PNRC2

PNRC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B6H
Identifiers
Aliases	PNRC2 , proline rich nuclear receptor coactivator 2
External IDs	OMIM: 611882 MGI: 106512 HomoloGene: 9821 GeneCards: PNRC2
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.11 Start 23,956,839 bp [1] End 23,963,462 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 D3|4 68.01 cM Start 135,598,229 bp [2] End 135,601,161 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium parietal pleura cancellous bone visceral pleura lactiferous duct lower lobe of lung mucosa of urinary bladder renal medulla metanephric glomerulus superficial temporal artery Top expressed in parotid gland external carotid artery seminal vesicula medial ganglionic eminence internal carotid artery pituitary gland molar atrium Paneth cell cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component P-body nucleus cytoplasm nucleoplasm Golgi apparatus cytosol Biological process regulation of transcription, DNA-templated deadenylation-independent decapping of nuclear-transcribed mRNA transcription, DNA-templated nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55629 52830 Ensembl ENSG00000189266 ENSMUSG00000028675 UniProt Q9NPJ4 Q9CR73 RefSeq (mRNA) NM_017761 NM_026383 RefSeq (protein) NP_060231 NP_080659 Location (UCSC) Chr 1: 23.96 – 23.96 Mb Chr 4: 135.6 – 135.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proline-rich nuclear receptor coactivator 2 is a protein that in humans is encoded by the PNRC2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000189266 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028675 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhou D, Chen S (Sep 2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif". Nucleic Acids Res. 29 (19): 3939–48. doi:10.1093/nar/29.19.3939. PMC   60244 . PMID   11574675.
6. "Entrez Gene: PNRC2 proline-rich nuclear receptor coactivator 2".

Further reading

• Zhou D, Quach KM, Yang C, et al. (2000). "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986–98. doi: 10.1210/mend.14.7.0480 . PMID   10894149.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hentschke M, Borgmeyer U (2004). "Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma". Biochem. Biophys. Res. Commun. 312 (4): 975–82. doi:10.1016/j.bbrc.2003.11.025. PMID   14651967.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.

External links

• PNRC2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C185
• Overview of all the structural information available in the PDB for UniProt : Q9NPJ4 (Human Proline-rich nuclear receptor coactivator 2) at the PDBe-KB .