TGFB1I1

TGFB1I1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KLA, 1KLC, 1KLD, 3KFD, 4KV5
Identifiers
Aliases	TGFB1I1 , ARA55, HIC-5, HIC5, TSC-5, transforming growth factor beta 1 induced transcript 1
External IDs	OMIM: 602353; MGI: 102784; HomoloGene: 7572; GeneCards: TGFB1I1; OMA:TGFB1I1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p11.2 Start 31,471,585 bp [1] End 31,477,960 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F3 Start 127,845,984 bp [2] End 127,854,871 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein body of uterus myometrium popliteal artery tibial arteries left uterine tube thoracic aorta right coronary artery ascending aorta tail of epididymis Top expressed in ascending aorta tunica media of zone of aorta atrium external carotid artery internal carotid artery calvaria aortic valve lumbar spinal ganglion umbilical cord cervix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function I-SMAD binding transcription coactivator activity metal ion binding protein binding androgen receptor binding Roundabout binding transcription coregulator activity Cellular component cytoplasm focal adhesion nuclear matrix extracellular matrix intracellular anatomical structure cell junction cytoskeleton nucleus collagen-containing extracellular matrix cytosol plasma membrane Biological process androgen receptor signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway cell differentiation response to heat negative regulation of transforming growth factor beta receptor signaling pathway Wnt signaling pathway transcription by RNA polymerase II positive regulation of epithelial to mesenchymal transition ubiquitin-dependent SMAD protein catabolic process positive regulation of transcription, DNA-templated cell adhesion negative regulation of cell population proliferation morphogenesis of embryonic epithelium epithelial cell differentiation cell fate commitment negative regulation of fat cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7041 21804 Ensembl ENSG00000140682 ENSMUSG00000030782 UniProt O43294 Q62219 RefSeq (mRNA) NM_015927 NM_001042454 NM_001164719 NM_001289550 NM_001289551 NM_001289552 NM_001289553 NM_009365 RefSeq (protein) NP_001035919 NP_001158191 NP_057011 NP_001158191.1 NP_057011.2 NP_001276479 NP_001276480 NP_001276481 NP_001276482 Location (UCSC) Chr 16: 31.47 – 31.48 Mb Chr 7: 127.85 – 127.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transforming growth factor beta-1-induced transcript 1 protein is a protein that in humans is encoded by the TGFB1I1 gene. ^{[5] [6]} TGFB1I1 is also sometimes called HIC-5 (Hydrogen Peroxide-Inducible Clone-5) ^[7] or ARA55 (Androgen Receptor Coactivator 55kDA). ^[8]

As it's multiple names suggests, TGFB1I1 a protein whose expression is induced by TGFB1 and is both inducible by hydrogen peroxide, and a coactivator of the androgen receptors.

TGFB1I1 plays a role in processes of cell growth, proliferation, ^[9] migration, differentiation, ^[10] and senescence ^[11] in multiple contexts including in cancer. TGFB1I1 is most localized at focal adhesion complexes of cells, ^[5] although it may be found active in the cytosol, nucleus and cell membrane as well. ^{[9] [12] [13]}

Functions

Transforming growth factor beta-1-induced transcript 1 plays a role in a number of cell functions. Originally, TGFB1I1 was isolated as a senescence-inducing gene from mouse osteoblastic cells through treatment with transforming growth factor beta-1 and hydrogen peroxide. ^[11] During this, TGFB1I1 was also being independently discovered by numerous other groups and was characterized as a focal adhesion protein, ^{[14] [15]} an androgen and glucocorticoid receptor co-activator, ^{[12] [16]} a negative regulator of muscle differentiation, ^[10] and major player in the recovery of arterial media. ^{[17] [18]}

Interactions

TGFB1I1 has been shown to interact with:

• Androgen receptor, ^{[19] [20]}
• Dopamine transporter ^[21]
• Hsp27, ^[22]
• PTK2B, ^{[5] [19] [23]}
• PTK2, ^{[5] [23] [24]} and
• PTPN12. ^[25]

