Spence is a surname. Notable people with the surname include:
- Ara Spence (1793–1866), American judge from Maryland
- Basil Spence (1907–1976), British architect
- Brent Spence (1874–1967), American politician, attorney, and banker
- Bruce Spence (born 1945), New Zealand-born Australian actor
- Catherine Helen Spence (1825–1910), Australian reformer and suffragist
- Charles Spence, experimental psychologist at the University of Oxford
- Derek Spence (born 1952), Irish footballer
- Djed Spence (born 2000), English footballer
- E. Lee Spence, American author, editor, adventurer and underwater archaeologist
- Errol Spence Jr., American boxer
- Fiona Spence, British-Australian actress
- Floyd Spence, American politician
- George Spence (Canadian politician) (1880–1975), Canadian politician
- George Spence (MP) (1787–1850), British politician
- George Spence (footballer, born 1877) (1877–?), Scottish footballer
- George Spence (footballer, born 1904) (1904–?), English footballer
- Gerry Spence, American trial lawyer
- James Spence, Scottish Surgeon
- Joe Spence (footballer born 1898), English footballer for Manchester United in the 1920s
- Joe Spence (footballer born 1925), English footballer for York City in the 1950s
- John Brodie Spence, South Australian banker and politician, brother of Catherine
- John S. Spence, American politician from Maryland
- John Selby Spence (Catholic bishop), American Catholic bishop
- John Spence (politician), British politician
- John Spence (musician), founding member of the band No Doubt
- Jonathan Spence, English historian
- Jordan Spence (born 1990), English (soccer) footballer
- Jordan Spence (ice hockey) (born 2001), Japanese Canadian
- Joseph Spence (author), English anecdotist
- Joseph Spence (musician), Bahamian guitarist and blues musician
- Julian Spence (1929–1990), American football player
- Kenneth Spence, prominent American psychologist
- Lansford Spence, Jamaican sprinter
- Lewis Spence, journalist and writer
- Linda Spence, Irish-Scottish cricketer
- Louie Spence, British dancer
- Malcolm Spence (ice hockey) (born 2006), Canadian ice hockey player
- Michael Spence, American economist
- Nicky Spence, Scottish opera singer
- Noah Spence, American football player
- Phil Spence, American basketball player and coach
- Robert Spence (1905–1976), British nuclear chemist and former Director of the AERE
- Russell Spence, English race car driver
- Sam Spence (1927–2016), American composer and musician
- Shaun Spence (born 1991), Australian rugby player
- Sion Spence (born 2000), Welsh footballer
- Skip Spence (1946–1999), American rock musician
- Steve Spence, American long-distance runner
- Thomas Spence (1750–1814), English Radical democrat
- Toby Spence (born 1969), English tenor
- Vivienne Spence, Jamaican track and field athlete
- William Spence (1846–1926), Australian trade unionist and politician
- William Wallace Spence (1815–1915), American financier
- Willie Spence (1999–2022), American singer
- Wishart Spence, Canadian judge
This page lists people with the surname Spence.
If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.
If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.