Simon Wain-Hobson OBE (born 25 May 1953) is a British/French microbiologist, professor of molecular retrovirology at the Pasteur Institute in Paris, director of the French National HPV Reference Laboratory, and board chairman of the Foundation for Vaccine Research in Washington, D.C.
Wain-Hobson obtained a PhD in biochemistry from the University of Oxford in 1977, served as a post-doctoral fellow at the Weizmann Institute of Science from 1977 to 1980, and thereafter moved to the Pasteur Institute in Paris. Wain-Hobson and his research group at the Pasteur Institute were the first to publish the sequence of HIV, which was also the first full sequence of a primate lentivirus. [1] [2] Wain-Hobson is holder of licensed patents on HIV genomes and diagnostics. [3]
Wain-Hobson's most recent work involves the role of APOBEC3 in cancer and other human diseases. [4] [5] Wain-Hobson is a co-founder of Invectys Inc., a biopharmaceutical company focused on the development of immunotherapy approaches to the treatment of cancer.
Wain-Hobson won the André Lwoff prize in 1996 and Athena prize from the French Academy of Sciences in 2007 and is Officier de la Légion d’Honneur. [6]
Wain-Hobson was appointed Officer of the Order of the British Empire (OBE) in the 2022 New Year Honours for services to virology. [7]
Pierre Paul Émile Roux FRS was a French physician, bacteriologist and immunologist. Roux was one of the closest collaborators of Louis Pasteur (1822–1895), a co-founder of the Pasteur Institute, and responsible for the institute's production of the anti-diphtheria serum, the first effective therapy for this disease. Additionally, he investigated cholera, chicken-cholera, rabies, and tuberculosis. Roux is regarded as a founder of the field of immunology.
Luc Montagnier was a French virologist and joint recipient, with Françoise Barré-Sinoussi and Harald zur Hausen, of the 2008 Nobel Prize in Physiology or Medicine for his discovery of the human immunodeficiency virus (HIV). He worked as a researcher at the Pasteur Institute in Paris and as a full-time professor at Shanghai Jiao Tong University in China.
The Pasteur Institute is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vaccines for anthrax and rabies. The institute was founded on 4 June 1887, and inaugurated on 14 November 1888.
Ronald Mark Evans is an American Biologist, Professor and Head of the Salk’s Gene Expression Laboratory, and the March of Dimes Chair in Molecular and Developmental Biology at the Salk Institute for Biological Studies in La Jolla, California and a Howard Hughes Medical Institute Investigator. Dr. Ronald M. Evans is known for his original discoveries of nuclear hormone receptors (NR), a special class of transcriptional factor, and the elucidation of their universal mechanism of action, a process that governs how lipophilic hormones and drugs regulate virtually every developmental and metabolic pathway in animals and humans. Nowadays, NRs are among the most widely investigated group of pharmaceutical targets in the world, already yielding benefits in drug discovery for cancer, muscular dystrophies, osteoporosis, type II diabetes, obesity, and cardiovascular diseases. His current research focuses on the function of nuclear hormone signaling and their function in metabolism and cancer.
Jean Bernard was a French physician and haematologist. He was professor of haematology and director of the Institute for Leukaemia at the University of Paris. After graduating in medicine in Paris in 1926 he commenced his laboratory training with the bacteriologist Gaston Ramon at the Pasteur Institute in 1929.
Pascale Cossart is a French bacteriologist who is affiliated with the Pasteur Institute of Paris. She is the foremost authority on Listeria monocytogenes, a deadly and common food-borne pathogen responsible for encephalitis, meningitis, bacteremia, gastroenteritis, and other diseases.
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 also known as C->U-editing enzyme APOBEC-1 is a protein that in humans is encoded by the APOBEC1 gene.
DNA dC->dU-editing enzyme APOBEC-3C is a protein that in humans is encoded by the APOBEC3C gene.
Robert Charles Gallo is an American biomedical researcher. He is best known for his role in establishing the human immunodeficiency virus (HIV) as the infectious agent responsible for acquired immune deficiency syndrome (AIDS) and in the development of the HIV blood test, and he has been a major contributor to subsequent HIV research.
Françoise Barré-Sinoussi is a French virologist and Director of the Regulation of Retroviral Infections Division and Professor at the Institut Pasteur in Paris, France. Born in Paris, France, Barré-Sinoussi performed some of the fundamental work in the identification of the human immunodeficiency virus (HIV) as the cause of AIDS. In 2008, Barré-Sinoussi was awarded the Nobel Prize in Physiology or Medicine, together with her former mentor, Luc Montagnier, for their discovery of HIV. She mandatorily retired from active research on August 31, 2015 and fully retired by some time in 2017.
Frances Rosemary Balkwill is an English scientist, Professor of Cancer Biology at Queen Mary University of London, and author of children's books about scientific topics.
DNA dC->dU-editing enzyme APOBEC-3H, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H or APOBEC-related protein 10, is a protein that in humans is encoded by the APOBEC3H gene.
André Choulika is a biotechnologist, the inventor of nuclease-based genome editing and a pioneer in the analysis and use of meganucleases to modify complex genomes.
Sir Stewart Thomas Cole is a British/French microbiologist. He has been the director general of the Pasteur Institute since January 2018.
Éric A. Cohen is a Canadian molecular virologist whose research is focused on human immunodeficiency virus (HIV)-host interactions that govern viral replication and persistence.
Anne Dejean-Assémat is a French molecular biologist working on the mechanisms leading to the development of human cancers. Professor at the Pasteur Institute and Research Director at Inserm, she heads the laboratory of Nuclear Organization and Oncogenesis at the Pasteur Institute.
Pierre Charneau is a French virologist, inventor, and head of the Molecular Virology and Vaccinology Unit (VMV) at the Pasteur Institute and an acknowledged specialist in HIV, lentiviral gene transfer vectors, and their medical applications. His discovery of the central DNA-flap structure in the HIV genome, and its role in viral entry into the nucleus of the infected cell, grounded the optimization of lentiviral vectors and allowed for more than 20 years of development in gene therapy and vaccines based on this gene delivery technology. Charneau has published more than 100 research articles and holds 25 patents in the field of HIV and lentiviral vectors.
Gérard Orth was born on February 7, 1936, in Paris is a French virologist, emeritus research director at the CNRS, honorary professor at the Pasteur Institute.
Jean-Claude Weill, is a French biologist, immunologist and member of the French Academy of Sciences.
Pierre Grabar was a French biochemist and immunologist, born in Russia. He was the founding president of the Société Française d'Immunologie. He studied antigen-antibody reactions and developed a "carrier" theory of antibody function. His award-winning development of Immunoelectrophoresis made it possible to identify specific bodily proteins, opening new avenues in medical research.