SULT1C4

SULT1C4
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2AD1, 2GWH
Identifiers
Aliases	SULT1C4 , SULT1C, SULT1C2, sulfotransferase family 1C member 4
External IDs	OMIM: 608357; HomoloGene: 41383; GeneCards: SULT1C4; OMA:SULT1C4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q12.3 Start 108,377,911 bp [1] End 108,388,989 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone gallbladder left ovary right lung ganglionic eminence right ovary right uterine tube hypothalamus canal of the cervix caudate nucleus n/a More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity sulfotransferase activity aryl sulfotransferase activity Cellular component cytoplasm cytosol cellular component Biological process sulfation ethanol catabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27233 n/a Ensembl ENSG00000198075 n/a UniProt O75897 n/a RefSeq (mRNA) NM_006588 NM_001321770 n/a RefSeq (protein) NP_001308699 NP_006579 n/a Location (UCSC) Chr 2: 108.38 – 108.39 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Sulfotransferase 1C4 is an enzyme that in humans is encoded by the SULT1C4 gene. ^{[3] [4] [5]}

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities.

The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000198075 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Freimuth RR, Raftogianis RB, Wood TC, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM (Jul 2000). "Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization". Genomics. 65 (2): 157–65. doi:10.1006/geno.2000.6150. PMID   10783263.
4. Sakakibara Y, Yanagisawa K, Katafuchi J, Ringer DP, Takami Y, Nakayama T, Suiko M, Liu MC (Jan 1999). "Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene". J Biol Chem. 273 (51): 33929–35. doi: 10.1074/jbc.273.51.33929 . PMID   9852044.
5. "Entrez Gene: SULT1C2 sulfotransferase family, cytosolic, 1C, member 2".

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi: 10.1096/fasebj.11.1.9034160 . PMID   9034160. S2CID   12532583.
• Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112–113: 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID   10720750.
• Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. doi:10.1016/S0009-2797(00)00202-7. PMID   11154739.
• Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID   11535246.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Allali-Hassani A, Pan PW, Dombrovski L, et al. (2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLOS Biol. 5 (5): e97. doi: 10.1371/journal.pbio.0050097 . PMC   1847840 . PMID   17425406.