See also

• Transcription coregulator

References

1. GRCh38: Ensembl release 89: ENSG00000140682 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030782 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matsuya M, Sasaki H, Aoto H, Mitaka T, Nagura K, Ohba T, et al. (January 1998). "Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions". The Journal of Biological Chemistry. 273 (2): 1003–1014. doi: 10.1074/jbc.273.2.1003 . PMID   9422762.
6. Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A, Chang C (March 1999). "Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate". The Journal of Biological Chemistry. 274 (12): 8316–8321. doi: 10.1074/jbc.274.12.8316 . PMID   10075738.
7. Du X, Xu Q, Pan D, Xu D, Niu B, Hong W, Zhang R, Li X, Chen S (2019-11-18). "HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression". Cell Death & Disease. 10 (12): 873. doi:10.1038/s41419-019-2114-z. ISSN   2041-4889.
8. Cui Z, Chen Y (2020-03-04). "ARA55 in Cancers: A Double-Edged Sword". Biomedical Journal of Scientific & Technical Research. 26 (2): 19807–19811. doi:10.26717/BJSTR.2020.26.004326. ISSN   2574-1241.
9. Heitzer MD, DeFranco DB (July 2006). "Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells". Cancer Research. 66 (14): 7326–7333. doi:10.1158/0008-5472.can-05-2379. PMID   16849583.
10. Hu Y, Cascone PJ, Cheng L, Sun D, Nambu JR, Schwartz LM (August 1999). "Lepidopteran DALP, and its mammalian ortholog HIC-5, function as negative regulators of muscle differentiation". Proceedings of the National Academy of Sciences of the United States of America. 96 (18): 10218–10223. Bibcode:1999PNAS...9610218H. doi: 10.1073/pnas.96.18.10218 . PMC   17869 . PMID   10468589.
11. Shibanuma M, Mashimo J, Kuroki T, Nose K (October 1994). "Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence". The Journal of Biological Chemistry. 269 (43): 26767–26774. doi: 10.1016/S0021-9258(18)47085-8 . PMID   7929412.
12. Yang L, Guerrero J, Hong H, DeFranco DB, Stallcup MR (June 2000). "Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix". Molecular Biology of the Cell. 11 (6): 2007–2018. doi:10.1091/mbc.11.6.2007. PMC   14899 . PMID   10848625.
13. Shibanuma M, Kim-Kaneyama JR, Ishino K, Sakamoto N, Hishiki T, Yamaguchi K, et al. (March 2003). "Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal". Molecular Biology of the Cell. 14 (3): 1158–1171. doi:10.1091/mbc.02-06-0099. PMC   151587 . PMID   12631731.
14. Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (April 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain". The Journal of Biological Chemistry. 274 (14): 9847–9853. doi: 10.1074/jbc.274.14.9847 . PMID   10092676.
15. Thomas SM, Hagel M, Turner CE (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin". Journal of Cell Science. 112 ( Pt 2) (2): 181–190. doi:10.1242/jcs.112.2.181. PMID   9858471.
16. Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A, Chang C (March 1999). "Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate". The Journal of Biological Chemistry. 274 (12): 8316–8321. doi: 10.1074/jbc.274.12.8316 . PMID   10075738.
17. Ohanian J, Pieri M, Ohanian V (September 2015). "Non-receptor tyrosine kinases and the actin cytoskeleton in contractile vascular smooth muscle". The Journal of Physiology. 593 (17): 3807–3814. doi:10.1113/jphysiol.2014.284174. PMC   4575570 . PMID   25433074.
18. Kim-Kaneyama JR, Lei XF, Arita S, Miyauchi A, Miyazaki T, Miyazaki A (2012). "Hydrogen peroxide-inducible clone 5 (Hic-5) as a potential therapeutic target for vascular and other disorders". Journal of Atherosclerosis and Thrombosis. 19 (7): 601–607. doi: 10.5551/jat.10736 . PMID   22472216.
19. Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, et al. (May 2002). "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator". The Journal of Biological Chemistry. 277 (18): 15426–15431. doi: 10.1074/jbc.M111218200 . PMID   11856738.
20. He B, Minges JT, Lee LW, Wilson EM (March 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". The Journal of Biological Chemistry. 277 (12): 10226–10235. doi: 10.1074/jbc.M111975200 . PMID   11779876.
21. Carneiro AM, Ingram SL, Beaulieu JM, Sweeney A, Amara SG, Thomas SM, et al. (August 2002). "The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter". The Journal of Neuroscience. 22 (16): 7045–7054. doi: 10.1523/JNEUROSCI.22-16-07045.2002 . PMC   6757888 . PMID   12177201.
22. Jia Y, Ransom RF, Shibanuma M, Liu C, Welsh MJ, Smoyer WE (October 2001). "Identification and characterization of hic-5/ARA55 as an hsp27 binding protein". The Journal of Biological Chemistry. 276 (43): 39911–39918. doi: 10.1074/jbc.M103510200 . PMID   11546764.
23. Thomas SM, Hagel M, Turner CE (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin". Journal of Cell Science. 112 ( Pt 2) (2): 181–190. doi:10.1242/jcs.112.2.181. PMID   9858471.
24. Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K (August 2001). "Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase". Molecular and Cellular Biology. 21 (16): 5332–5345. doi:10.1128/MCB.21.16.5332-5345.2001. PMC   87257 . PMID   11463817.
25. Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (April 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain". The Journal of Biological Chemistry. 274 (14): 9847–9853. doi: 10.1074/jbc.274.14.9847 . PMID   10092676.

