The spiroindolones are a class of compounds in which an indolone ring is substituted with another ring in a spiro arrangement.
Alkaloids in this class include horsfiline, rhynchophylline, gelsemine, carapanaubine, and maremycin E.
Spiroindolones are also an emerging class of antimalarial drugs [1] whose mode of action is to inhibit protein synthesis in the target parasite. The most advanced compound in this class in terms of drug development is cipargamin (NITD609). [2]
