SLC25A51

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Solute carrier family 25 member 51, also known as SLC25A51 and MCART1, is a protein which in humans is encoded by the SLC25A51 gene. This gene encodes a mitochondrial NAD+ transporter [1] and is a member of the mitochondrial carrier family of solute carrier proteins.

Contents

Structure

The SLC25A51 gene is located on the p arm of chromosome 9 in position 13.2 and spans 24,954 base pairs. [2] The gene produces a 33.7 kDa protein composed of 297 amino acids. [3] This gene has 6 exons and encodes a multi-pass integral membrane protein localized to the mitochondrial inner membrane. [2] [3]

Function

The product of this gene (MCART1) is essential for the import of NAD+ into the mitochondria. [1] [4] [5]

Clinical significance

Diseases associated with this gene include urea cycle disorders. [6]

See also

References

  1. 1 2 Girardi, Enrico; Agrimi, Gennaro; Goldmann, Ulrich; Fiume, Giuseppe; Lindinger, Sabrina; Sedlyarov, Vitaly; Srndic, Ismet; Gürtl, Bettina; Agerer, Benedikt; Kartnig, Felix; Scarcia, Pasquale; Di Noia, Maria Antonietta; Liñeiro, Eva; Rebsamen, Manuele; Wiedmer, Tabea (2020-12-01). "Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import". Nature Communications. 11 (1): 6145. Bibcode:2020NatCo..11.6145G. doi:10.1038/s41467-020-19871-x. ISSN   2041-1723. PMC   7708531 . PMID   33262325.
  2. 1 2 "SLC25A51 solute carrier family 25 member 51 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2025-09-09.
  3. 1 2 "UniProt". UniProt. Retrieved 2025-09-09.
  4. ↑ Kory, Nora; uit de Bos, Jelmi; van der Rijt, Sanne; Jankovic, Nevena; Güra, Miriam; Arp, Nicholas; Pena, Izabella A.; Prakash, Gyan; Chan, Sze Ham; Kunchok, Tenzin; Lewis, Caroline A.; Sabatini, David M. (2020-10-21). "MCART1/SLC25A51 is required for mitochondrial NAD transport". Science Advances. 6 (43) eabe5310. Bibcode:2020SciA....6.5310K. doi:10.1126/sciadv.abe5310. PMC   7577609 . PMID   33087354.
  5. ↑ Luongo, Timothy S.; Eller, Jared M.; Lu, Mu-Jie; Niere, Marc; Raith, Fabio; Perry, Caroline; Bornstein, Marc R.; Oliphint, Paul; Wang, Lin; McReynolds, Melanie R.; Migaud, Marie E.; Rabinowitz, Joshua D.; Johnson, F. Brad; Johnsson, Kai; Ziegler, Mathias (December 2020). "SLC25A51 is a mammalian mitochondrial NAD+ transporter". Nature. 588 (7836): 174–179. doi:10.1038/s41586-020-2741-7. ISSN   1476-4687. PMC   7718333 . PMID   32906142.
  6. ↑ "DISEASES - SLC25A51". diseases.jensenlab.org. Retrieved 2025-09-09.
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