TRIM23

Last updated

TRIM23
Identifiers
Aliases TRIM23 , ARD1, ARFD1, RNF46, tripartite motif containing 23
External IDs OMIM: 601747; MGI: 1933161; HomoloGene: 1251; GeneCards: TRIM23; OMA:TRIM23 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001656
NM_033227
NM_033228

NM_030731
NM_001361538
NM_001361539

RefSeq (protein)

NP_001647
NP_150230
NP_150231

NP_001348467
NP_001348468

Location (UCSC) Chr 5: 65.59 – 65.63 Mb Chr 13: 104.32 – 104.34 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene. [5] [6]

Contents

Function

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phospholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [6]

Interactions

TRIM23 has been shown to interact with TRIM31, [7] TRIM29 [7] and PSCD1. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000113595 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021712 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M (Apr 1993). "ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain". The Journal of Biological Chemistry. 268 (12): 8801–7. doi: 10.1016/S0021-9258(18)52945-8 . PMID   8473324.
  6. 1 2 "Entrez Gene: TRIM23 tripartite motif-containing 23".
  7. 1 2 Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". The EMBO Journal. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC   125245 . PMID   11331580.
  8. Vitale N, Pacheco-Rodriguez G, Ferrans VJ, Riemenschneider W, Moss J, Vaughan M (Jul 2000). "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)". The Journal of Biological Chemistry. 275 (28): 21331–9. doi: 10.1074/jbc.M909642199 . PMID   10748148.

Further reading