Steven Kliewer

Last updated

Steven Kliewer is an American biochemist, a significant figure in his field, currently the Nancy B. and Jake L. Hamon Distinguished Chair in Basic Cancer Research at University of Texas Southwestern Medical Center. In 2015, he was elected to the National Academy of Sciences. He, along with David Mangelsdorf, identified the ligands and physiologic functions of a number of orphan nuclear receptors that then discovered two new signaling pathways mediated by the endocrine factors FGF19 and FGF21, which has become a significant accomplishment in the field. [1] [2] [3]

Related Research Articles

Steven Weinberg American theoretical physicist

Steven Weinberg was an American theoretical physicist and Nobel laureate in physics for his contributions with Abdus Salam and Sheldon Glashow to the unification of the weak force and electromagnetic interaction between elementary particles.

Ellen S. Vitetta is the director of the Cancer Immunobiology Center at the University of Texas Southwestern Medical Center in Dallas.

Michael Posner (psychologist) American psychologist (born 1936)

Michael I. Posner is an American psychologist who is a researcher in the field of attention, and the editor of numerous cognitive and neuroscience compilations. He is emeritus professor of psychology at the University of Oregon, and an adjunct professor at the Weill Medical College in New York. A Review of General Psychology survey, published in 2002, ranked Posner as the 56th most cited psychologist of the 20th century.

Manjul Bhargava Canadian-American mathematician

Manjul Bhargava is a Canadian-American mathematician. He is the Brandon Fradd, Class of 1983, Professor of Mathematics at Princeton University, the Stieltjes Professor of Number Theory at Leiden University, and also holds Adjunct Professorships at the Tata Institute of Fundamental Research, the Indian Institute of Technology Bombay, and the University of Hyderabad. He is known primarily for his contributions to number theory.

Fibroblast growth factor 23

Fibroblast growth factor 23 (FGF23) is a protein that in humans is encoded by the FGF23 gene. FGF23 is a member of the fibroblast growth factor (FGF) family which participates in phosphate and vitamin D metabolism and regulation.

FGF19

Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism. Reduced synthesis, and blood levels, may be a factor in chronic bile acid diarrhea and in certain metabolic disorders.

FGF21 Protein-coding gene in the species Homo sapiens

Fibroblast growth factor 21 is a protein that in mammals is encoded by the FGF21 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family and specifically a member of the endocrine subfamily which includes FGF23 and FGF15/19. FGF21 is the primary endogenous agonist of the FGF21 receptor, which is composed of the co-receptors FGF receptor 1 and β-Klotho. Loss of β

Subra Suresh

Subra Suresh is an Indian-American bioengineer, materials scientist, and academic administrator. On 1 January 2018, he was inaugurated as the fourth President of Singapore's Nanyang Technological University (NTU), where he is also the inaugural Distinguished University Professor. Subra Suresh plans on stepping down from his role as the President of NTU at the end of 2022. He was the Vannevar Bush Professor of Engineering at the Massachusetts Institute of Technology (MIT), and Dean of the School of Engineering at MIT from 2007 to 2010 before being appointed as Director of the National Science Foundation (NSF) by Barack Obama, where he served from 2010 to 2013. He was the president of Carnegie Mellon University (CMU) from 2013 to 2017.

Bikash Sinha Indian physicist

Bikash Sinha is an Indian physicist, active in the fields of nuclear physics and high energy physics. Bikash Sinha was the director of the Saha Institute of Nuclear Physics and Variable Energy Cyclotron Centre and the chairman of the Board of Governors of the National Institute of Technology, Durgapur in June 2005. He retired from service as the director of Variable Energy Cyclotron Centre and the Saha Institute of Nuclear Physics in June 2009. Presently he is the Homi Bhabha Chair Professor of the Variable Energy Cyclotron Centre. He is also a member of scientific advisory board to the Prime Minister of India. He received Padma Shri in 2001 and Padma Bhushan in 2010.

