Interstate 376 (I-376) is a major auxiliary route of the Interstate Highway System in the US state of Pennsylvania, located within the Allegheny Plateau. It runs from I-80 near Sharon south and east to a junction with the Pennsylvania Turnpike in Monroeville, after having crossed the Pennsylvania Turnpike at an interchange in Big Beaver. The route serves Pittsburgh and its surrounding areas and is the main access road to Pittsburgh International Airport (PIT). Portions of the route are known as the Beaver Valley Expressway, Southern Expressway, and Airport Parkway. Within Allegheny County, the route runs along the majority of the Penn-Lincoln Parkway, known locally as Parkway West and Parkway East. It is currently the ninth-longest auxiliary Interstate route in the system and second only to I-476 within Pennsylvania.
U.S. Route 222 is a U.S. Highway that is a spur of US 22 in the states of Maryland and Pennsylvania. It runs for 95 miles (153 km) from US 1 in Conowingo, Maryland, north to the junction of Interstate 78 (I-78) and Pennsylvania Route 309 in Dorneyville, Pennsylvania. US 222 is almost entirely in Pennsylvania, and serves as the state's principal artery between the Lancaster and Reading areas in the west and the Lehigh Valley in the east.
Interstate 76 (I-76) is an east–west Interstate Highway in the Eastern United States. The highway runs approximately 435 miles (700 km) from an interchange with I-71 west of Akron, Ohio, east to I-295 in Bellmawr, New Jersey. This route is not contiguous with I-76 in Colorado and Nebraska.
Pennsylvania Route 576 (PA Turnpike 576), also known as the Southern Beltway, is a tolled freeway in the southern and western suburbs of Pittsburgh, Pennsylvania, United States. It is envisioned to serve as a southern beltway around the Greater Pittsburgh area between Pittsburgh International Airport and the historic Steel Valley of the Monongahela River.
Pennsylvania Route 611 is a state highway in eastern Pennsylvania running 109.7 mi (176.5 km) from Interstate 95 (I-95) in the southern part of Philadelphia north to I-380 in Coolbaugh Township in the Pocono Mountains.
Pennsylvania Route 32 is a scenic two-lane highway that runs along the west side of the Delaware River in Bucks County, Pennsylvania. Signed north-south, it runs from U.S. Route 1 in Falls Township outside of Morrisville northwest to PA 611 in the village of Kintnersville in Nockamixon Township. PA 32 passes through Washington Crossing Historic Park, a Revolutionary War-themed historical park on the site of George Washington's crossing on the night of December 25–26, 1776. It also passes through the boroughs of Morrisville, Yardley, and New Hope.
Pennsylvania Route 28 is a major state highway, which runs for 98 miles (158 km) from Anderson Street in Pittsburgh to U.S. Route 219 (US 219) in Brockway in Pennsylvania in the United States.
U.S. Route 30 (US 30) is a U.S. Highway that runs east–west across the southern part of Pennsylvania, passing through Pittsburgh and Philadelphia on its way from the West Virginia state line east to the Benjamin Franklin Bridge over the Delaware River into New Jersey.
The Mon–Fayette Expressway is a partially-completed tolled freeway that is planned to eventually link Interstate 68 near Morgantown, West Virginia with Interstate 376 near Monroeville, Pennsylvania. The ultimate goal of the highway is to provide a high speed north–south connection between Morgantown and the eastern side of Pittsburgh while revitalizing economically distressed Monongahela River Valley towns in Fayette and Washington counties, serving as an alternative to Interstate 79 to the west, as well as relieving the PA 51 alignment from Pittsburgh to Uniontown.
Interstate 70 (I-70) is a state highway that is located in the Commonwealth of Pennsylvania in the United States. It runs east to west across the southwest part of Pennsylvania and serves the southern fringe of the Pittsburgh metropolitan area.
Pennsylvania Route 378 (PA 378) is a north-to-south road in Lehigh and Northampton counties in the Lehigh Valley region of the U.S. state of Pennsylvania. The southern terminus is at PA 309 in Center Valley. Its northern terminus is at U.S. Route 22 (US 22) in Bethlehem. The route heads north from PA 309 as a two-lane undivided road through Upper Saucon Township and Lower Saucon Township before crossing South Mountain into Bethlehem. Here, PA 378 follows city streets through Bethlehem's South Side, intersecting the northern terminus of PA 412. The route crosses the Lehigh River and becomes a four-lane freeway that continues north to US 22. PA 378 is the only highway from US 22 to Center City Bethlehem, and a quick route for visitors traveling to the Wind Creek Bethlehem casino resort on the city's South Side.
Interstate 95 (I-95) is a major north–south Interstate Highway that runs along the East Coast of the United States from Miami, Florida, north to the Canada–United States border at Houlton, Maine. In the state of Pennsylvania, it runs 44.25 miles (71.21 km) from the Delaware state line near Marcus Hook in Delaware County in the southeastern part of the state northeast to the Delaware River–Turnpike Toll Bridge at the New Jersey state line near Bristol in Bucks County, closely paralleling the New Jersey state line for its entire length through Pennsylvania.
Pennsylvania Route 51 is a major state highway that is located in Western Pennsylvania in the United States. It runs for 89 miles (143 km) from Uniontown to the Ohio state line near Darlington, where it connects with Ohio State Route 14.
Pennsylvania Route 48 is an 18.9-mile-long (30.4 km) state highway located in the Pittsburgh, Pennsylvania area. The route is predominantly a two-lane highway as it runs through McKeesport and other suburbs. The entire routing of PA 48 is part of the Orange Belt, both reaching their southern termini at PA 51, southeast of Elizabeth. Until 1998, the northern terminus of PA 48 was at the intersection of Old Haymaker and Center Roads, about 1/2 mile from its current terminus at U.S. Route 22 Business in Monroeville.
Pennsylvania Route 33 is a 27.7-mile-long (44.6 km) freeway in eastern Pennsylvania. The highway runs from its interchange with Interstate 78 (I-78) south of Easton in the Lehigh Valley to I-80 and PA 611 west of Stroudsburg.
Pennsylvania Route 23 is an 81.14-mile-long (130.58 km) state highway in southeastern Pennsylvania. The route begins at PA 441 in Marietta and heads east to U.S. Route 1 at City Avenue on the border of Lower Merion Township and Philadelphia. PA 23 begins at Marietta in Lancaster County and continues east to Lancaster, where it passes through the city on a one-way pair of streets and intersects US 222 and US 30.
Pennsylvania Route 45 is an 86-mile-long (138 km) state highway that is located in central Pennsylvania, United States. The western terminus of the route is situated at PA 453 in Morris Township near the community of Water Street. The eastern terminus is located at PA 642 west of the small town of Mooresburg.
The Memorial Bridge is a structure that crosses the Youghiogheny River, connecting the eastern and western shores of Connellsville, Pennsylvania, US.
The following is a list of former state routes in Pennsylvania. These roads are now either parts of other routes or no longer carry a traffic route number. This list also includes original routes of numbers that were decommissioned and later reactivated in other locations in which most of these are still active today.
I-70 
