YWHAQ

YWHAQ
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2BTP, 5IQP
Identifiers
Aliases	YWHAQ , 14-3-3, 1C5, HS1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
External IDs	OMIM: 609009 MGI: 3650241 HomoloGene: 105677 GeneCards: YWHAQ
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p25.1 Start 9,583,967 bp [1] End 9,630,997 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm endothelial cell pons superior vestibular nucleus parotid gland inferior ganglion of vagus nerve secondary oocyte hair follicle human penis tibia n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane transporter binding protein domain specific binding protein N-terminus binding 14-3-3 protein binding protein C-terminus binding protein binding identical protein binding Cellular component cytoplasm cytosol membrane focal adhesion extracellular exosome cytoplasmic vesicle membrane mitochondrion protein-containing complex synapse Biological process protein targeting substantia nigra development negative regulation of ion transmembrane transport positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway membrane organization negative regulation of transcription, DNA-templated small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10971 102634437 Ensembl ENSG00000134308 n/a UniProt P27348 n/a RefSeq (mRNA) NM_006826 n/a RefSeq (protein) NP_006817 n/a Location (UCSC) Chr 2: 9.58 – 9.63 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

14-3-3 protein theta is a protein that in humans is encoded by the YWHAQ gene. ^[4]

Function

This gene product belongs to the 14-3-3 family of proteins that mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence that is polymorphic; however, there is no correlation between the repeat number and the disease. ^[5]

Interactions

YWHAQ has been shown to interact with:

• BAX, ^[6]
• BAD, ^{[7] [8]}
• C-Raf, ^{[9] [10] [11] [12]}
• CRTC2, ^{[13] [9]}
• CBL ^{[12] [14]}
• HDAC5, ^[15]
• MEF2D, ^[16]
• NRIP1, ^[17]
• PFKFB2, ^[18]
• PRKD1, ^{[19] [20]}
• PRKCZ, ^[11]
• TERT, ^[21] and
• UCP3. ^[22]

References

1. GRCh38: Ensembl release 89: ENSG00000134308 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Malaspina A, Kaushik N, de Belleroche J (November 2000). "A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord". J Neurochem. 75 (6): 2511–20. doi: 10.1046/j.1471-4159.2000.0752511.x . PMID   11080204. S2CID   2941793.
5. "Entrez Gene: YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide".
6. Nomura M, Shimizu S, Sugiyama T, Narita M, Ito T, Matsuda H, Tsujimoto Y (January 2003). "14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax". J. Biol. Chem. 278 (3): 2058–65. doi: 10.1074/jbc.M207880200 . PMID   12426317.
7. Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell. 17 (3): 393–403. doi: 10.1016/j.molcel.2004.12.030 . PMID   15694340.
8. Hsu SY, Kaipia A, Zhu L, Hsueh AJ (November 1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11". Mol. Endocrinol. 11 (12): 1858–67. doi: 10.1210/mend.11.12.0023 . PMID   9369453.
9. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
10. Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, Kolch W (May 2000). "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein". Mol. Cell. Biol. 20 (9): 3079–85. doi:10.1128/MCB.20.9.3079-3085.2000. PMC   85596 . PMID   10757792.
11. Van Der Hoeven PC, Van Der Wal JC, Ruurs P, Van Dijk MC, Van Blitterswijk J (January 2000). "14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation". Biochem. J. 345 (2): 297–306. doi:10.1042/0264-6021:3450297. PMC   1220759 . PMID   10620507.
12. Liu YC, Elly C, Yoshida H, Bonnefoy-Berard N, Altman A (June 1996). "Activation-modulated association of 14-3-3 proteins with Cbl in T cells". J. Biol. Chem. 271 (24): 14591–5. doi: 10.1074/jbc.271.24.14591 . PMID   8663231.
13. Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi: 10.1016/j.cell.2004.09.015 . PMID   15454081. S2CID   18616459.
14. Pedraza-Alva G, Sawasdikosol S, Liu YC, Mérida LB, Cruz-Muñoz ME, Oceguera-Yañez F, Burakoff SJ, Rosenstein Y (January 2001). "Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells". J. Biol. Chem. 276 (1): 729–37. doi: 10.1074/jbc.M008494200 . PMID   11024037.
15. Vega RB, Harrison BC, Meadows E, Roberts CR, Papst PJ, Olson EN, McKinsey TA (October 2004). "Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5". Mol. Cell. Biol. 24 (19): 8374–85. doi:10.1128/MCB.24.19.8374-8385.2004. PMC   516754 . PMID   15367659.
16. Choi SJ, Park SY, Han TH (July 2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation". Nucleic Acids Res. 29 (13): 2836–42. doi:10.1093/nar/29.13.2836. PMC   55772 . PMID   11433030.
17. Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA (April 2001). "Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140". Mol. Endocrinol. 15 (4): 501–11. doi: 10.1210/mend.15.4.0624 . PMID   11266503.
18. Pozuelo Rubio M, Peggie M, Wong BH, Morrice N, MacKintosh C (July 2003). "14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase". EMBO J. 22 (14): 3514–23. doi:10.1093/emboj/cdg363. PMC   165633 . PMID   12853467.
19. Storz P, Hausser A, Link G, Dedio J, Ghebrehiwet B, Pfizenmaier K, Johannes FJ (August 2000). "Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32". J. Biol. Chem. 275 (32): 24601–7. doi: 10.1074/jbc.M002964200 . PMID   10831594.
20. Hausser A, Storz P, Link G, Stoll H, Liu YC, Altman A, Pfizenmaier K, Johannes FJ (April 1999). "Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins". J. Biol. Chem. 274 (14): 9258–64. doi: 10.1074/jbc.274.14.9258 . PMID   10092600.
21. Seimiya H, Sawada H, Muramatsu Y, Shimizu M, Ohko K, Yamane K, Tsuruo T (June 2000). "Involvement of 14-3-3 proteins in nuclear localization of telomerase". EMBO J. 19 (11): 2652–61. doi:10.1093/emboj/19.11.2652. PMC   212742 . PMID   10835362.
22. Pierrat B, Ito M, Hinz W, Simonen M, Erdmann D, Chiesi M, Heim J (May 2000). "Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family". Eur. J. Biochem. 267 (9): 2680–7. doi:10.1046/j.1432-1327.2000.01285.x. PMID   10785390.