Frederick Grinnell (biologist) American biologist

Frederick Grinnell is an American cell biologist, also known for his work in bioethics. Currently, he is the Robert McLemore Professor of Medical Science in the department of cell biology at UT Southwestern Medical Center in Dallas, Texas. He took his undergraduate degree in chemistry at Clark University (1966) and Ph.D. in biochemistry at Tufts University (1970). He joined the faculty at UT Southwestern in 1972 and founded the Ethics in Science and Medicine Program and Ethics Grand Rounds in 1998.

Fibroblast growth factor 15 is a protein in mouse encoded by the Fgf15 gene. It is a member of the fibroblast growth factor (FGF) family but, like FGF19, FGF21 and FGF23, has endocrine functions. FGF19 is the orthologous protein in humans. They are often referred together as FGF15/19.

Peter J. O'Donnell, Jr. was an American businessman, securities investor and philanthropist. From 1962 to 1969, he was the Texas Republican state chair. In 1963, he was also the national chair of the Draft Goldwater Committee.

Jun Ye Chinese-American physicist

Jun Ye is a Chinese-American physicist at JILA, National Institute of Standards and Technology, and the University of Colorado Boulder, working primarily in the field of atomic, molecular and optical physics.

Steven Lanier McKnight, Ph.D, is a professor and former chair of the department of biochemistry at UT Southwestern. His research is in the area of transcriptional regulation.

Lora Hooper is an American biologist, currently the Jonathan W. Uhr Distinguished Chair in Immunology and Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research at University of Texas Southwestern Medical Center. In 2015, she was elected to the National Academy of Sciences.

David J. Mangelsdorf is an American biologist and chemist, currently the Alfred J. Gilman Distinguished Chair in Pharmacology, Raymond and Ellen Willie Distinguished Chair in Molecular Neuropharmacology at University of Texas Southwestern Medical Center. In 2008, he was elected to the National Academy of Sciences. He, along with Steven Kliewer, identified the ligands and physiologic functions of a number of orphan nuclear receptors that then discovered two new signaling pathways mediated by the endocrine factors FGF19 and FGF21, which has become a significant accomplishment in the field.

Carol A. Tamminga is an American psychiatrist and neuroscientist, focusing in treating psychotic illnesses, such as schizophrenia, psychotic bipolar disorder, and schizoaffective disorder, currently the Lou and Ellen McGinley Distinguished Chair in Psychiatric Research and the Chief of the Translational Neuroscience Division in Schizophrenia at University of Texas Southwestern Medical Center. She hss been Chair of the Department of Psychiatry at UTSW since 2008. She is an Elected Fellow of the National Academy of Medicine. She serves on the advisory boards of the Brain and Behavioral Research Foundation and of the National Institute of Mental Health (NIMH). In 2011 she was awarded the Lieber Prize for Outstanding Achievement in Schizophrenia Research. Tamminga led a study examining whether giving Prozac to fetuses with Down syndrome would improve the functioning of their brains. In her attempt to confirm psychiatric diagnoses biologically, she found "biotypes" or "clusters." Her current research involves mechanisms underlying schizophrenia, especially its most prominent symptoms, psychosis and memory dysfunction.

Kim Orth is the Earl A. Forsythe chair in biomedical science and professor of molecular biology and biochemistry at UT Southwestern. She is a Howard Hughes Medical Institute investigator and a member of the National Academy of Sciences. Her research focuses on bacterial pathogenesis.

Margaret A. Phillips is an American biologist who is the Sam G. Winstead and F. Andrew Bell Distinguished Chair in Biochemistry at the University of Texas Southwestern Medical Center. She was elected a Fellow of the National Academy of Sciences in 2021.

References

  1. "Steven Kliewer". utsouthwestern.edu. Retrieved February 25, 2017.
  2. "Principal Investigators". utsouthwestern.edu. Retrieved February 25, 2017.
  3. "Hooper and Kliewer elected to prestigious National Academy of Sciences". utsouthwestern.edu. April 28, 2015. Retrieved February 25, 2017.