SPANXB1

SPANXB1
Identifiers
Aliases	SPANXB1 , B1, CT11.2, SPANX-B, SPANXB, SPANXB2, SPANXF1, SPANXF2, SPANX family member B1
External IDs	OMIM: 300669 HomoloGene: 88477 GeneCards: SPANXB1
Gene location (Human)
Chr.	X chromosome (human)
End	141,003,706 bp
Gene ontology
Molecular function	• molecular function ;
Cellular component	• cytoplasm ; • nucleus ;
Biological process	• spermatid development ;
	Sources:Amigo / QuickGO
Orthologs
	728695
	n/a
	ENSG00000227234
	n/a
	Q9NS25
	n/a
	NM_032461 ; NM_145664
	n/a
	NP_115850
	n/a
	Wikidata
View/Edit Human

Last updated May 16, 2021

SPANX family member B1 is a protein that in humans is encoded by the SPANXB1 gene. ^[3]

Function

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode deferentially expressed testis-specific proteins that localize to various subcellular compartments. This particular family member contains an additional 18 nucleotides in its coding region compared to the other family members in the same gene cluster. This family member is also subject to gene copy number variation. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatozoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Apr 2014].

Related Research Articles

Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene.

Cancer/testis antigen 1 also known as LAGE2 or LAGE2B is a protein that in humans is encoded by the CTAG1B gene. It is most often referenced by its alias NY-ESO-1.

Nuclear autoantigenic sperm protein is a protein that in humans is encoded by the NASP gene. Multiple isoforms are encoded by transcript variants of this gene.

Melanoma-associated antigen 3 (MAGE-A3) is a protein that in humans is encoded by the MAGEA3 gene.

Melanoma-associated antigen 4 is a protein that in humans is encoded by the MAGEA4 gene.

Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic or glyceraldehyde-3-phosphate dehydrogenase, testis-specific is an enzyme that in humans is encoded by the GAPDHS gene.

Four and a half LIM domains protein 5 is a protein that in humans is encoded by the FHL5 gene.

Melanoma-associated antigen 2 is a protein that in humans is encoded by the MAGEA2 gene.

Cystatin-8 is a protein that in humans is encoded by the CST8 gene.

Melanoma-associated antigen C2 is a protein that in humans is encoded by the MAGEC2 gene.

Melanoma-associated antigen B2 is a protein that in humans is encoded by the MAGEB2 gene.

Sperm acrosome membrane-associated protein 3 is a protein that in humans is encoded by the SPACA3 gene. It may be involved in adhesion to the egg before the egg is fertilized.

Calcium-binding tyrosine phosphorylation-regulated protein is a protein that in humans is encoded by the CABYR gene.

Sperm protein associated with the nucleus on the X chromosome A is a protein that in humans is encoded by the SPANXA1 gene.

Kinesin heavy chain isoform 5C is a protein that in humans is encoded by the KIF5C gene.

Melanoma-associated antigen 12 is a protein that in humans is encoded by the MAGEA12 gene.

Cysteine-rich secretory protein 2 is a cysteine-rich secretory protein that in humans is encoded by the CRISP2 gene.

Melanoma-associated antigen 9 is a protein that in humans is encoded by the MAGEA9 gene.

OLIGO Primer Analysis Software was the first publicly available software for DNA primer design. The first papers describing this software were published in 1989 and 1990, and consecutive upgrades in the 1990s and 2000s, all have been cited together over 600 times in scientific journals and over 500 times in patents. The program is a comprehensive real time PCR primer and probe search and analysis tool, and also does other tasks such as siRNA and molecular beacon searches, open reading frame and restriction enzyme analysis etc. It has been created and maintained by Wojciech Rychlik and Piotr Rychlik. The OLIGO has been reviewed several times in scientific journals, for the first time in 1991 in a review in Critical Reviews in Biochemistry and Molecular Biology, and for its next upgrades.

CatSper1, is a protein which in humans is encoded by the CATSPER1 gene. CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000227234 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SPANX family member B1" . Retrieved 2018-07-10.

Wang Z, Zhang Y, Liu H, Salati E, Chiriva-Internati M, Lim SH (February 2003). "Gene expression and immunologic consequence of SPAN-Xb in myeloma and other hematologic malignancies". Blood. 101 (3): 955–60. doi: 10.1182/blood-2002-06-1930 . PMID 12393489.
Hansen MA, Nielsen JE, Retelska D, Larsen N, Leffers H (February 2008). "A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family". Mol. Reprod. Dev. 75 (2): 219–29. doi:10.1002/mrd.20651. PMID 17342728.
Salemi M, Bosco P, Calì F, Calogero AE, Soma PF, Galia A, Lanzafame M, Romano C, Vicari E, Grasso G, Siragò P, Rappazzo G (August 2008). "SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Sicilian patients with melanoma". Melanoma Res. 18 (4): 295–9. doi:10.1097/CMR.0b013e32830aaa90. PMID 18626316.
Salemi M, Bosco P, Calì F, Calogero AE, Soma PF, Galia A, Lanzafame M, Romano C, Vicari E, Grasso G, Siragò P, Rappazzo G (August 2008). "SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Sicilian patients with melanoma". Melanoma Res. 18 (4): 295–9. doi:10.1097/CMR.0b013e32830aaa90. PMID 18626316.
Salemi M, Romano C, Barone C, Calí F, Caraci F, Romano C, Scavuzzo C, Scillato F, Salluzzo MG, Piccione M, Martines M, Corsello G, Nicoletti F, Bosco P (April 2009). "SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes". J. Genet. 88 (1): 93–7. doi:10.1007/s12041-009-0013-2. PMID 19417550.
Hansen S, Eichler EE, Fullerton SM, Carrell D (February 2010). "SPANX gene variation in fertile and infertile males". Syst Biol Reprod Med. 55: 18–26. doi:10.3109/19396360903312015. PMID 20073942.
Hansen S, Eichler EE, Fullerton SM, Carrell D (February 2010). "SPANX gene variation in fertile and infertile males". Syst Biol Reprod Med. 55: 18–26. doi:10.3109/19396360903312015. PMID 20073942.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000227234 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: SPANX family member B1" . Retrieved 2018-07-10.

[1]

[2]

[3]

SPANXB1

Contents

Function

Related Research Articles

References

Further reading