Further reading

• Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024 (1): 153–67. Bibcode:2004NYASA1024..153K. doi:10.1196/annals.1321.013. PMID   15265780. S2CID   23655886.
• Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P (2006). "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium". Front. Biosci. 11: 1646–66. doi: 10.2741/1911 . PMID   16368544. S2CID   26325962.
• Nielsen PJ (1991). "Primary structure of a human protein kinase regulator protein". Biochim. Biophys. Acta. 1088 (3): 425–8. doi:10.1016/0167-4781(91)90136-a. PMID   2015305.
• Bonnefoy-Bérard N, Liu YC, von Willebrand M, Sung A, Elly C, Mustelin T, Yoshida H, Ishizaka K, Altman A (1995). "Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10142–6. Bibcode:1995PNAS...9210142B. doi: 10.1073/pnas.92.22.10142 . PMC   40752 . PMID   7479742.
• Xiao B, Smerdon SJ, Jones DH, Dodson GG, Soneji Y, Aitken A, Gamblin SJ (1995). "Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways". Nature. 376 (6536): 188–91. Bibcode:1995Natur.376..188X. doi:10.1038/376188a0. PMID   7603573. S2CID   4311234.
• Leffers H, Madsen P, Rasmussen HH, Honoré B, Andersen AH, Walbum E, Vandekerckhove J, Celis JE (1993). "Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway". J. Mol. Biol. 231 (4): 982–98. doi:10.1006/jmbi.1993.1346. PMID   8515476.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Liu YC, Elly C, Yoshida H, Bonnefoy-Berard N, Altman A (1996). "Activation-modulated association of 14-3-3 proteins with Cbl in T cells". J. Biol. Chem. 271 (24): 14591–5. doi: 10.1074/jbc.271.24.14591 . PMID   8663231.
• Papin C, Denouel A, Calothy G, Eychène A (1996). "Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system". Oncogene. 12 (10): 2213–21. PMID   8668348.
• Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ (1997). "Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)". Cell. 87 (4): 619–28. doi: 10.1016/S0092-8674(00)81382-3 . PMID   8929531. S2CID   860908.
• Suzuki Y, Demoliere C, Kitamura D, Takeshita H, Deuschle U, Watanabe T (1997). "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases". J. Immunol. 158 (6): 2736–44. doi: 10.4049/jimmunol.158.6.2736 . PMID   9058808. S2CID   25584050.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Dubois T, Rommel C, Howell S, Steinhussen U, Soneji Y, Morrice N, Moelling K, Aitken A (1997). "14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction". J. Biol. Chem. 272 (46): 28882–8. doi: 10.1074/jbc.272.46.28882 . PMID   9360956.
• Hsu SY, Kaipia A, Zhu L, Hsueh AJ (1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11". Mol. Endocrinol. 11 (12): 1858–67. doi: 10.1210/mend.11.12.0023 . PMID   9369453.
• Brunati AM, Donella-Deana A, James P, Quadroni M, Contri A, Marin O, Pinna LA (1999). "Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase". J. Biol. Chem. 274 (11): 7557–64. doi: 10.1074/jbc.274.11.7557 . PMID   10066823.
• Hausser A, Storz P, Link G, Stoll H, Liu YC, Altman A, Pfizenmaier K, Johannes FJ (1999). "Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins". J. Biol. Chem. 274 (14): 9258–64. doi: 10.1074/jbc.274.14.9258 . PMID   10092600.
• Finlin BS, Andres DA (1999). "Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins". Arch. Biochem. Biophys. 368 (2): 401–12. doi:10.1006/abbi.1999.1316. PMID   10441394.
• Chow CW, Davis RJ (2000). "Integration of calcium and cyclic AMP signaling pathways by 14-3-3". Mol. Cell. Biol. 20 (2): 702–12. doi:10.1128/MCB.20.2.702-712.2000. PMC   85175 . PMID   10611249.
• Mori H, Inoue M, Yano M, Wakabayashi H, Kido H (2000). "14-3-3tau associates with a translational control factor FKBP12-rapamycin-associated protein in T-cells after stimulation by pervanadate". FEBS Lett. 467 (1): 61–4. doi: 10.1016/S0014-5793(00)01126-1 . PMID   10664457. S2CID   12119302.
• Mils V, Baldin V, Goubin F, Pinta I, Papin C, Waye M, Eychene A, Ducommun B (2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257–65. doi: 10.1038/sj.onc.1203419 . PMID   10713667.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.