Regulon Controls Expression of Competence Genes in Haemophilus influenzae". Journal of Molecular Biology. 347 (4): 735–747. doi:10.1016/j.jmb.2005.01.012. ISSN   0022-2836. PMID   15769466.

Awards

• CIHR Grant (1999) - Regulation of competence in haemophilus influenzae ^[12]
• CIHR Grant (2012) - Regulation of CRP-S promoters in H. Influenzae and E. Coli ^[12]
• Nominated by Nature as one of Nature's 10 people who mattered in 2011. ^[1]

References

1. Butler, Declan; Callaway, Ewen; Check Hayden, Erika; Cyranoski, David; Hand, Eric; Nosengo, Nicola; Samuel Reich, Eugenie; Tollefson, Jeff; Yahia, Mohammed (2011). "365 days: Nature's 10". Nature. 480 (7378): 437–445. Bibcode:2011Natur.480..437B. doi: 10.1038/480437a . ISSN   0028-0836. PMID   22193082.
2. Rosemary Redfield publications indexed by Google Scholar
3. "Coursera - Free Online Courses From Top Universities". Coursera. Retrieved 2016-09-21.
4. ""Dr. Rosemary (Rosie) Redfield Retirement"" . Retrieved 2022-07-13.
5. "Bios | Cell Decision Making". physicsoflivingsystems.org. Retrieved 2016-09-22.
6. Redfield, Rosemary J. (1980). Methylation and chromatin conformation of adenovirus type 12 DNA sequences in transformed cells (Order No. MK50873). McMaster University – via ProQuest Dissertations & Theses Global.
7. "Looking to our leaders: An interview with Rosie Redfield". 2011-01-23. Retrieved 2016-09-26.
8. Reaves, Marshall Louis; Sinha, Sunita; Rabinowitz, Joshua D.; Kruglyak, Leonid; Redfield, Rosemary J. (2012-07-27). "Absence of Detectable Arsenate in DNA from Arsenate-Grown GFAJ-1 Cells". Science. 337 (6093): 470–473. arXiv: 1201.6643 . Bibcode:2012Sci...337..470R. doi:10.1126/science.1219861. ISSN   0036-8075. PMC   3845625 . PMID   22773140.
9. Zimmer, Carl (2010-12-07). ""This Paper Should Not Have Been Published": Scientists see fatal flaws in the NASA study of arsenic-based life". Slate . ISSN   1091-2339 . Retrieved 2017-12-31.
10. Yong, Ed (2010-12-10). "Arsenic bacteria - a post-mortem, a review, and some navel-gazing". Not Exactly Rocket Science. Discover Magazine . Retrieved 2017-12-31.
11. ""Dr. Rosemary (Rosie) Redfield Retirement"" . Retrieved 2022-07-13.
12. "Canadian Research Information System" . Retrieved 2017-12-31.

External links

• Rosemary Redfield publications indexed by Google Scholar