CRTC2

CRTC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HTM
Identifiers
Aliases	CRTC2 , TORC-2, TORC2, CREB regulated transcription coactivator 2
External IDs	OMIM: 608972; MGI: 1921593; HomoloGene: 18765; GeneCards: CRTC2; OMA:CRTC2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.3 Start 153,947,669 bp [1] End 153,958,615 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F1 Start 90,161,470 bp [2] End 90,171,432 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte left ovary right ovary right hemisphere of cerebellum right lung spleen right lobe of thyroid gland left lobe of thyroid gland canal of the cervix body of uterus Top expressed in neural layer of retina lumbar spinal ganglion tail of embryo genital tubercle granulocyte lip muscle of thigh cerebellar cortex thymus superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function chromatin binding protein binding cAMP response element binding protein binding Cellular component cytoplasm extracellular exosome nucleus nucleoplasm Biological process gluconeogenesis histone H3-K9 acetylation positive regulation of CREB transcription factor activity viral process regulation of transcription, DNA-templated protein homotetramerization toxin transport glucose homeostasis transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 200186 74343 Ensembl ENSG00000160741 ENSMUSG00000027936 UniProt Q53ET0 Q3U182 RefSeq (mRNA) NM_181715 NM_028881 NM_001357152 RefSeq (protein) NP_859066 NP_083157 NP_001344081 Location (UCSC) Chr 1: 153.95 – 153.96 Mb Chr 3: 90.16 – 90.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene. ^{[5] [6] [7]}

Function

CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP. ^[8] CRTC2 is thought to drive tumorigenesis in STK11(LKB1)-null non-small cell lung cancers (NSCLC). ^[9]

Interactions

CRTC2 has been shown to interact with SNF1LK2 ^[10] and YWHAQ. ^{[10] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000160741 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027936 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2".
6. Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi: 10.1073/pnas.1932773100 . PMC   218727 . PMID   14506290.
7. Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi: 10.1016/j.molcel.2003.08.013 . PMID   14536081.
8. Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". BioEssays. 28 (3): 231–4. CiteSeerX   10.1.1.604.5745 . doi:10.1002/bies.20375. PMID   16479585.
9. Rodón L, Svensson RU, Wiater E, Chun MG, Tsai WW, Eichner LJ, et al. (July 2019). "The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer". Science Advances. 5 (7) eaaw6455. Bibcode:2019SciA....5.6455R. doi:10.1126/sciadv.aaw6455. PMC   6656544 . PMID   31355336.
10. Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi: 10.1016/j.cell.2004.09.015 . PMID   15454081. S2CID   18616459.
11. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi: 10.1073/pnas.1932773100 . PMC   218727 . PMID   14506290.
• Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi: 10.1016/j.molcel.2003.08.013 . PMID   14536081.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, et al. (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi: 10.1016/j.cell.2004.09.015 . PMID   15454081. S2CID   18616459.
• Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, et al. (December 2005). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". Journal of Cell Science. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID   16306228. S2CID   17404931.
• Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY (July 2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats". Journal of Virology. 80 (14): 7052–9. doi:10.1128/JVI.00103-06. PMC   1489057 . PMID   16809310.
• Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, et al. (September 2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells". Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14379–84. Bibcode:2006PNAS..10314379W. doi: 10.1073/pnas.0606714103 . PMC   1569674 . PMID   16980408.
• Yang Q, Inoki K, Ikenoue T, Guan KL (October 2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes & Development. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMC   1619946 . PMID   17043309.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M (June 2007). "Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression". The EMBO Journal. 26 (12): 2880–9. doi:10.1038/sj.emboj.7601715. PMC   1894761 . PMID   17476304.
• Kuraishy AI, French SW, Sherman M, Herling M, Jones D, Wall R, Teitell MA (June 2007). "TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation". Proceedings of the National Academy of Sciences of the United States of America. 104 (24): 10175–80. Bibcode:2007PNAS..10410175K. doi: 10.1073/pnas.0704170104 . PMC   1891214 . PMID   17548807.

External links

• CRTC2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CRTC2 genome location and CRTC2 gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : Q53ET0 (Human CREB-regulated transcription coactivator 2) at the PDBe-KB .
• Overview of all the structural information available in the PDB for UniProt : Q3U182 (Mouse CREB-regulated transcription coactivator 2) at the PDBe-KB .