RsaOG

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rsaOG RNA
Rsaog structure.pdf
The consensus secondary structure of RsaOG showing its pseudoknot, created in Varna. [1] Boundaries were determined by RACE mapping in Staphylococcus aureus N315 . [2]
Identifiers
SymbolRsaOG
Rfam RF01775
Other data
RNA typesRNA
Domain(s) Staphylococcus
PDB structures PDBe

RsaOG (an acronym for RNA S. aureus Orsay G) [2] is a non-coding RNA that was discovered in the pathogenic bacteria Staphylococcus aureus N315 using a large scale computational screening based on phylogenetic profiling. [3] It was first identified, but not named, in 2005. [4] RsaOG has since been identified in other strains of Staphylococcus aureus under the name of RsaI, [5] it has also been discovered in other members of the Staphylococcus genus (such as Staphylococcus carnosus ) but in no other bacteria. [2]

Contents

The RsaOG gene is conserved in all Staphylococcaceae sequenced genomes, its secondary structure contains two highly conserved unpaired sequences which have the ability to form a pseudoknot. [2] Northern blot experiments show that RsaOG is expressed in several S. aureus strains. [3] [5] Mapping of RsaOG ends indicates a size of 146 nucleotides in S. aureus. [5] RsaOG ncRNA is thought to have trans-acting regulatory functions, possibly on fine tuning toxin production or aiding with invasion. [2]

See also

References

  1. ↑ Darty K, Denise A, Ponty Y (August 2009). "VARNA: Interactive drawing and editing of the RNA secondary structure". Bioinformatics. 25 (15): 1974–1975. doi:10.1093/bioinformatics/btp250. PMC   2712331 . PMID   19398448.
  2. 1 2 3 4 5 Marchais A, Bohn C, Bouloc P, Gautheret D (March 2010). "RsaOG, a new staphylococcal family of highly transcribed non-coding RNA" . RNA Biol. 7 (2): 116–119. doi: 10.4161/rna.7.2.10925 . PMID   20200491 . Retrieved 2010-07-12.
  3. 1 2 Marchais A, Naville M, Bohn C, Bouloc P, Gautheret D (June 2009). "Single-pass classification of all noncoding sequences in a bacterial genome using phylogenetic profiles". Genome Res. 19 (6): 1084–1092. doi:10.1101/gr.089714.108. PMC   2694484 . PMID   19237465.
  4. ↑ Pichon C, Felden B (October 2005). "Small RNA genes expressed from Staphylococcus aureus genomic and pathogenicity islands with specific expression among pathogenic strains". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14249–14254. doi: 10.1073/pnas.0503838102 . PMC   1242290 . PMID   16183745.
  5. 1 2 3 Geissmann T, Chevalier C, Cros MJ, et al. (November 2009). "A search for small noncoding RNAs in Staphylococcus aureus reveals a conserved sequence motif for regulation". Nucleic Acids Res. 37 (21): 7239–7257. doi:10.1093/nar/gkp668. PMC   2790875 . PMID   19786493.
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