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Max Ludwig Henning Delbrück was a German–American biophysicist who participated in launching the molecular biology research program in the late 1930s. He stimulated physical scientists' interest into biology, especially as to basic research to physically explain genes, mysterious at the time. Formed in 1945 and led by Delbrück along with Salvador Luria and Alfred Hershey, the Phage Group made substantial headway unraveling important aspects of genetics. The three shared the 1969 Nobel Prize in Physiology or Medicine "for their discoveries concerning the replication mechanism and the genetic structure of viruses". He was the first physicist to predict what is now called Delbrück scattering.
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Marc Wallace Kirschner is an American cell biologist and biochemist and the founding chair of the Department of Systems Biology at Harvard Medical School. He is known for major discoveries in cell and developmental biology related to the dynamics and function of the cytoskeleton, the regulation of the cell cycle, and the process of signaling in embryos, as well as the evolution of the vertebrate body plan. He is a leader in applying mathematical approaches to biology. He is the John Franklin Enders University Professor at Harvard University. In 1989 he was elected to the National Academy of Sciences. In 2021 he was elected to the American Philosophical Society.
The repressilator is a genetic regulatory network consisting of at least one feedback loop with at least three genes, each expressing a protein that represses the next gene in the loop. In biological research, repressilators have been used to build cellular models and understand cell function. There are both artificial and naturally-occurring repressilators. Recently, the naturally-occurring repressilator clock gene circuit in Arabidopsis thaliana and mammalian systems have been studied.
James Joseph Collins is an American biomedical engineer and bioengineer who serves as the Termeer Professor of Medical Engineering & Science at the Massachusetts Institute of Technology (MIT), where he is also a director at the MIT Abdul Latif Jameel Clinic for Machine Learning in Health.
The Max Delbruck Prize, formerly known as the Biological physics prize, is awarded by the Division of Biological Physics of the American Physical Society, to recognize and encourage outstanding achievement in biological physics research. The prize was established in 1981, and renamed for Max Delbrück in 2006. The award consists of $10,000, an allowance for travel to the meeting where the prize is awarded, and a certificate. It was presented biennially in even-numbered years until 2014, and will be presented annually starting 2015.
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Uri Alon is a Professor and Systems Biologist at the Weizmann Institute of Science. His highly cited research investigates gene expression, network motifs and the design principles of biological networks in Escherichia coli and other organisms using both computational biology and traditional experimental wet laboratory techniques.
Johan Paulsson is a Swedish mathematician and systems biologist at Harvard Medical School. He is a researcher in systems biology and stochastic processes, specializing in stochasticity in gene networks and plasmid reproduction.
Jean-Jacques Weigle was a Swiss molecular biologist at Caltech and formerly a physicist at the University of Geneva from 1931 to 1948. He is known for his major contributions on field of bacteriophage λ research, focused on the interactions between those viruses and their E. coli hosts.
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Yoshinori Ohsumi is a Japanese cell biologist specializing in autophagy, the process that cells use to destroy and recycle cellular components. Ohsumi is a professor at Institute of Science Tokyo's Institute of Innovative Research. He received the Kyoto Prize for Basic Sciences in 2012, the 2016 Nobel Prize in Physiology or Medicine, and the 2017 Breakthrough Prize in Life Sciences for his discoveries of mechanisms for autophagy.
Tim Stearns is an American biologist and university administrator, and is the Dean of Graduate and Postgraduate Studies, Vice President of Education, and Head of Laboratory at The Rockefeller University. Stearns was formerly the Frank Lee and Carol Hall Professor in the Department of Biology at Stanford University, with appointments in the Department of Genetics and the Cancer Center in the Stanford Medical School. Stearns served as chair of the Department of Biology at Stanford as well as Acting Dean of Research and Senior Associate Vice Provost of Research. Stearns is an HHMI Professor, and is a member of JASON, a scientific advisory group. He has served on the editorial boards of The Journal of Cell Biology, Genetics and Molecular Biology of the Cell.
Naama Barkai is an Israeli systems biologist and professor for Molecular Genetics and Physics of Complex Systems at the Weizmann Institute of Science in Rehovot, Israel, and a member of the European Molecular Biology Organization (EMBO).
Gustavo A. Stolovitzky is an Argentine-American computational systems biologist. He was the CSO of Sema4 and then of GeneDx until December 2023. Between 1998 and 2021 he was a researcher and executive at IBM Research. At IBM he served in several roles including founding chair of the Exploratory Life Sciences Council and director of the Translational Systems Biology and Nano-Biotechnology Program at IBM Research. From 2013 to 2018 he was Adjunct professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai and from 2007 he has been an Adjunct Associate Professor of Biomedical Informatics at Columbia University. His research has been cited more than 29,000 times
Genetic regulatory circuits is a concept that evolved from the Operon Model discovered by François Jacob and Jacques Monod. They are functional clusters of genes that impact each other's expression through inducible transcription factors and cis-regulatory elements.
Nathalie Q. Balaban is an Israeli biophysicist and systems biologist. She is a full professor at the Racah Institute of Physics at the Hebrew University of Jerusalem. and a member of the European Academy of Microbiology (EAM), the American Academy of Microbiology (AAM) and the European Molecular Biology Organization (EMBO).
References
- ↑ "Mendel Medal".
- ↑ Stanislas Leibler Appointed to the Faculty of the Institute for Advanced Study, IAS press release, April 22, 2009
- ↑ Editorial: Ten years of synergy, Nature 463, 269-270 (21 January 2010), doi:10.1038/463269b
- ↑ A synthetic oscillatory network of transcriptional regulators, Michael B. Elowitz & Stanislas Leibler, Nature 403, 335-338 (20 January 2000), doi:10.1038/35002125
- ↑ American Physical Society announces 2015 Prize & Award Recipients, 2015 Max Delbruck PrizeIn Biological Physics
- ↑ National Academy of Sciences Members and Foreign Associates Elected, News from the National Academy of Sciences, National Academy of Sciences, May 3, 2016, retrieved 2016-05-14.
