Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast.
A syrt is a kind of an elevated landform in Russia and Central Asia.
Yeruslan is a river Saratov Oblast and Volgograd Oblast, Russia, a left tributary of the Volga River. It is 278 km long, origins at the south-western slope of the Obshchy Syrt and flows to the Yeruslan Cove of the Volgograd Reservoir. Yeruslan has the left inflow Solyonaya Kuba River. Former left tributary Torgun River currently flows to the Yeruslan Cove. The town of Krasny Kut is located alongside the Yeruslan.
Pleasant Plains is an elevated Staten Island Railway station in the neighborhood of Pleasant Plains, Staten Island, New York.
Oakwood Heights is a Staten Island Railway station in the neighborhood of Oakwood, Staten Island, New York.
Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene.
NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. SIRT2 is an NAD+ -dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context. The natural polyphenol resveratrol is known to exert opposite actions on neural cells according to their normal or cancerous status. Similar to other sirtuin family members, SIRT2 displays a ubiquitous distribution. SIRT2 is expressed in a wide range of tissues and organs and has been detected particularly in metabolically relevant tissues, including the brain, muscle, liver, testes, pancreas, kidney, and adipose tissue of mice. Of note, SIRT2 expression is much higher in the brain than all other organs studied, particularly in the cortex, striatum, hippocampus, and spinal cord.
NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin 3 ]. SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. SIRT3 exhibits NAD+-dependent deacetylase activity.
Sirtuin 6 is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. SIRT6 functions in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation.
The Mayer Bachmann Brewery (1851–1881) was the largest of a half-dozen breweries on Staten Island, New York, before its destruction by fire. After rebuilding, it operated as the Bachmann Brewery and then the Bachmann Bechtel Brewery until 1919.
Obshchy Syrt is a highland ridge, or plateau (syrt), in the European part of Russia. It starts north of Orenburg as a branch of the Ural Mountains and runs in a southwesterly direction to the east bank of the Volga River.
Sırt Çiçi is a village in the Quba Rayon of Azerbaijan. The village forms part of the municipality of Səbətlər.
Wentworth Avenue was a station on the demolished South Beach Branch of the Staten Island Railway. It had one side platform served by one track and was located at Oceanside Avenue and Wentworth Avenue.
Belair Road is a demolished station on the abandoned South Beach Branch of the Staten Island Railway. It had two side platforms and two tracks, and was located at Vermont Avenue, between Belair Road & St. Johns Avenue. This station served the US Quarantine station, which was one block to the east.
Cedar Avenue was a station on the demolished South Beach Branch of the Staten Island Railway. It had two tracks and two side platforms and was located at Cedar Avenue and Railroad Avenue.
Arrochar was a station on the demolished South Beach Branch of the Staten Island Railway. It had two side platforms and two tracks and was located at Major Avenue. The station was able to platform two train cars.
Fort Wadsworth was a station on the demolished South Beach Branch of the Staten Island Railway, near the historic Fort Wadsworth. It had two side platforms and two tracks, and was located at Fingerboard Road.
Rosebank
South Beach was a station on the demolished South Beach Branch of the Staten Island Railway. It had two tracks and two side platforms, and was located at Sand Lane and Oceanside Avenue.
The Staten Island Railway (SIR) is the only rapid transit line in the New York City borough of Staten Island and is operated by the Staten Island Rapid Transit Operating Authority, a unit of the Metropolitan Transportation Authority. The railway is considered a standard railroad line, but only the western portion of the North Shore Branch, which is disconnected from the rest of the SIR, is used by freight and is connected to the national railway system.
