A zoonosis or zoonotic disease is an infectious disease of humans caused by a pathogen that can jump from a non-human vertebrate to a human. When humans infect non-humans, it is called reverse zoonosis or anthroponosis.
I Am Legend is a 1954 post-apocalyptic horror novel by American writer Richard Matheson that was influential in the modern development of zombie and vampire literature and in popularizing the concept of a worldwide apocalypse due to disease. The novel was a success and was adapted into the films The Last Man on Earth (1964), The Omega Man (1971), and I Am Legend (2007). It was also an inspiration for George A. Romero's Night of the Living Dead (1968).
28 Days Later is a 2002 British post-apocalyptic horror film directed by Danny Boyle and written by Alex Garland. It stars Cillian Murphy as a bicycle courier who awakens from a coma to discover the accidental release of a highly contagious, aggression-inducing virus has caused the breakdown of society. Naomie Harris, Christopher Eccleston, Megan Burns, and Brendan Gleeson appear in supporting roles.
In immunology, antiserum is a blood serum containing antibodies that is used to spread passive immunity to many diseases via blood donation (plasmapheresis). For example, convalescent serum, passive antibody transfusion from a previous human survivor, used to be the only known effective treatment for ebola infection with a high success rate of 7 out of 8 patients surviving.
EcoHealth Alliance is a US-based non-governmental organization with a stated mission of protecting people, animals, and the environment from emerging infectious diseases. The nonprofit organization focuses on research aimed at preventing pandemics and promoting conservation in hotspot regions worldwide.
In epidemiology, case fatality rate (CFR) – or sometimes more accurately case-fatality risk – is the proportion of people who have been diagnosed with a certain disease and end up dying of it. Unlike a disease's mortality rate, the CFR does not take into account the time period between disease onset and death. A CFR is generally expressed as a percentage. It is a measure of disease lethality, and thus may change with different treatments. CFRs are most often used for with discrete, limited-time courses, such as acute infections.
Globalization, the flow of information, goods, capital, and people across political and geographic boundaries, allows infectious diseases to rapidly spread around the world, while also allowing the alleviation of factors such as hunger and poverty, which are key determinants of global health. The spread of diseases across wide geographic scales has increased through history. Early diseases that spread from Asia to Europe were bubonic plague, influenza of various types, and similar infectious diseases.
Zombie apocalypse is a subgenre of apocalyptic and post-apocalyptic fiction in which society collapses due to overwhelming swarms of zombies. Typically only a few individuals or small bands of human survivors are left living. In some versions, the reason the dead rise and attack humans is unknown, in others, a parasite or infection is the cause, framing events much like a plague. Some stories have every corpse zombify, regardless of the cause of death, whereas others require exposure to the infection, most commonly in the form of a bite.
Paul Gaetan Tremblay is an American author and editor of horror, dark fantasy, and science fiction. His most widely known novels include A Head Full of Ghosts, The Cabin at the End of the World, and Survivor Song. He has won multiple Bram Stoker Awards and is a juror for the Shirley Jackson Awards.
Rabies is a viral disease that causes encephalitis in humans and other mammals. It was historically referred to as hydrophobia because its victims would panic when offered liquids to drink. Early symptoms can include fever and abnormal sensations at the site of exposure. These symptoms are followed by one or more of the following symptoms: nausea, vomiting, violent movements, uncontrolled excitement, fear of water, an inability to move parts of the body, confusion, and loss of consciousness. Once symptoms appear, the result is virtually always death. The time period between contracting the disease and the start of symptoms is usually one to three months but can vary from less than one week to more than one year. The time depends on the distance the virus must travel along peripheral nerves to reach the central nervous system.
In animals, rabies is a viral zoonotic neuro-invasive disease which causes inflammation in the brain and is usually fatal. Rabies, caused by the rabies virus, primarily infects mammals. In the laboratory it has been found that birds can be infected, as well as cell cultures from birds, reptiles and insects. The brains of animals with rabies deteriorate. As a result, they tend to behave bizarrely and often aggressively, increasing the chances that they will bite another animal or a person and transmit the disease.
