TRIM31

TRIM31
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YSJ, 2YSL
Identifiers
Aliases	TRIM31 , C6orf13, HCG1, HCGI, RNF, tripartite motif containing 31
External IDs	OMIM: 609316 MGI: 2385051 HomoloGene: 17137 GeneCards: TRIM31
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.1 Start 30,102,897 bp [1] End 30,113,090 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B1 Start 37,209,010 bp [2] End 37,221,106 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum duodenum appendix gallbladder urinary bladder body of stomach gastric mucosa smooth muscle tissue Right adrenal gland right uterine tube Top expressed in intestinal villus jejunum duodenum left colon ileum Paneth cell crypt of lieberkuhn of small intestine Hindgut morula secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding protein binding metal ion binding transferase activity Cellular component cytoplasm cytosol intracellular anatomical structure mitochondrion Biological process positive regulation of DNA-binding transcription factor activity protein ubiquitination interferon-gamma-mediated signaling pathway negative regulation of viral transcription innate immune response negative regulation of viral entry into host cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11074 224762 Ensembl ENSG00000223531 ENSG00000137397 ENSG00000233573 ENSG00000224168 ENSG00000225130 ENSG00000226402 ENSG00000224542 ENSG00000204616 ENSMUSG00000058063 UniProt Q9BZY9 Q2L6J1 Q8R0K2 RefSeq (mRNA) NM_007028 NM_146077 RefSeq (protein) NP_008959 NP_008959.3 NP_666189 Location (UCSC) Chr 6: 30.1 – 30.11 Mb Chr 17: 37.21 – 37.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tripartite motif-containing protein 31 is a protein that in humans is encoded by the TRIM31 gene. ^{[5] [6]}

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus. Its function has not been identified. ^[6]

Interactions

TRIM31 has been shown to interact with TRIM23. ^[5]

References

1. ENSG00000137397, ENSG00000233573, ENSG00000224168, ENSG00000225130, ENSG00000226402, ENSG00000224542, ENSG00000204616 GRCh38: Ensembl release 89: ENSG00000223531, ENSG00000137397, ENSG00000233573, ENSG00000224168, ENSG00000225130, ENSG00000226402, ENSG00000224542, ENSG00000204616 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058063 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC   125245 . PMID   11331580.
6. "Entrez Gene: TRIM31 tripartite motif-containing 31".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• el Kahloun A, Chauvel B, Mauvieux V, et al. (1993). "Localization of seven new genes around the HLA-A locus". Hum. Mol. Genet. 2 (1): 55–60. doi:10.1093/hmg/2.1.55. PMID   8490624.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC   395752 . PMID   14759258.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID   16341674. S2CID   69278.
• Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity". Genetics. 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC   1526686 . PMID   16702430.