TMSB10

TMSB10
Identifiers
Aliases	TMSB10 , MIG12, TB10, thymosin beta 10
External IDs	OMIM: 188399; GeneCards: TMSB10; OMA:TMSB10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p11.2 Start 84,905,656 bp [1] End 84,906,671 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte mucosa of transverse colon granulocyte ganglionic eminence stromal cell of endometrium right lung upper lobe of left lung mucosa of sigmoid colon tibial nerve Achilles tendon n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding actin monomer binding Cellular component cytoskeleton cytoplasm Biological process actin filament organization regulation of cell migration sequestering of actin monomers Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9168 n/a Ensembl ENSG00000034510 n/a UniProt P63313 n/a RefSeq (mRNA) NM_021103 n/a RefSeq (protein) NP_066926 n/a Location (UCSC) Chr 2: 84.91 – 84.91 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Thymosin beta-10 is a protein that in humans is encoded by the TMSB10 gene. ^{[3] [4] [5]} TMSB10 is a member of the beta-thymosin family of peptides.

TMSB10 plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).^{[ citation needed ]}

References

1. GRCh38: Ensembl release 89: ENSG00000034510 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. McCreary V, Kartha S, Bell GI, Toback FG (Jun 1988). "Sequence of a human kidney cDNA clone encoding thymosin beta 10". Biochem Biophys Res Commun. 152 (2): 862–6. doi:10.1016/S0006-291X(88)80118-9. PMID   3365256.
4. Santelli G, Califano D, Chiappetta G, Vento MT, Bartoli PC, Zullo F, Trapasso F, Viglietto G, Fusco A (Oct 1999). "Thymosin beta-10 gene overexpression is a general event in human carcinogenesis". Am J Pathol. 155 (3): 799–804. doi:10.1016/s0002-9440(10)65178-4. PMC   1866886 . PMID   10487837.
5. "Entrez Gene: TMSB10 thymosin, beta 10".

Further reading

• Tsitsiloni OE, Yialouris PP, Echner H, et al. (1992). "Evidence for the extranuclear localization of thymosins in thymus". Experientia. 48 (4): 398–402. doi:10.1007/BF01923441. PMID   1582498. S2CID   21585912.
• Condon MR, Hall AK (1992). "Expression of thymosin beta-4 and related genes in developing human brain". J. Mol. Neurosci. 3 (3): 165–70. doi:10.1007/BF02919408. PMID   1627460. S2CID   11646975.
• Lin SC, Morrison-Bogorad M (1992). "Cloning and characterization of a testis-specific thymosin beta 10 cDNA. Expression in post-meiotic male germ cells". J. Biol. Chem. 266 (34): 23347–53. doi: 10.1016/S0021-9258(18)54503-8 . PMID   1744129.
• Hall AK (1991). "Differential expression of thymosin genes in human tumors and in the developing human kidney". Int. J. Cancer. 48 (5): 672–7. doi:10.1002/ijc.2910480507. PMID   2071228. S2CID   20642010.
• Hall AK, Hempstead J, Morgan JI (1990). "Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma". Brain Res. Mol. Brain Res. 8 (2): 129–35. doi:10.1016/0169-328X(90)90057-K. PMID   2169566.
• Weterman MA, van Muijen GN, Ruiter DJ, Bloemers HP (1993). "Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma". Int. J. Cancer. 53 (2): 278–84. doi:10.1002/ijc.2910530218. PMID   8425765. S2CID   45935594.
• Lapteva N, Ando Y, Nieda M, et al. (2001). "Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array". Br. J. Haematol. 114 (1): 191–7. doi: 10.1046/j.1365-2141.2001.02910.x . PMID   11472367. S2CID   29115214.
• Bani-Yaghoub M, Felker JM, Ozog MA, et al. (2002). "Array analysis of the genes regulated during neuronal differentiation of human embryonal cells". Biochem. Cell Biol. 79 (4): 387–98. doi:10.1139/bcb-79-4-387. PMID   11527208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Santelli G, Bartoli PC, Giuliano A, et al. (2003). "Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium". Thyroid. 12 (9): 765–72. doi:10.1089/105072502760339325. PMID   12481941.
• Johansson U, Olsson A, Gabrielsson S, et al. (2003). "Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation". Biochem. Biophys. Res. Commun. 308 (3): 474–9. doi:10.1016/S0006-291X(03)01392-5. PMID   12914774.
• Rho SB, Chun T, Lee SH, et al. (2004). "The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture". FEBS Lett. 557 (1–3): 57–63. doi: 10.1016/S0014-5793(03)01438-8 . PMID   14741341. S2CID   84342157.
• Chiappetta G, Pentimalli F, Monaco M, et al. (2005). "Thymosin beta-10 gene expression as a possible tool in diagnosis of thyroid neoplasias". Oncol. Rep. 12 (2): 239–43. doi:10.3892/or.12.2.239. PMID   15254683.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Lee SH, Son MJ, Oh SH, et al. (2005). "Thymosin {beta}(10) inhibits angiogenesis and tumor growth by interfering with Ras function". Cancer Res. 65 (1): 137–48. doi: 10.1158/0008-5472.137.65.1 . PMID   15665289. S2CID   10722553.
• Rho SB, Lee KW, Chun T, et al. (2005). "The identification of apoptosis-related residues in human thymosin beta-10 by mutational analysis and computational modeling". J. Biol. Chem. 280 (40): 34003–7. doi: 10.1074/jbc.M501629200 . PMID   16012174.
• Maelan AE, Rasmussen TK, Larsson LI (2007). "Localization of thymosin beta10 in breast cancer cells: relationship to actin cytoskeletal remodeling and cell motility". Histochem. Cell Biol. 127 (1): 109–13. doi:10.1007/s00418-006-0208-z. PMID   16786322. S2CID   37856926.
• Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–18. doi: 10.1016/j.molcel.2006.06.026 . PMID   16916647.