Carriers is a 2009 American post-apocalyptic horror film written and directed by Àlex and David Pastor. It stars Lou Taylor Pucci, Chris Pine, Piper Perabo, and Emily VanCamp as four survivors of a viral pandemic attempting to stay alive amid the looming threat of becoming infected. Filmed in 2006, it received a limited release in the United States on September 4, 2009, following Pine's breakout performance in Star Trek earlier that year. It received positive reviews from critics and grossed $5.8 million.
Rabies has been the main plot device or a significant theme in many fictional works. Due to the long history of the virus as well as its neurotropic nature, rabies has been a potent symbol of madness, irrationalism, or an unstoppable plague in numerous fictional works, in many genres. Many notable examples are listed below.
"Epidemiology" is the sixth episode of the second season of the American comedy television series Community, and the 31st episode of the series overall. It originally premiered in the United States on NBC on October 28, 2010 as a special Halloween-themed episode. In the episode, the Dean throws a Halloween themed party on campus. During the party, a few of the partygoers become sick from eating a hazardous substance that the Dean mistook for taco meat bought at an army surplus store. The sickness causes those affected to turn into a violent, zombie-like state that can be passed on through bites. As the study group try to escape, the Dean locks the doors, trapping them inside with the infected.
A superspreading event (SSEV) is an event in which an infectious disease is spread much more than usual, while an unusually contagious organism infected with a disease is known as a superspreader. In the context of a human-borne illness, a superspreader is an individual who is more likely to infect others, compared with a typical infected person. Such superspreaders are of particular concern in epidemiology.
Cryptic rabies refers to infection from unrecognized exposure to rabies virus. It is often phylogenetically traced to bats. It is most often seen in the southern United States. Silver-haired bats and tricolored bats are the two most common bat species associated with this form of infection, though both species are known to have less contact with humans than other bat species such as the big brown bat. That species is common throughout the United States and often roosts in buildings and homes where human contact is more likely.
Redcon-1 is a 2018 British action horror film, starring Katarina Waters, Mark Strange, and Carlos Gallardo. The film was produced by Gallardo and Kevin Eastman. Working titles for the film included Zombie Apocalypse and Zombie City. It is Gallardo's second zombie movie. The film was released in the UK on 28 September 2018.
Wildlife trafficking practices have resulted in the emergence of zoonotic diseases. Exotic wildlife trafficking is a multi-billion dollar industry that involves the removal and shipment of mammals, reptiles, amphibians, invertebrates, and fish all over the world. Traded wild animals are used for bushmeat consumption, unconventional exotic pets, animal skin clothing accessories, home trophy decorations, privately owned zoos, and for traditional medicine practices. Dating back centuries, people from Africa, Asia, Latin America, the Middle East, and Europe have used animal bones, horns, or organs for their believed healing effects on the human body. Wild tigers, rhinos, elephants, pangolins, and certain reptile species are acquired through legal and illegal trade operations in order to continue these historic cultural healing practices. Within the last decade nearly 975 different wild animal taxa groups have been legally and illegally exported out of Africa and imported into areas like China, Japan, Indonesia, the United States, Russia, Europe, and South America.
False information, including intentional disinformation and conspiracy theories, about the scale of the COVID-19 pandemic and the origin, prevention, diagnosis, and treatment of the disease has been spread through social media, text messaging, and mass media. False information has been propagated by celebrities, politicians, and other prominent public figures. Many countries have passed laws against "fake news", and thousands of people have been arrested for spreading COVID-19 misinformation. The spread of COVID-19 misinformation by governments has also been significant.
The COVID-19 lab leak theory, or lab leak hypothesis, is the idea that SARS-CoV-2, the virus that caused the COVID-19 pandemic, came from a laboratory. This claim is highly controversial; most scientists believe the virus spilled into human populations through natural zoonosis, similar to the SARS-CoV-1 and MERS-CoV outbreaks, and consistent with other pandemics in human history. Available evidence suggests that the SARS-CoV-2 virus was originally harbored by bats, and spread to humans from infected wild animals, functioning as an intermediate host, at the Huanan Seafood Market in Wuhan, Hubei, China, in December 2019. Several candidate animal species have been identified as potential intermediate hosts. There is no evidence SARS-CoV-2 existed in any laboratory prior to the pandemic, or that any suspicious biosecurity incidents happened in any laboratory.
