Tripartite motif family

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The tripartite motif family (TRIM) is a protein family. [1]

Contents

Function

Many TRIM proteins are induced by interferons, which are important component of resistance to pathogens and several TRIM proteins are known to be required for the restriction of infection by lentiviruses. TRIM proteins are involved in pathogen-recognition and by regulation of transcriptional pathways in host defence. [2]

Structure

The tripartite motif is always present at the N-terminus of the TRIM proteins. The TRIM motif includes the following three domains: [1]

The C-terminus of TRIM proteins contain either:

Family members

The TRIM family is split into two groups that differ in domain structure and genomic organization: [3]

Members of the family include:

Related Research Articles

TRIM5alpha

Tripartite motif-containing protein 5 also known as RING finger protein 88 is a protein that in humans is encoded by the TRIM5 gene. The alpha isoform of this protein, TRIM5α, is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection.

TRIM28

Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1, is a protein that in humans is encoded by the TRIM28 gene.

TRIM21

Tripartite motif-containing protein 21, also known as E3 ubiquitin-protein ligase TRIM21, is a protein that in humans is encoded by the TRIM21 gene. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. It is expressed in most human tissues.

MID1

MID1 is a protein that belongs to the Tripartite motif family (TRIM) and is also known as TRIM18. The MID1 gene is located on the short arm of the X chromosome and loss-of-function mutations in this gene are causative of the X-linked form of a rare developmental disease, Opitz G/BBB Syndrome.

TRIM24

Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.

TRIM27

Zinc finger protein RFP is a protein that in humans is encoded by the TRIM27 gene.

TRIM37

Tripartite motif-containing protein 37 is an E3 ubiquitin ligase in humans that is encoded by the TRIM37 gene.

TRIM25

Tripartite motif-containing protein 25 is a protein that in humans is encoded by the TRIM25 gene.

MID2

Midline-2 is a protein that in humans is encoded by the MID2 gene.

TRIM32

Tripartite motif-containing protein 32 is a protein that in humans is encoded by the TRIM32 gene. Since its discovery in 1995, TRIM32 has been shown to be implicated in a number of diverse biological pathways.

TRIM23

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.

TRIM22

Tripartite motif-containing 22, also known as TRIM22, is a protein which in humans is encoded by the TRIM22 gene.

TRIM31

Tripartite motif-containing protein 31 is a protein that in humans is encoded by the TRIM31 gene.

TRIM33

Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ), is a human gene.

TRIM3

Tripartite motif-containing protein 3 is a protein that in humans is encoded by the TRIM3 gene.

TRIM16

Tripartite motif-containing protein 16 is a protein that in humans is encoded by the TRIM16 gene.

TRIM9

Tripartite motif-containing protein 9 is a protein that in humans is encoded by the TRIM9 gene.

TRIM6

Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.

TRIM11

Tripartite motif-containing protein 11 is a protein found in humans that is encoded by the TRIM11 gene.

TRIM15

Tripartite motif-containing protein 15 is a protein that in humans is encoded by the TRIM15 gene.

References

  1. 1 2 Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC   125245 . PMID   11331580.
  2. Ozato K, Shin DM, Chang TH, Morse HC (November 2008). "TRIM family proteins and their emerging roles in innate immunity". Nat. Rev. Immunol. 8 (11): 849–60. doi:10.1038/nri2413. PMC   3433745 . PMID   18836477.
  3. Sardiello M, Cairo S, Fontanella B, Ballabio A, Meroni G (2008). "Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties". BMC Evol. Biol. 8: 225. doi:10.1186/1471-2148-8-225. PMC   2533329 . PMID   18673550.
  4. Ponting C, Schultz J, Bork P (June 1997). "SPRY domains in ryanodine receptors (Ca(2+)-release channels)". Trends Biochem. Sci. 22 (6): 193–4. doi:10.1016/S0968-0004(97)01049-9. PMID   9204703.