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Leukotriene B4 receptor 2, also known as BLT2, BLT2 receptor, and BLTR2, is an Integral membrane protein that is encoded by the LTB4R2 gene in humans and the Ltbr2 gene in mice.
Diablo homolog (DIABLO) is a mitochondrial protein that in humans is encoded by the DIABLO gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis. Due to its proapoptotic function, SMAC is implicated in a broad spectrum of tumors, and small molecule SMAC mimetics have been developed to enhance current cancer treatments.
CD47 also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis.
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Deleted in Liver Cancer 1 also known as DLC1 and StAR-related lipid transfer protein 12 (STARD12) is a protein which in humans is encoded by the DLC1 gene.
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Serine/threonine-protein kinase PAK 5 is an enzyme that in humans is encoded by the PAK5 gene.
WNT1-inducible-signaling pathway protein 1 (WISP-1), also known as CCN4, is a matricellular protein that in humans is encoded by the WISP1 gene.
A metastasis suppressor is a protein that acts to slow or prevent metastases from spreading in the body of an organism with cancer. Metastasis is one of the most lethal cancer processes. This process is responsible for about ninety percent of human cancer deaths. Proteins that act to slow or prevent metastases are different from those that act to suppress tumor growth. Genes for about a dozen such proteins are known in humans and other animals.
PIN2/TERF1-interacting telomerase inhibitor 1, also known as PINX1, is a human gene. PINX1 is also known as PIN2 interacting protein 1. PINX1 is a telomerase inhibitor and a possible tumor suppressor.
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Cytoskeleton regulator RNA is a long non-coding RNA that in humans is encoded by the CYTOR gene.
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hPG80 refers to the extracellular and oncogenic version of progastrin. This name first appeared in a scientific publication in January 2020. Until that date, scientific publications only mention 'progastrin', without necessarily explicitly specifying whether it is intracellular or extracellular in the tumor pathological setting.
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References
- ↑ Pu, Chi; Ciren, Yangla; Liu, Yun; Long, Ziwen (2021-01-01). "TRIM52 knockdown inhibits cell proliferation and induces apoptosis through activation of the STAT3 pathway in ovarian cancer1". All Life. Informa UK Limited. 14 (1): 646–656. doi: 10.1080/26895293.2021.1947394 . ISSN 2689-5293. S2CID 237771422.
- ↑ Zheng, Beiyi; Wang, Jianhua; Wang, Haozhen; Wang, Wenling; Jin, Yude (2022-06-17). "TRIM52 promotes proliferation, invasion, and migration of gastric cancer cells by regulating Wnt/β-catenin pathway". Tropical Journal of Pharmaceutical Research. African Journals Online (AJOL). 21 (5): 957–963. doi: 10.4314/tjpr.v21i5.8 . ISSN 1596-9827. S2CID 249968002.
- ↑ Guo, Yanjiao; Zhou, Yiming; Gu, Xiaodong; Xiang, Jianbin (2022). "Tripartite motif 52 (TRIM52) promotes proliferation, migration, and regulation of colon cancer cells associated with the NF-κB signaling pathway". Journal of Gastrointestinal Oncology. AME Publishing Company. 13 (3): 1097–1111. doi: 10.21037/jgo-22-317 . ISSN 2078-6891. PMC 9274054 . PMID 35837156.
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