SEDLP

TRAPPC2B
Identifiers
Aliases	TRAPPC2B , MIP-2A, SEDLP, SEDLP1, TRAPPC2P1, trafficking protein particle complex 2B, trafficking protein particle complex subunit 2B
External IDs	GeneCards: TRAPPC2B; OMA:TRAPPC2B - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.43 Start 57,363,551 bp [1] End 57,365,405 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh left adrenal cortex left testis testicle right adrenal gland right testis gonad right adrenal cortex islet of Langerhans n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 10597 n/a Ensembl ENSG00000256060 n/a UniProt n a n/a RefSeq (mRNA) NM_001355204 NM_015890 n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 19: 57.36 – 57.37 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Trafficking protein particle complex subunit 2 is a protein that in humans is encoded by the TRAPPC2P1 gene. ^[3]

This gene has been described as a transcribed retropseudogene (or retro-xaptonuon) based on its structure which lacks most of the introns of SEDL and the detection of transcripts from this locus. Most retropseudogenes are thought to not express protein products. A protein product could potentially be encoded by this retropseudogene that would be identical to the protein product of the SEDL gene. However, it remains unclear whether this gene encodes a protein product or is a transcribed retropseudogene. ^[3]

References

1. GRCh38: Ensembl release 89: ENSG00000256060 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: SEDLP spondyloepiphyseal dysplasia, late, pseudogene".

Further reading

• Sacher M (2003). "Membrane traffic fuses with cartilage development". FEBS Lett. 550 (1–3): 1–4. Bibcode:2003FEBSL.550....1S. doi:10.1016/S0014-5793(03)00854-8. PMID   12935876. S2CID   7388750.
• Gécz J, Hillman MA, Gedeon AK, et al. (2001). "Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda". Genomics. 69 (2): 242–51. doi:10.1006/geno.2000.6326. PMID   11031107.
• Ghosh AK, Majumder M, Steele R, et al. (2001). "A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1". Mol. Cell. Biol. 21 (2): 655–62. doi:10.1128/MCB.21.2.655-662.2001. PMC   86643 . PMID   11134351.
• Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID   11181995.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ghosh AK, Steele R, Ray RB (2003). "Modulation of human luteinizing hormone beta gene transcription by MIP-2A". J. Biol. Chem. 278 (26): 24033–8. doi: 10.1074/jbc.M211982200 . PMID   12700240.
• Savarirayan R, Thompson E, Gécz J (2004). "Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400)". Eur. J. Hum. Genet. 11 (9): 639–42. doi: 10.1038/sj.ejhg.5201025 . PMID   12939648.
• Gécz J, Shaw MA, Bellon JR, de Barros Lopes M (2004). "Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not". Gene. 320: 137–44. doi:10.1016/S0378-1119(03)00819-9. PMID   14597397.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.