Further reading

• Yeh S, Sampson ER, Lee DK, Kim E, Hsu CL, Chen YL, et al. (December 2000). "Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer". Journal of the Formosan Medical Association = Taiwan Yi Zhi. 99 (12): 885–894. PMID   11155740.
• Heitzer MD, DeFranco DB (February 2007). "Hic-5/ARA55: a prostate stroma-specific AR coactivator". Steroids. 72 (2): 218–220. doi:10.1016/j.steroids.2006.11.010. PMID   17166536. S2CID   38796305.
• Wilson SE, Lloyd SA (September 1991). "Epidermal growth factor and its receptor, basic fibroblast growth factor, transforming growth factor beta-1, and interleukin-1 alpha messenger RNA production in human corneal endothelial cells". Investigative Ophthalmology & Visual Science. 32 (10): 2747–2756. PMID   1716619.
• Shibanuma M, Mashimo J, Kuroki T, Nose K (October 1994). "Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence". The Journal of Biological Chemistry. 269 (43): 26767–26774. doi: 10.1016/S0021-9258(18)47085-8 . PMID   7929412.
• Shibanuma M, Mochizuki E, Maniwa R, Mashimo J, Nishiya N, Imai S, et al. (March 1997). "Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts". Molecular and Cellular Biology. 17 (3): 1224–1235. doi:10.1128/mcb.17.3.1224. PMC   231847 . PMID   9032249.
• Fujita H, Kamiguchi K, Cho D, Shibanuma M, Morimoto C, Tachibana K (October 1998). "Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase". The Journal of Biological Chemistry. 273 (41): 26516–26521. doi: 10.1074/jbc.273.41.26516 . PMID   9756887.
• Thomas SM, Hagel M, Turner CE (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin". Journal of Cell Science. 112 ( Pt 2) (2): 181–190. doi:10.1242/jcs.112.2.181. PMID   9858471.
• Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (April 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain". The Journal of Biological Chemistry. 274 (14): 9847–9853. doi: 10.1074/jbc.274.14.9847 . PMID   10092676.
• Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, et al. (May 1999). "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling". The Journal of Cell Biology. 145 (4): 851–863. doi:10.1083/jcb.145.4.851. PMC   2133183 . PMID   10330411.
• Liu S, Thomas SM, Woodside DG, Rose DM, Kiosses WB, Pfaff M, Ginsberg MH (December 1999). "Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses". Nature. 402 (6762): 676–681. Bibcode:1999Natur.402..676L. doi:10.1038/45264. PMID   10604475. S2CID   2770368.
• Yang L, Guerrero J, Hong H, DeFranco DB, Stallcup MR (June 2000). "Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix". Molecular Biology of the Cell. 11 (6): 2007–2018. doi:10.1091/mbc.11.6.2007. PMC   14899 . PMID   10848625.
• Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, et al. (May 2001). "CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk". Blood. 97 (9): 2633–2639. doi: 10.1182/blood.V97.9.2633 . PMID   11313252.
• Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K (August 2001). "Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase". Molecular and Cellular Biology. 21 (16): 5332–5345. doi:10.1128/MCB.21.16.5332-5345.2001. PMC   87257 . PMID   11463817.
• Jia Y, Ransom RF, Shibanuma M, Liu C, Welsh MJ, Smoyer WE (October 2001). "Identification and characterization of hic-5/ARA55 as an hsp27 binding protein". The Journal of Biological Chemistry. 276 (43): 39911–39918. doi: 10.1074/jbc.M103510200 . PMID   11546764.
• Ting HJ, Yeh S, Nishimura K, Chang C (January 2002). "Supervillin associates with androgen receptor and modulates its transcriptional activity". Proceedings of the National Academy of Sciences of the United States of America. 99 (2): 661–666. Bibcode:2002PNAS...99..661T. doi: 10.1073/pnas.022469899 . PMC   117362 . PMID   11792840.
• Denhez F, Wilcox-Adelman SA, Baciu PC, Saoncella S, Lee S, French B, et al. (April 2002). "Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5". The Journal of Biological Chemistry. 277 (14): 12270–12274. doi: 10.1074/jbc.M110291200 . PMID   11805099.
• Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, et al. (May 2002). "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator". The Journal of Biological Chemistry. 277 (18): 15426–15431. doi: 10.1074/jbc.M111218200 . PMID   11856738.

External links

• TGFB1I1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C148

This article incorporates text from the United States National Library of Medicine, which is in the public domain.