CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene. [5] [6] [7] [8] It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands [9] and various regions of the adult central nervous system. [10]
Production of CRTC1 is blocked in Alzheimer's disease. [11]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.