TMSB15A

TMSB15A
Identifiers
Aliases	TMSB15A , TMSB15, TMSB15B, TMSL8, TMSNB, Tb15, TbNB, thymosin beta 15a
External IDs	OMIM: 300939 GeneCards: TMSB15A
Gene location (Human)
Chr.	X chromosome (human)
End	102,516,739 bp
Gene ontology
Molecular function	• actin binding ; • actin monomer binding ; • molecular function ; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	• cytoskeleton ; • cytoplasm ; • cellular component ;
Biological process	• actin filament organization ; • regulation of cell migration ; • sequestering of actin monomers ; • positive regulation of cell migration ; • regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	11013
	n/a
	ENSG00000158164
	n/a
	P0CG34 ; P0CG35
	n/a
	NM_021992
	n/a
NP_001337140 ; NP_001337141 ; NP_001337142 ; NP_919305 ; NP_068832 ;
	NP_068832
	n/a
	Wikidata
View/Edit Human

Last updated September 22, 2021

Thymosin beta-15A is a protein that in humans is encoded by the TMSB15A gene.^[3]^[4]

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Thymosin beta-15B is a protein that, in humans, is encoded by the TMSB15B gene. The protein is identical in aminoacid sequence to Thymosin beta-15A, product of the TMSB15A gene, although synthesis of the two proteins is independently regulated.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000158164 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: thymosin beta 15a".
↑ Banyard J, Hutchinson LM, Zetter BR (September 2007). "Thymosin beta-NB is the human isoform of rat thymosin beta15". Ann. N. Y. Acad. Sci. 1112: 286–96. doi:10.1196/annals.1415.024. PMID 17567946. S2CID 41879096.

Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286 . PMID 15772651.
Yokoyama M, Nishi Y, Yoshii J, et al. (1996). "Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles". DNA Res. 3 (5): 311–20. doi: 10.1093/dnares/3.5.311 . PMID 9039501.
Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide Regimen". PLOS Med. 4 (3): e90. doi:10.1371/journal.pmed.0040090. PMC 1831731 . PMID 17388661.
Bao L, Loda M, Janmey PA, et al. (1996). "Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer". Nat. Med. 2 (12): 1322–8. doi:10.1038/nm1296-1322. PMID 8946830. S2CID 848538.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Dhaese S, Jonckheere V, Goethals M, et al. (2007). "Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin beta is the true human homologue of rat thymosin beta15". FEBS Lett. 581 (25): 4809–15. doi: 10.1016/j.febslet.2007.09.003 . PMID 17888914.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Banyard J, Barrows C, Zetter BR (2009). "Differential Regulation of Human Thymosin Beta 15 Isoforms by Transforming Growth Factor Beta 1". Genes Chromosomes Cancer. 48 (6): 502–9. doi:10.1002/gcc.20659. PMC 2756613 . PMID 19296525.
Gu YM, Li SY, Qiu XS, Wang EH (2008). "Elevated thymosin beta15 expression is associated with progression and metastasis of non-small cell lung cancer". APMIS. 116 (6): 484–90. doi:10.1111/j.1600-0463.2008.00918.x. PMID 18754322. S2CID 85038190.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000158164 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: thymosin beta 15a".

[pmid17567946-4] Banyard J, Hutchinson LM, Zetter BR (September 2007). "Thymosin beta-NB is the human isoform of rat thymosin beta15". Ann. N. Y. Acad. Sci. 1112: 286–96. doi:10.1196/annals.1415.024. PMID 17567946. S2CID 41879096.

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TMSB15A

Contents

See also

Related Research Articles

References

Further reading