TRIM16

TRIM16
Identifiers
Aliases	TRIM16 , EBBP, tripartite motif containing 16
External IDs	OMIM: 609505; MGI: 2137356; HomoloGene: 4726; GeneCards: TRIM16; OMA:TRIM16 - orthologs
Gene location (Mouse) Chr. Chromosome 11 (mouse) [1] Band 11|11 B2 Start 62,711,057 bp [1] End 62,741,634 bp [1]
Gene ontology Molecular function DNA binding zinc ion binding interleukin-1 binding protein binding metal ion binding NACHT domain binding transferase activity Cellular component cytoplasm PML body intracellular anatomical structure cytosol plasma membrane Biological process histone H4 acetylation positive regulation of keratinocyte differentiation positive regulation of transcription, DNA-templated response to organophosphorus positive regulation of retinoic acid receptor signaling pathway response to retinoic acid histone H3 acetylation response to growth hormone Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10626 94092 Ensembl ENSG00000221926 ENSMUSG00000047821 UniProt O95361 Q99PP9 RefSeq (mRNA) NM_006470 NM_053169 RefSeq (protein) NP_006461 NP_001335049 NP_001335050 NP_001335051 NP_001335053 NP_001335054 NP_001335055 NP_001335048 NP_444399 Location (UCSC) n/a Chr 11: 62.71 – 62.74 Mb PubMed search [2] [3]
Wikidata
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Tripartite motif-containing protein 16 is a protein that in humans is encoded by the TRIM16 gene. ^{[4] [5]}

This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family.

The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined. ^[5]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000047821 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC   125245 . PMID   11331580.
5. "Entrez Gene: TRIM16 tripartite motif-containing 16".

Further reading

• Liu HL, Golder-Novoselsky E, Seto MH, et al. (1999). "The novel estrogen-responsive B-box protein (EBBP) gene is tamoxifen-regulated in cells expressing an estrogen receptor DNA-binding domain mutant". Mol. Endocrinol. 12 (11): 1733–48. doi: 10.1210/mend.12.11.0193 . PMID   9817599.
• Beer HD, Munding C, Dubois N, et al. (2002). "The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation". J. Biol. Chem. 277 (23): 20740–9. doi: 10.1074/jbc.M111233200 . hdl: 20.500.11850/91604 . PMID   11919186.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Munding C, Keller M, Niklaus G, et al. (2006). "The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion". Cell Death Differ. 13 (11): 1938–49. doi:10.1038/sj.cdd.4401896. PMID   16575408. S2CID   8953820.
• Cheung BB, Bell J, Raif A, et al. (2006). "The estrogen-responsive B box protein is a novel regulator of the retinoid signal". J. Biol. Chem. 281 (26): 18246–56. doi: 10.1074/jbc.M600879200 . PMID   16636064.