Endometriosis is a disease of the female reproductive system in which cells similar to those in the endometrium, the layer of tissue that normally covers the inside of the uterus, grow outside the uterus. Lesions can be found on ovaries, fallopian tubes, tissue around the uterus and ovaries (peritoneum), intestines, bladder, and diaphragm; it may also occur in other parts of the body. Some symptoms include pelvic pain, heavy periods, pain with bowel movements, painful urination, and infertility. Nearly half of those affected have chronic pelvic pain, while in 70% pain occurs during menstruation. Pain during sexual intercourse is also common. Infertility occurs in up to half of affected individuals. About 25% of individuals have no symptoms and 85% of those seen with infertility in a tertiary center have no pain. Endometriosis can have both social and psychological effects.
In vitro fertilisation (IVF) is a process of fertilisation where an egg is combined with sperm in vitro. The process involves monitoring and stimulating a woman's ovulatory process, removing an ovum or ova from her ovaries and letting sperm fertilise them in a culture medium in a laboratory. After the fertilised egg (zygote) undergoes embryo culture for 2–6 days, it is transferred by catheter into the uterus, with the intention of establishing a successful pregnancy.
Infertility is the inability of a person, animal or plant to reproduce by natural means. It is usually not the natural state of a healthy adult, except notably among certain eusocial species. It is the normal state of a human child or other young offspring, because they have not undergone puberty, which is the body's start of reproductive capacity.
Female infertility refers to infertility in women. It affects an estimated 48 million women, with the highest prevalence of infertility affecting women in South Asia, Sub-Saharan Africa, North Africa/Middle East, and Central/Eastern Europe and Central Asia. Infertility is caused by many sources, including nutrition, diseases, and other malformations of the uterus. Infertility affects women from around the world, and the cultural and social stigma surrounding it varies.
A hydrosalpinx is a condition that occurs when a Fallopian tube is blocked and fills with serous or clear fluid near the ovary. The blocked tube may become substantially distended giving the tube a characteristic sausage-like or retort-like shape. The condition is often bilateral and the affected tubes may reach several centimeters in diameter. The blocked tubes cause infertility. A Fallopian tube filled with blood is a hematosalpinx, and with pus a pyosalpinx.
Reproductive medicine is a branch of medicine concerning the male and female reproductive systems. It encompasses a variety of reproductive conditions, their prevention and assessment, as well as their subsequent treatment and prognosis.
The fertiloscope is a type of laparoscope, modified to make it suitable for trans-vaginal application, which is used in the diagnosis and treatment of female infertility.
Linda Gay Griffith is an American biological engineer, and Professor of Biological Engineering and Mechanical Engineering at Massachusetts Institute of Technology, where she also directs the Center for Gynepathology Research.
Endometriosis and its complications are a major cause of female infertility. Endometriosis is a dysfunction characterized by the migration of endometrial tissue to areas outside of the endometrium of the uterus. The most common places to find stray tissue are on ovaries and fallopian tubes, followed by other organs in the lower abdominal cavity such as the bladder and intestines. Typically, the endometrial tissue adheres to the exteriors of the organs, and then creates attachments of scar tissue called adhesions that can join adjacent organs together. The endometrial tissue and the adhesions can block a fallopian tube and prevent the meeting of ovum and sperm cells, or otherwise interfere with fertilization, implantation and, rarely, the carrying of the fetus to term.
Simin Liu is an American physician researcher. He holds leadership positions internationally in the research of nutrition, genetics, epidemiology, and environmental and biological influences of complex diseases related to cardiometabolic health in diverse population. His research team has uncovered new mechanisms and risk-factors as well as developed research frameworks for diabetes and cardiovascular diseases. Liu's laboratory conducts research mainly in the United States, though the group has had research collaborations, teaching, and service activities in six of the Seven Continents.
Yasmin Ahmed Almubarak Altwaijri is a Senior Scientist and the Head of Epidemiology Research at King Faisal Specialist Hospital and Research Centre (KFSH&RC) in Riyadh, Saudi Arabia. As the Head of Epidemiology Research, she studies the causes and effects of diseases and illnesses within a specific country, in her case Saudi Arabia. She studies the prevalence of conditions such as obesity and mental illness in Saudi society, and is active in advocating for social and political changes to promote better health.
Lauren Anne Wise is a Canadian-American epidemiologist and Professor in the Department of Epidemiology at Boston University School of Public Health.
Allison Walsh Kurian is an American medical oncologist. She is a Professor of Medicine and Epidemiology & Population Health at Stanford University and an oncologist at the Stanford Cancer Institute.
Nancy Sarah Goroff is an American organic chemist who is chair of the chemistry department at Stony Brook University. Her research investigates conjugated organic molecules, including polymers, halocarbons and buckyballs. During the 2020 United States elections Goroff ran to represent New York's 1st congressional district, and was defeated by the incumbent, Lee Zeldin.
Alison Ellen Field is an American epidemiologist. Field currently serves as professor and chair of epidemiology at the Brown University School of Public Health and professor of pediatrics at Brown's Alpert Medical School.
Krina Tynke Zondervan is a Dutch biomedical scientist who is a Professor of Genomic Epidemiology at the University of Oxford. She serves on the board of the World Endometriosis Society.
Baidyanath Chakrabarty was an Indian doctor and reproductive health specialist who was considered a pioneer of reproductive medicine in the country. He was the founder of the Institute of Reproductive Medicine, in Salt Lake, Kolkata, focused on assisted reproductive research. In a career spanning over seven decades, he had performed over 4,000 IVF procedures.
Francine Laden is an American epidemiologist who is Professor of Environmental Epidemiology at the Harvard T.H. Chan School of Public Health. Her research has investigated the environmental epidemiology of chronic disease. She serves as co-director of the Harvard University and Boston University center for research on environmental and social stressors in housing across the life course. Laden has also served on the United States Environmental Protection Agency advisory board.
Susan Hankinson is an American cancer researcher who is the Distinguished Professor of Epidemiology at the University of Massachusetts Amherst. Her research considers cancer epidemiology and the etiology of breast cancer. Her work has demonstrated the relationship between hormones and breast cancer risk. In 2023, she was awarded the American Association for Cancer Research Award for Research Excellence in Cancer Epidemiology and Prevention.
A. Heather Eliassen is an American public health researcher who is a Professor of Epidemiology at the Harvard T.H. Chan School of Public Health. Her research considers the epidemiology of breast cancer and the identification of modifiable risk factors to reduce breast cancer risk.
